Zobrazeno 1 - 10
of 114
pro vyhledávání: '"William P.J. Leenders"'
Longitudinal analysis on the ecological dynamics of the cervicovaginal microbiome in hrHPV infection
Autor:
Mariano A. Molina, Willem J.G. Melchers, Karolina M. Andralojc, William P.J. Leenders, Martijn A. Huynen
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4424-4431 (2023)
The cervicovaginal microbiome (CVM) is a dynamic continuous microenvironment that can be clustered in microbial community state types (CSTs) and is associated with women’s cervical health. Lactobacillus-depleted communities particularly associate w
Externí odkaz:
https://doaj.org/article/d35db961d3b5445790e72f357751bb34
Autor:
Nik Sol, Sjors G.J.G. in ‘t Veld, Adrienne Vancura, Maud Tjerkstra, Cyra Leurs, François Rustenburg, Pepijn Schellen, Heleen Verschueren, Edward Post, Kenn Zwaan, Jip Ramaker, Laurine E. Wedekind, Jihane Tannous, Bauke Ylstra, Joep Killestein, Farrah Mateen, Sander Idema, Philip C. de Witt Hamer, Anna C. Navis, William P.J. Leenders, Ann Hoeben, Bastiaan Moraal, David P. Noske, W. Peter Vandertop, R. Jonas A. Nilsson, Bakhos A. Tannous, Pieter Wesseling, Jaap C. Reijneveld, Myron G. Best, Thomas Wurdinger
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 7, Pp 100101- (2020)
Summary: Tumor-educated platelets (TEPs) are potential biomarkers for cancer diagnostics. We employ TEP-derived RNA panels, determined by swarm intelligence, to detect and monitor glioblastoma. We assessed specificity by comparing the spliced RNA pro
Externí odkaz:
https://doaj.org/article/3c63ceb85e20460e8535824c45ce6bd6
Autor:
Jeannette C. Oosterwijk-Wakka, Mirjam C.A. de Weijert, Gerben M. Franssen, William P.J. Leenders, Jeroen A.W.M. van der Laak, Otto C. Boerman, Peter F.A. Mulders, Egbert Oosterwijk
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 2, Pp 215-224 (2015)
Anti-angiogenic treatment with tyrosine kinase inhibitors (TKI) has lead to an impressive increase in progression-free survival for patients with metastatic RCC (mRCC), but mRCC remains largely incurable. We combined sunitinib, targeting the endothel
Externí odkaz:
https://doaj.org/article/8f0c10faebec477d816eb5096e6a1c06
Publikováno v:
Cancers
Volume 13
Issue 5
Cancers, Vol 13, Iss 1069, p 1069 (2021)
Cancers, 13
Cancers, 13, 5
Volume 13
Issue 5
Cancers, Vol 13, Iss 1069, p 1069 (2021)
Cancers, 13
Cancers, 13, 5
Simple Summary Cell lines are widely used for research, but even commonly used cell lines may not be well characterized, making validation of published data and generalizing the results to the clinic problematic. Here, we have established a head and
Autor:
Elba Marin, Laura López-Vilaró, Santiago Viteri, Sonia Rodríguez, Ana Giménez-Capitán, Ivana Sullivan, Sergi Castillo, Miguel Mesa-Guzman, Noemí Reguart, Rafael Rosell, Ruth Román, Elena Gonzalvo, Silvia Muñoz, Nuria Viñolas, Aleix Prat, Luis M. Montuenga, Cristina Aguado, Maria Gonzalez-Cao, Cristina Teixido, Irene Moya, María Dolores Lozano, Carlos Cabrera, Andrés Felipe Cardona, Ramon Palmero, Roxana Reyes, Miguel Angel Molina-Vila, Erika Aldeguer, Alejandro Martinez-Bueno, Cristina Sainz, Ainara Arcocha, William P.J. Leenders, A. Aguilar-Hernández
