Zobrazeno 1 - 10
of 90
pro vyhledávání: '"William P.D. Hendricks"'
Autor:
Jessica D. Lang, Tuong Vi V. Nguyen, Maren K. Levin, Page E. Blas, Heather L. Williams, Esther San Roman Rodriguez, Natalia Briones, Claudius Mueller, William Selleck, Sarah Moore, Victoria L. Zismann, William P.D. Hendricks, Virginia Espina, Joyce O’Shaughnessy
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-23 (2023)
Abstract Background A subset of triple-negative breast cancers (TNBCs) have homologous recombination deficiency with upregulation of compensatory DNA repair pathways. PIKTOR, a combination of TAK-228 (TORC1/2 inhibitor) and TAK-117 (PI3Kα inhibitor)
Externí odkaz:
https://doaj.org/article/52d8e016d5974151b746534d27914afc
Autor:
David G. Huntsman, Bernard E. Weissman, Jeffrey M. Trent, Gregg B. Morin, T. Michael Underhill, Ralf Hass, Anthony N. Karnezis, Marcel B. Bally, William P.D. Hendricks, Jessica D. Lang, Krystal A. Orlando, Nancy Dos Santos, Chae Young Shin, Galen Lambert, Shane Colborne, Shary Yuting Chen, Yemin Wang
Fig.S1 shows that SCCOHT cells are sensitive to HDAC inhibition. Fig. S2 shows that SCCOHT cells are sensitive to HDAC inhibition or depletion. Fig.S3 shows that SMARCA4/A2 dual deficiency is not associated with hypersensitivity to HDAC inhibitors in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2396ee9de14b76e5d7859ed9f267bb73
https://doi.org/10.1158/1535-7163.22510063.v1
https://doi.org/10.1158/1535-7163.22510063.v1
Autor:
David G. Huntsman, Bernard E. Weissman, Jeffrey M. Trent, Gregg B. Morin, T. Michael Underhill, Ralf Hass, Anthony N. Karnezis, Marcel B. Bally, William P.D. Hendricks, Jessica D. Lang, Krystal A. Orlando, Nancy Dos Santos, Chae Young Shin, Galen Lambert, Shane Colborne, Shary Yuting Chen, Yemin Wang
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but extremely lethal malignancy that mainly impacts young women. SCCOHT is characterized by a diploid genome with loss of SMARCA4 and lack of SMARCA2 expression, two mutually ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37952b52d6236e3e9efd5a279b26f72e
https://doi.org/10.1158/1535-7163.c.6539491
https://doi.org/10.1158/1535-7163.c.6539491
Autor:
David G. Huntsman, Bernard E. Weissman, Jeffrey M. Trent, Gregg B. Morin, T. Michael Underhill, Ralf Hass, Anthony N. Karnezis, Marcel B. Bally, William P.D. Hendricks, Jessica D. Lang, Krystal A. Orlando, Nancy Dos Santos, Chae Young Shin, Galen Lambert, Shane Colborne, Shary Yuting Chen, Yemin Wang
Table S1 shows the cell viability inhibitory rate (%) in SCCOHT cell lines vs other cell lines in the epigenetic drug screen. Table S2 shows the effects of Quisinostat on the proteome of BIN67 cells after treatment for 24 or 72 hours. Table S3 shows
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43304537c45779fc06e18054f0e3bb95
https://doi.org/10.1158/1535-7163.22510060.v1
https://doi.org/10.1158/1535-7163.22510060.v1
Autor:
William P.D. Hendricks, David P. Carbone, Jeffrey M. Trent, Muhammed Murtaza, Timothy G. Whitsett, Krista La Perle, Michael J. Koenig, Sara L. Sinicropi-Yao, Joseph M. Amann, Winnie S. Liang, Kevin Drenner, Shukmei Wong, Salvatore Facista, Alexandra Nazareno, Tania Contente-Cuomo, Nieves Perdigones, Victoria Zismann, Karthigayini Sivaprakasam, Gwendolen Lorch
HER2 cellular location and function in primary canine lung cancer. (A) Canine papillary adenocarcinoma with intense, complete, circumferential membrane (white arrow) and lateral cytoplasmic membrane (black arrow) anti-HER2 antibody positive staining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1417b8f796ed605bad3a5ccdc4e3067
https://doi.org/10.1158/1078-0432.22474629.v1
https://doi.org/10.1158/1078-0432.22474629.v1
Autor:
Jeffrey M. Trent, David G. Huntsman, Bernard E. Weissman, Praveen Nair, Barbara C. Vanderhyden, Ralf Hass, Aleksandar Sekulic, Anthony N. Karnezis, Yemin Wang, Michael B. Major, Emily M. Cousins, Victoria L. Zismann, Salvatore J. Facista, Megan Washington, Winnie S. Liang, Nanyun Tang, Chris Sereduk, Elizabeth A. Raupach, Patrick Pirrotte, Ritin Sharma, Pilar Ramos, Jeffrey Kiefer, Hongwei Yin, Krystal A. Orlando, William P.D. Hendricks, Jessica D. Lang
