Zobrazeno 1 - 10
of 17
pro vyhledávání: '"William Pat Fong"'
Autor:
Zi-Jing Li, William Pat Fong, Dong-Sheng Zhang, Hui-Yan Luo, Dong-Liang Chen, Yan-Yu Cai, Zhi-Gang Chen, Jian-Li Duan, Zi-Yao Huang, Yu-Ting Lu, Xiao-Xia Huang, Yu-Hong Li, De-Shen Wang
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-6 (2024)
Abstract Anaplastic lymphoma kinase (ALK) fusion-positive colorectal cancer (CRC) is a rare and chemotherapy-refractory subtype that lacks established and effective treatment strategies. Additionally, the efficacy and safety of ALK inhibitors (ALKi)
Externí odkaz:
https://doaj.org/article/bbdc714779f84f3980277043828d8a35
Autor:
De-Shen Wang, Chao Ren, Shan-Shan Li, William Pat Fong, Xiao-Jun Wu, Jian Xiao, Bin-Kui Li, Yun Zheng, Pei-Rong Ding, Gong Chen, Miao-Zhen Qiu, Zhi-Qiang Wang, Feng-Hua Wang, Hui-Yan Luo, Feng Wang, Xiao-Zhong Wang, Ling-Yun Wang, De-Jin Xie, Tao Chen, Li-Ren Li, Zhen-Hai Lu, Xiao-Hui Zhai, Tian-Shu Liu, Ying Yuan, Jia-Qi Chen, Qiong Tan, Zhi-Zhong Pan, De-Sen Wan, Rong Zhang, Yun-Fei Yuan, Rui-Hua Xu, Yu-Hong Li
Publikováno v:
PLoS Medicine, Vol 21, Iss 5, p e1004389 (2024)
BackgroundIt remains unclear whether intensification of the chemotherapy backbone in tandem with an anti-EGFR can confer superior clinical outcomes in a cohort of RAS/BRAF wild-type colorectal cancer (CRC) patients with initially unresectable colorec
Externí odkaz:
https://doaj.org/article/b9e6a45661f549378ef2d8ab851edf5e
Autor:
Zhi-Gang Chen, Xiao-Meng Ji, Yu-Xia Xu, William Pat Fong, Xiao-Yun Liu, Jie-Ying Liang, Qiong Tan, Lei Wen, Yan-Yu Cai, De-Shen Wang, Yu-Hong Li
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background: Patients with initially unresectable colorectal cancer liver metastases (IU-CRLM) might benefit from using an effective systemic treatment followed by resection of liver metastases but the curative success rate is quite low. Indeed, nearl
Externí odkaz:
https://doaj.org/article/ccaf6294ee4a4f3d94a0190ab3a31533
Autor:
Zi-Yao Huang, Lei Wen, Liu-Fang Ye, Yu-Ting Lu, William Pat Fong, Ren-Jing Zhang, Si-Xian Wu, Zhi-Gang Chen, Yan-Yu Cai, Rui-Hua Xu, Yu-Hong Li, Zi-Ming Du, De-Shen Wang
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background: Transmembrane E3 ubiquitin ligase ( RNF43 ) mutations are present in approximately 6–18% of colorectal cancers (CRC) and could enhance Wnt/β-catenin signaling, which is emerging as a promising therapeutic target. This study aims to inv
Externí odkaz:
https://doaj.org/article/d267fbf1f23c40f6a8146f578616f919
Autor:
Mingtao Hu, Zhigang Chen, Dandan Hu, Shaoyan Xi, Deshen Wang, Xiaolong Zhang, William Pat Fong, Lei Wen, Yanyu Cai, Yunfei Yuan, Binkui Li, Xiaojun Wu, Zhenhai Lu, Gong Chen, Liren Li, Peirong Ding, Zhizhong Pan, Desen Wan, Ziming Du, Minshan Chen, Yuhong Li
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundHistopathological growth patterns (HGPs) have shown important prognostic values for patients with colorectal cancer liver metastases, but the potential molecular mechanisms remain largely unknown.MethodsWe performed an exploratory analysis
Externí odkaz:
https://doaj.org/article/22c653656a674d9e86a26c300b12b81b
Autor:
Chao Ren, Zhigang Chen, Yuhong Li, Lei Wen, Xiaomeng Ji, William Pat Fong, Qiong Shao, Yanyu Cai, Binkui Li, Yunfei Yuan, Deshen Wang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Patients with polymerase epsilon (POLE) exonuclease domain mutation (EDM) exhibits distinct clinical characteristics and extremely high tumor mutation burden (TMB). There is a paucity of data on the therapeutic efficacy of immune checkpoint inhibitor
Externí odkaz:
https://doaj.org/article/83a5bac81ff745bca1bea02755d86058
Autor:
Yun Wang, Xiuxing Chen, Haocheng Lin, Xiaoqiang Sun, William Pat Fong, Xiaojun Wu, Zhizhong Pan, Yunfei Yuan, Jieying Liang, Deshen Wang, Ziming Du, Baocai Xing, Yuhong Li
Publikováno v:
Cancers, Vol 13, Iss 17, p 4258 (2021)
Background: The clinical risk score (CRS) for prediction and treatment decision in colorectal liver metastasis (CRLM) is important, but imprecise. Exosomal miRNAs play critical roles in CRLM-related biological behavior. However, an exosomal miRNA sco
Externí odkaz:
https://doaj.org/article/37e73ebc482f4a78af94ece63a04fa62
Autor:
Lei, Wen, Zhigang, Chen, Xiaomeng, Ji, William Pat, Fong, Qiong, Shao, Chao, Ren, Yanyu, Cai, Binkui, Li, Yunfei, Yuan, Deshen, Wang, Yuhong, Li
Publikováno v:
Journal for immunotherapy of cancer. 10(7)
Patients with polymerase epsilon (
Autor:
Ye Zhao, Rui Zhou, Kunyu Yang, Tao Zhang, William Pat Fong, Xiaorong Dong, Xiaohua Jie, Yingchao Zhao, Gang Wu, Shuangbing Xu, Sheng Zhang, Rui Meng
Publikováno v:
Cell Death and Differentiation
Radioresistance is regarded as the main barrier to effective radiotherapy in lung cancer. However, the underlying mechanisms of radioresistance remain elusive. Here, we show that lysine-specific demethylase 4C (KDM4C) is overexpressed and correlated
Autor:
Hui Yang, Yuan-Chao Zheng, Xiao-Yun Liu, De Shen Wang, William Pat Fong, Yun Zheng, Zhizhong Pan, Rui-Hua Xu, Yunfei Yuan, Yun Wang, Zhi-gang Chen, Lele Song, Yu Hong Li, Binkui Li, Gong Chen, Ming-Tao Hu
Publikováno v:
Theranostics
Rationale: Hepatectomy and adjuvant chemotherapy after resection of colorectal liver metastases (CRLM) may improve survival, however, patients which may benefit cannot currently be identified. Postoperative circulating tumor DNA (ctDNA) analysis can