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5015f96f9f62f89d44507e87d3eb2b42
https://doi.org/10.1002/1878-0261.12861/v2/response1
https://doi.org/10.1002/1878-0261.12861/v2/response1
Autor:
François Rustenburg, Cyra E. Leurs, Bakhos A. Tannous, Maud Tjerkstra, Farrah J. Mateen, Sander Idema, Bauke Ylstra, W. Peter Vandertop, Laurine E. Wedekind, Nik Sol, Adrienne Vancura, Edward Post, William P.J. Leenders, R. Jonas A. Nilsson, B. Moraal, Jip Ramaker, Anna C. Navis, Kenn Zwaan, Ann Hoeben, Sjors G J G In 't Veld, Jihane Tannous, Joep Killestein, Philip C. De Witt Hamer, Jaap C. Reijneveld, Thomas Wurdinger, Heleen Verschueren, Pieter Wesseling, Pepijn Schellen, David P. Noske, Myron G. Best
Publikováno v:
Cell Reports Medicine, 1(7):100101. Cell Press
Cell reports. Medicine, 1(7):100101. Cell Press
Cell Reports Medicine, Vol 1, Iss 7, Pp 100101-(2020)
Cell Reports Medicine, 1, 7
Cell Reports. Medicine
Cell Reports Medicine, 1
Sol, N, in ‘t Veld, S G J G, Vancura, A, Tjerkstra, M, Leurs, C, Rustenburg, F, Schellen, P, Verschueren, H, Post, E, Zwaan, K, Ramaker, J, Wedekind, L E, Tannous, J, Ylstra, B, Killestein, J, Mateen, F, Idema, S, de Witt Hamer, P C, Navis, A C, Leenders, W P J, Hoeben, A, Moraal, B, Noske, D P, Vandertop, W P, Nilsson, R J A, Tannous, B A, Wesseling, P, Reijneveld, J C, Best, M G & Wurdinger, T 2020, ' Tumor-Educated Platelet RNA for the Detection and (Pseudo)progression Monitoring of Glioblastoma ', Cell reports. Medicine, vol. 1, no. 7, 100101, pp. 100101 . https://doi.org/10.1016/j.xcrm.2020.100101, https://doi.org/10.1016/j.xcrm.2020.100101
Cell reports. Medicine, 1(7):100101. Cell Press
Cell Reports Medicine, Vol 1, Iss 7, Pp 100101-(2020)
Cell Reports Medicine, 1, 7
Cell Reports. Medicine
Cell Reports Medicine, 1
Sol, N, in ‘t Veld, S G J G, Vancura, A, Tjerkstra, M, Leurs, C, Rustenburg, F, Schellen, P, Verschueren, H, Post, E, Zwaan, K, Ramaker, J, Wedekind, L E, Tannous, J, Ylstra, B, Killestein, J, Mateen, F, Idema, S, de Witt Hamer, P C, Navis, A C, Leenders, W P J, Hoeben, A, Moraal, B, Noske, D P, Vandertop, W P, Nilsson, R J A, Tannous, B A, Wesseling, P, Reijneveld, J C, Best, M G & Wurdinger, T 2020, ' Tumor-Educated Platelet RNA for the Detection and (Pseudo)progression Monitoring of Glioblastoma ', Cell reports. Medicine, vol. 1, no. 7, 100101, pp. 100101 . https://doi.org/10.1016/j.xcrm.2020.100101, https://doi.org/10.1016/j.xcrm.2020.100101
Summary Tumor-educated platelets (TEPs) are potential biomarkers for cancer diagnostics. We employ TEP-derived RNA panels, determined by swarm intelligence, to detect and monitor glioblastoma. We assessed specificity by comparing the spliced RNA prof
Autor:
William P.J. Leenders, Inge Ebisch, Valentina Palacio-Castañeda, Jelske M de Jong, Wouter P. R. Verdurmen, Dirk van den Brand, Mark A.J. Gorris, Mark R G Goldman, Leon F.A.G. Massuger, Sanne A. M. van Lith, Roland Brock, Stijn T Couwenbergh
Publikováno v:
Cancers, Vol 12, Iss 1762, p 1762 (2020)
Cancers
Volume 12
Issue 7
Cancers, 12
Cancers, 12, 7
Cancers
Volume 12
Issue 7
Cancers, 12
Cancers, 12, 7
