Zobrazeno 1 - 10
of 16
pro vyhledávání: '"William Planer"'
Publikováno v:
Frontiers in Medicine, Vol 5 (2018)
Coagulation factor II, or prothrombin, is a multi-domain glycoprotein that is essential for life and a key target of anticoagulant therapy. In plasma, prothrombin circulates in two forms at equilibrium, “closed” (~80%) and “open” (~20%), brok
Externí odkaz:
https://doaj.org/article/0b1233a64e0147df9c8bda4b14c95077
Autor:
Suresh, Kumar, Mathivanan, Chinnaraj, William, Planer, Xiaobing, Zuo, Paolo, Macor, Francesco, Tedesco, Nicola, Pozzi
Publikováno v:
The Journal of Biological Chemistry
β2-glycoprotein I (β2GPI) is an abundant multidomain plasma protein that plays various roles in the clotting and complement cascades. It is also the main target of antiphospholipid antibodies (aPL) in the acquired coagulopathy known as antiphosphol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6aada29bd0a0621ec2df2435cf183f97
https://pubmed.ncbi.nlm.nih.gov/34197876
https://pubmed.ncbi.nlm.nih.gov/34197876
Autor:
Claudia Grossi, Pier Luigi Meroni, William Planer, Fleur Bossi, Peter Garred, Paolo Durigutto, Nicola Pozzi, Francesco Tedesco, Maria Orietta Borghi, Paolo Macor, Chiara Agostinis
Publikováno v:
J Immunol
β2-Glycoprotein I (β2-GPI) is an abundant plasma glycoprotein with unknown physiological function and is currently recognized as the main target of antiphospholipid Abs responsible for complement activation and vascular thrombosis in patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a9b4002525d5843a73dba7bb10ba09
https://pubmed.ncbi.nlm.nih.gov/32759297
https://pubmed.ncbi.nlm.nih.gov/32759297
Autor:
Paolo Macor, Vittorio Pengo, Ravi Kumar Alluri, Nicola Pozzi, Mathivanan Chinnaraj, Eliza A. Ruben, Keith R. McCrae, William Planer, Vincenzo De Filippis, Francesco Tedesco, Xiaobing Zuo, Zhiwei Chen
Venous and arterial thromboses in patients suffering from the autoimmune disorder Antiphospholipid Syndrome (APS) are caused by the presence of antiphospholipid antibodies (aPL). Emerging evidence indicates that autoantibodies targeting the epitope R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3b0c8f5c95e1b61ddd5c14122f8c07
https://doi.org/10.1101/2020.02.25.963314
https://doi.org/10.1101/2020.02.25.963314
Autor:
Mathivanan Chinnaraj, Zhiwei Chen, Francesco Tedesco, Vittorio Pengo, Eliza A. Ruben, William Planer, Vincenzo De Filippis, Xiaobing Zuo, Nicola Pozzi, Paolo Macor, Ravi Kumar Alluri, Keith R. McCrae
Publikováno v:
J Biol Chem
β(2)-Glycoprotein I (β(2)GPI) is an abundant plasma protein displaying phospholipid-binding properties. Because it binds phospholipids, it is a target of antiphospholipid antibodies (aPLs) in antiphospholipid syndrome (APS), a life-threatening auto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5b2919cdacd56ef196bdcf2e6bae5a
https://hdl.handle.net/11368/2992297
https://hdl.handle.net/11368/2992297
Autor:
Paolo Macor, Suresh Kumar, Francesco Tedesco, Nicola Pozzi, Mathivanan Chinnaraj, William Planer, Xiaobing Zuo
Publikováno v:
Journal of Biological Chemistry. 297:100890
β2-glycoprotein I (β2GPI) is an abundant multi-domain plasma protein that plays various roles in the clotting and complement cascades. It is also the main target of antiphospholipid antibodies (aPL) in the acquired coagulopathy known as Antiphospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70bd2ed1d4baf5504b480b5605705db
https://doi.org/10.1016/j.jbc.2021.100890
https://doi.org/10.1016/j.jbc.2021.100890
Anti-phosphatidylserine/prothrombin (aPS/PT) antibodies are often detected in patients with antiphospholipid syndrome (APS), but how aPS/PT engage prothrombin at the molecular level remains unknown. Here, the antigenic determinants of immunoglobulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d96ec3a496aae7d6163d060eb02e0d
https://europepmc.org/articles/PMC6560356/
https://europepmc.org/articles/PMC6560356/
Autor:
Durga P. Mohapatra, Ronald A. Merrill, Stefan Strack, Suraj Kadunganattil, William Planer, Raeesa Gupte, Michael R. Bruchas, Andrew J. Shepherd
Publikováno v:
Neuropharmacology. 101:291-308
The endogenous neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is secreted by both neuronal and non-neuronal cells in the brain and spinal cord, in response to pathological conditions such as stroke, seizures, chronic inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d1e793145941cb81f4fd21036a8753
https://doi.org/10.1016/j.neuropharm.2015.10.006
https://doi.org/10.1016/j.neuropharm.2015.10.006
Autor:
Xiaobing Zuo, Zhiwei Chen, Nicola Pozzi, Mathivanan Chinnaraj, Vittorio Pengo, Paolo Macor, Francesco Tedesco, William Planer
Publikováno v:
Blood. 134:91-91
Background. Antiphospholipid antibodies (aPL) recognizing an epitope comprising residues R39-R43 in the N-terminal domain, Domain I (DI), of beta-2 glycoprotein I (b2GPI) are considered among the most pathogenic in patients with Antiphospholipid Synd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7a6fb09f87524ba1f06fcc41d0256c3
https://doi.org/10.1182/blood-2019-122064
https://doi.org/10.1182/blood-2019-122064
Autor:
Lucy Stickler, Steven D. Chang, Edward R. Siuda, Yu-Qing Cao, William Planer, Michael R. Bruchas, Hu-Chen Zhao, Nan Zhang, Madison A. Baird
Publikováno v:
Journal of Biological Chemistry. 287:42019-42030
We determined the role of carboxyl-terminal regulation of NOPR (nociceptin, orphanin FQ receptor) signaling and function. We mutated C-terminal serine and threonine residues and examined their role in NOPR trafficking, homologous desensitization, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd16de0ce8eaf6fad419ad4de29106a7
https://doi.org/10.1074/jbc.m112.405696
https://doi.org/10.1074/jbc.m112.405696