Zobrazeno 1 - 10
of 51
pro vyhledávání: '"William R, English"'
Autor:
Caitlin E. Jackson, Iona Doyle, Hamood Khan, Samuel F. Williams, Betül Aldemir Dikici, Edgar Barajas Ledesma, Helen E. Bryant, William R. English, Nicola H. Green, Frederik Claeyssens
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2024)
Tumour survival and growth are reliant on angiogenesis, the formation of new blood vessels, to facilitate nutrient and waste exchange and, importantly, provide a route for metastasis from a primary to a secondary site. Whilst current models can ensur
Externí odkaz:
https://doaj.org/article/6e434095490c4230bbdd3443b1e0c64b
Autor:
Caitlin E. Jackson, David H. Ramos-Rodriguez, Nicholas T. H. Farr, William R. English, Nicola H. Green, Frederik Claeyssens
Publikováno v:
Bioengineering, Vol 10, Iss 5, p 522 (2023)
Cancer is a becoming a huge social and economic burden on society, becoming one of the most significant barriers to life expectancy in the 21st century. In particular, breast cancer is one of the leading causes of death for women. One of the most sig
Externí odkaz:
https://doaj.org/article/0738d8dc3bd34cea8be93a01ab64b812
Autor:
Thomas GP Grünewald, Marta Alonso, Sofia Avnet, Ana Banito, Stefan Burdach, Florencia Cidre‐Aranaz, Gemma Di Pompo, Martin Distel, Heathcliff Dorado‐Garcia, Javier Garcia‐Castro, Laura González‐González, Agamemnon E Grigoriadis, Merve Kasan, Christian Koelsche, Manuela Krumbholz, Fernando Lecanda, Silvia Lemma, Dario L Longo, Claudia Madrigal‐Esquivel, Álvaro Morales‐Molina, Julian Musa, Shunya Ohmura, Benjamin Ory, Miguel Pereira‐Silva, Francesca Perut, Rene Rodriguez, Carolin Seeling, Nada Al Shaaili, Shabnam Shaabani, Kristina Shiavone, Snehadri Sinha, Eleni M Tomazou, Marcel Trautmann, Maria Vela, Yvonne MH Versleijen‐Jonkers, Julia Visgauss, Marta Zalacain, Sebastian J Schober, Andrej Lissat, William R English, Nicola Baldini, Dominique Heymann
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 11, Pp 1-33 (2020)
Abstract Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and compr
Externí odkaz:
https://doaj.org/article/32421af97ff64f339c73c8bfd6f57409
Autor:
Gillian M. Tozer, Chryso Kanthou, Scott K. Lyons, Jack E. Hurrell, Karina Bingham, Yu-Chin Lee, Mohit Dhingra, Diane V. Lefley, Matthew Fisher, Sarah Jane Lunt, William R. English
Elevated plasma concentrations of soluble VEGFA isoforms are associated with poor prognosis in parallel with improved response to treatment with the anti-VEGFA antibody bevacizumab. To uncover the underlying mechanism to these observations, we admini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aaba787cfa8fbaa921a7be20ca3fdb1
https://doi.org/10.1158/0008-5472.c.6508532.v1
https://doi.org/10.1158/0008-5472.c.6508532.v1
Autor:
Gillian M. Tozer, Chryso Kanthou, Scott K. Lyons, Jack E. Hurrell, Karina Bingham, Yu-Chin Lee, Mohit Dhingra, Diane V. Lefley, Matthew Fisher, Sarah Jane Lunt, William R. English
The supplementary methods file contains additional detailed information regarding: 1. The production of cell lines stably expressing luciferase. 2. Mouse strains and pre-clinical models of tumor growth and metastasis. 3. Acquisition and analysis of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709da946d9d38146143bb30503defe37
https://doi.org/10.1158/0008-5472.22412831
https://doi.org/10.1158/0008-5472.22412831
Autor:
Gillian M. Tozer, Chryso Kanthou, Scott K. Lyons, Jack E. Hurrell, Karina Bingham, Yu-Chin Lee, Mohit Dhingra, Diane V. Lefley, Matthew Fisher, Sarah Jane Lunt, William R. English
The supplementary data file contains the following data and figures: Fig S1- CD31 and CD34 co-localize to the vasculature in fs120-LS and fs188-LS subcutaneous tumors. Fig S2 - VEGFR1 activity has no effect on tumor growth or vascular density of subc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879f1996c9bcc2c06fc8c711e0cc0f3f
https://doi.org/10.1158/0008-5472.22412834.v1
https://doi.org/10.1158/0008-5472.22412834.v1
Autor:
William R English, Heather Ireland-Zecchini, Andrew H Baker, Trevor D Littlewood, Martin R Bennett, Gillian Murphy
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195116 (2018)
Over expression of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in vascular smooth muscle cells (VSMCs) induces apoptosis and reduces neointima formation occurring after saphenous vein interposition grafting or coronary stenting. In studies to a
Externí odkaz:
https://doaj.org/article/b9a6a700721b4c0887a29d0b18bb7cb1
Publikováno v:
Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism
Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism, Elsevier, 2020, 31 (6), pp.398-409. ⟨10.1016/j.tem.2020.01.014⟩
Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism, Elsevier, 2020, 31 (6), pp.398-409. ⟨10.1016/j.tem.2020.01.014⟩
In this opinion article we critically assess evidence for the existence of a family of antiangiogenic vascular endothelial growth factor (Vegfaxxxb) transcripts, arising from the use of a phylogenetically conserved alternative distal splice site with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead2db3bb8c3ea363ad8da4198804062
https://doi.org/10.1016/j.tem.2020.01.014
https://doi.org/10.1016/j.tem.2020.01.014
Autor:
Chryso Kanthou, Gabi U Dachs, Diane V Lefley, Andrew J Steele, Claudia Coralli-Foxon, Sheila Harris, Olga Greco, Sofia A Dos Santos, Constantino C Reyes-Aldasoro, William R English, Gillian M Tozer
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104015 (2014)
Vascular endothelial growth factor-A (VEGF) is produced by most cancer cells as multiple isoforms, which display distinct biological activities. VEGF plays an undisputed role in tumour growth, vascularisation and metastasis; nevertheless the function
Externí odkaz:
https://doaj.org/article/2f15655a60294b4ea0c0503622288433
Autor:
Milly West, Stewart Cleeve, Charles H. Knowles, William R. English, Sara Peroos, Vinayata Sheshappanavar, Joanne E. Martin, John V Kendall
Publikováno v:
Journal of clinical pathology.
AimsMegarectum is well described in the surgical literature but few contemporary pathological studies have been undertaken. There is uncertainty whether ‘idiopathic’ megarectum is a primary neuromuscular disorder or whether chronic dilatation lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e871413aa35bde5fccf2e0e39af3ae4
https://pubmed.ncbi.nlm.nih.gov/34035078
https://pubmed.ncbi.nlm.nih.gov/34035078