Zobrazeno 1 - 10
of 175
pro vyhledávání: '"William P. Murphy"'
Autor:
Gianluca Fontana, Brett Nemke, Yan Lu, Connie Chamberlain, Jae-Sung Lee, Joshua A. Choe, Hongli Jiao, Michael Nelson, Margot Amitrano, Wan-Ju Li, Mark Markel, William L. Murphy
Publikováno v:
Bioactive Materials, Vol 45, Iss , Pp 509-519 (2025)
Osteoarthritis (OA) is a condition that affects the quality of life of millions of patients worldwide. Current clinical treatments, in most cases, lead to cartilage repair with deposition of fibrocartilage tissue, which is mechanically inferior and n
Externí odkaz:
https://doaj.org/article/64e47237b2c745f0a1047ed1bb029f3a
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 9, Pp 1513-1527 (2024)
Abstract OATP1B facilitates the uptake of xenobiotics into hepatocytes and is a prominent target for drug–drug interactions (DDIs). Reduced systemic exposure of OATP1B substrates has been reported following multiple‐dose rifampicin; one explanati
Externí odkaz:
https://doaj.org/article/5334c41546ee4ed98d6b56aaabccd6a8
Autor:
Rachel A. Carroll, Edward S. Rice, William J. Murphy, Leslie A. Lyons, Francoise Thibaud-Nissen, Lyndon M. Coghill, William F. Swanson, Karen A. Terio, Tyler Boyd, Wesley C. Warren
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The fishing cat, Prionailurus viverrinus, faces a population decline, increasing the importance of maintaining healthy zoo populations. Unfortunately, zoo-managed individuals currently face a high prevalence of transitional cell carcinoma (T
Externí odkaz:
https://doaj.org/article/72ae249a5a97496cb3fe943ec456335f
Autor:
Craig P. Collins, Lam T. Khuat, Gail D. Sckisel, Logan V. Vick, Christine M. Minnar, Cordelia Dunai, Catherine T. Le, Brendan D. Curti, Marka Crittenden, Alexander Merleev, Michael Sheng, Nelson J. Chao, Emanual Maverakis, Spencer R. Rosario, Arta M. Monjazeb, Bruce R. Blazar, Dan L. Longo, Robert J. Canter, William J. Murphy
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The thymus is the central organ involved with T-cell development and the production of naïve T cells. During normal aging, the thymus undergoes marked involution, reducing naïve T-cell output and resulting in a predominance of long-lived memory T c
Externí odkaz:
https://doaj.org/article/1e288536df9248b1a327800dd3a6007e
Autor:
Daniel J Hellenbrand, Charles M Quinn, Zachariah J Piper, Ryan T Elder, Raveena R Mishra, Taylor L Marti, Phoebe M Omuro, Rylie M Roddick, Jae Sung Lee, William L Murphy, Amgad S Hanna
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 6, Pp 1308-1317 (2024)
[INLINE:1] After spinal cord injury, there is an extensive infiltration of immune cells, which exacerbates the injury and leads to further neural degeneration. Therefore, a major aim of current research involves targeting the immune response as a tre
Externí odkaz:
https://doaj.org/article/026b4788f0ef4aa0aeaf0028d5154190
Autor:
Maneesh Dave, Atul Dev, Rodrigo A. Somoza, Nan Zhao, Satish Viswanath, Pooja Rani Mina, Prathyush Chirra, Verena Carola Obmann, Ganapati H. Mahabeleshwar, Paola Menghini, Blythe Durbin-Johnson, Jan Nolta, Christopher Soto, Abdullah Osme, Lam T. Khuat, William J. Murphy, Arnold I. Caplan, Fabio Cominelli
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-16 (2024)
Abstract Mesenchymal stem cells (MSCs) are novel therapeutics for the treatment of Crohn’s disease. However, their mechanism of action is unclear, especially in disease-relevant chronic models of inflammation. Thus, we used SAMP-1/YitFc (SAMP), a c
Externí odkaz:
https://doaj.org/article/1f75ae80e5f44a7d8febf9ed44b27251
Autor:
William J Murphy, Robert J Canter, Cordelia Dunai, Michael S Kent, Sean J Judge, Robert B Rebhun, Aryana M Razmara, Lauren E Farley, Eric G Johnson, Marshall Lammers, Rayna M Harris, Khurshid R Iranpur, C Titus Brown
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Natural killer (NK) cells are cytotoxic cells capable of recognizing heterogeneous cancer targets without prior sensitization, making them promising prospects for use in cellular immunotherapy. Companion dogs develop spontaneous cancers in
Externí odkaz:
https://doaj.org/article/9e4917da394e47e0a918f2987771283a
Autor:
Arta M. Monjazeb, Megan E. Daly, Guillaume Luxardi, Emanual Maverakis, Alexander A. Merleev, Alina I. Marusina, Alexander Borowsky, Amin Mirhadi, Stephen L. Shiao, Laurel Beckett, Shuai Chen, David Eastham, Tianhong Li, Logan V. Vick, Heather M. McGee, Frances Lara, Leslie Garcia, Leigh Anne Morris, Robert J. Canter, Jonathan W. Riess, Kurt A. Schalper, William J. Murphy, Karen Kelly
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Stereotactic ablative radiotherapy (SABR) is a standard-of-care for medically-inoperable-early-stage non-small cell lung cancer (NSCLC). One third of patients progress and chemotherapy is rarely used in this population. We questioned if addi
Externí odkaz:
https://doaj.org/article/28952647439e48d680160b1ba89a37c4
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)
Abstract
Externí odkaz:
https://doaj.org/article/5ca5e5db755d44eca81b9a71482bfe55
Autor:
William A. Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D. Guy, Manal F. Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Honkakoski, Kim L. R. Brouwer
Publikováno v:
Hepatology Communications, Vol 8, Iss 3 (2024)
Background:. NAFLD is highly prevalent with limited treatment options. Bile acids (BAs) increase in the systemic circulation and liver during NAFLD progression. Changes in plasma membrane localization and zonal distribution of BA transporters can inf
Externí odkaz:
https://doaj.org/article/aac573e3c0734319af4532863a1f9a55