IC50 summary of validated drug hits in SCCOHT cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38616ea70cb460eabed4bb61f65d7345
https://doi.org/10.1158/1078-0432.22464359.v1
https://doi.org/10.1158/1078-0432.22464359.v1
Autor:
Jeffrey M. Trent, Giselle L. Saulnier Sholler, Javed Khan, Rebecca F. Halperin, Jonathan J. Keats, Szabolcs Szelinger, Bryce Turner, Austin Christofferson, Faith Cisneros, Apurva M. Hegde, Daniel Enriquez, Tyler Izatt, Sara Nasser, Alison Roos, Hue V. Reardon, Xinyu Wen, Jun S. Wei, Hsien-Chao Chou, Jeffrey Bond, Karl Dykema, Elizabeth VanSickle, Genevieve Bergendahl, Virginia L. Harrod, Peter E. Zage, Kathleen Neville, Jawhar Rawwas, Randal K. Wada, Javier E. Oesterheld, Michael S. Isakoff, William Roberts, Albert Cornelius, Deanna Mitchell, Don E. Eslin, Valerie I. Brown, William S. Ferguson, Jacqueline M. Kraveka, Abhinav B. Nagulapally, William P.D. Hendricks, Sara A. Byron
Additional Longitudinal Analysis of Relapsed and Refractory Childhood Solid Tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358f5743a8a96e060a39f9e37a70c1e5
https://doi.org/10.1158/0008-5472.22431250.v1
https://doi.org/10.1158/0008-5472.22431250.v1
Autor:
William P.D. Hendricks, David P. Carbone, Jeffrey M. Trent, Muhammed Murtaza, Timothy G. Whitsett, Krista La Perle, Michael J. Koenig, Sara L. Sinicropi-Yao, Joseph M. Amann, Winnie S. Liang, Kevin Drenner, Shukmei Wong, Salvatore Facista, Alexandra Nazareno, Tania Contente-Cuomo, Nieves Perdigones, Victoria Zismann, Karthigayini Sivaprakasam, Gwendolen Lorch
Supplementary Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54eebc4d8dacbd5615201bb5cc5aa83c
https://doi.org/10.1158/1078-0432.22474617.v1
https://doi.org/10.1158/1078-0432.22474617.v1
Autor:
Jeffrey M. Trent, Giselle L. Saulnier Sholler, Javed Khan, Rebecca F. Halperin, Jonathan J. Keats, Szabolcs Szelinger, Bryce Turner, Austin Christofferson, Faith Cisneros, Apurva M. Hegde, Daniel Enriquez, Tyler Izatt, Sara Nasser, Alison Roos, Hue V. Reardon, Xinyu Wen, Jun S. Wei, Hsien-Chao Chou, Jeffrey Bond, Karl Dykema, Elizabeth VanSickle, Genevieve Bergendahl, Virginia L. Harrod, Peter E. Zage, Kathleen Neville, Jawhar Rawwas, Randal K. Wada, Javier E. Oesterheld, Michael S. Isakoff, William Roberts, Albert Cornelius, Deanna Mitchell, Don E. Eslin, Valerie I. Brown, William S. Ferguson, Jacqueline M. Kraveka, Abhinav B. Nagulapally, William P.D. Hendricks, Sara A. Byron
Table S1. Extended Cohort Annotations. Table S2. Mutational Signatures. Table S3. GISTIC Copy Number Analysis. Table S4. Somatic Variants in Relapsed/Refractory Childhood Solid Tumors (n=184 Patients with T/N WES). Table S5. Clinvar Pathogenic and Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e39ae7fd69f2b814d3c10f93f7f3e1
https://doi.org/10.1158/0008-5472.22431247.v1
https://doi.org/10.1158/0008-5472.22431247.v1
Autor:
Jeffrey M. Trent, David G. Huntsman, Bernard E. Weissman, Praveen Nair, Barbara C. Vanderhyden, Ralf Hass, Aleksandar Sekulic, Anthony N. Karnezis, Yemin Wang, Michael B. Major, Emily M. Cousins, Victoria L. Zismann, Salvatore J. Facista, Megan Washington, Winnie S. Liang, Nanyun Tang, Chris Sereduk, Elizabeth A. Raupach, Patrick Pirrotte, Ritin Sharma, Pilar Ramos, Jeffrey Kiefer, Hongwei Yin, Krystal A. Orlando, William P.D. Hendricks, Jessica D. Lang
Purpose: Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare, aggressive ovarian cancer in young women that is universally driven by loss of the SWI/SNF ATPase subunits SMARCA4 and SMARCA2. A great need exists for effective targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf4fffb94e0c2d32e4dcebc100aa969
https://doi.org/10.1158/1078-0432.c.6525683.v1
https://doi.org/10.1158/1078-0432.c.6525683.v1