Ovarian cancer is the most lethal gynecological malignancy due to late detection associated with dissemination throughout the abdominal cavity. Targeted photodynamic therapy (tPDT) aimed at epithelial cell adhesion molecule (EpCAM), overexpressed in
Autor:
Silvia Muñoz, William P.J. Leenders, A. Aguilar-Hernández, Luis M. Montuenga, Roxana Reyes, Maria Gonzalez-Cao, R. Roman, Elena Gonzalvo, Cristina Sainz, Cristina Teixidó, Andrés F. Cardona, Maria D. Lozano, Elba Marin, Ainara Arcocha, Carlos R. Cabrera, Miguel Mesa-Guzman, Aleix Prat, Miguel Angel Molina-Vila, I. Sullivan, Cristina Aguado, Alejandro Martinez-Bueno, Erika Aldeguer, Irene Moya, Ramon Palmero, Noemi Reguart, Rafael Rosell, Laura López-Vilaró, Ana Giménez-Capitán, Santiago Viteri, Sonia Rodríguez, Sergi Castillo, Nuria Viñolas
Publikováno v:
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Molecular Oncology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Fundacion Sancho el Sabio Fundazioa (FSS)
Molecular Oncology, Vol 15, Iss 2, Pp 350-363 (2021)
Molecular Oncology, 15, 350-363
Scientia
Molecular Oncology, 15, 2, pp. 350-363
Universitat Autònoma de Barcelona
Molecular Oncology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Fundacion Sancho el Sabio Fundazioa (FSS)
Molecular Oncology, Vol 15, Iss 2, Pp 350-363 (2021)
Molecular Oncology, 15, 350-363
Scientia
Molecular Oncology, 15, 2, pp. 350-363
We studied MET alterations in 474 advanced non‐small‐cell lung cancer (NSCLC) patients by nCounter, an RNA‐based technique. We identified 3% with METΔex14 mRNA and 3.5% with very‐high MET mRNA expression, a surrogate of MET amplification. ME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c00b42c81cc41a7f2eb1ec563f3b10
https://ddd.uab.cat/record/238801
https://ddd.uab.cat/record/238801
Autor:
Pirjo Laakkonen, Joni Merisaari, Milena Doroszko, David Kastrinsky, Oxana V. Denisova, William P.J. Leenders, Goutham Narla, Michael Ohlmeyer, Nilesh Zaware, Vadim Le Joncour, Patrik Johansson, Jukka Westermarck, Sven Nelander
Publikováno v:
Brain Communications, 2
Brain Communications
Brain Communications, 2, 1
Brain Communications
Brain Communications, 2, 1
Glioblastoma is a fatal disease in which most targeted therapies have clinically failed. However, pharmacological reactivation of tumour suppressors has not been thoroughly studied as yet as a glioblastoma therapeutic strategy. Tumour suppressor prot
Autor:
Ruud L.M. Bekkers, Corina N. A. M. van den Heuvel, Johan Bulten, Albert G. Siebers, Diede L. Loopik, Karolina M. Andralojc, Duaa Elmelik, Martijn A. Huynen, Willem J. G. Melchers, Leon F.A.G. Massuger, William P.J. Leenders, Renée M.F. Ebisch
Publikováno v:
Modern Pathology, 33, 748-757
Modern Pathology, 33, 4, pp. 748-757
Modern Pathology, 33, 4, pp. 748-757
Contains fulltext : 218234.pdf (Publisher’s version ) (Closed access) Nearly all cervical cancers are initiated by a persistent infection with one of the high-risk human papillomaviruses (high-risk HPV). High-risk HPV DNA testing is highly sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6d72537b649d8362fa9b3c3483d349
http://hdl.handle.net/2066/218234
http://hdl.handle.net/2066/218234