Zobrazeno 1 - 10
of 44
pro vyhledávání: '"William P. Malachowski"'
Autor:
Mary Sexton, William P. Malachowski, Glenn P. A. Yap, Diana Rachii, Greg Feldman, Andrew T. Krasley, Zhilin Chen, My Anh Tran, Kalyn Wiley, Alexandra Matei, Samantha Petersen, Sabrina Tran Tien
Publikováno v:
J Org Chem
Novel phenanthridinone analogs with an all-carbon quaternary stereocenter have been enantioselectively synthesized using the Birch-Heck sequence. Flat phenanthridinone structures have extensive bioactivity, but consequently also suffer from poor ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50afe350b680fdcd7e23b8b7252f967a
https://europepmc.org/articles/PMC9382569/
https://europepmc.org/articles/PMC9382569/
Autor:
William P. Malachowski, James B. DuHadaway, Alexander J. Muller, Khoa N. Pham, Ariel Lewis-Ballester, George C. Prendergast, Jenny Wai, Eesha Sheikh, Syun Ru Yeh, Maria Winters, Shorouk O. Badir
Publikováno v:
European Journal of Medicinal Chemistry. 162:455-464
Tryptophan (Trp) catabolizing enzymes play an important and complex role in the development of cancer. Significant evidence implicates them in a range of inflammatory and immunosuppressive activities. Whereas inhibitors of indoleamine 2,3-dioxygenase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde0f747f69acc3e3a1c0f32f6063811
https://doi.org/10.1016/j.ejmech.2018.11.010
https://doi.org/10.1016/j.ejmech.2018.11.010
Autor:
William P. Malachowski, Jamie Ford, Peter A. Beckmann, Gilbert J. Sloan, Arnold L. Rheingold, Joseph M. Bohen, Clelia W. Mallory, Kraig A. Wheeler, Frank B. Mallory, Xianlong Wang, Andrew R. McGhie, Steven T. Szewczyk
Publikováno v:
Solid State Nuclear Magnetic Resonance. :1-11
We report a variety of experiments and calculations and their interpretations regarding methyl group (CH3) rotation in samples of pure 3-methylglutaric anhydride (1), pure 3-methylglutaric acid (2), and samples where the anhydride is slowly absorbing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0145f8bcce045dec7e4e6b2f195df9b5
https://doi.org/10.1016/j.ssnmr.2017.01.004
https://doi.org/10.1016/j.ssnmr.2017.01.004
Publikováno v:
Organic letters. 20(7)
A new enantioselective desymmetrizing Mizoroki-Heck reaction is reported. The process affords high yields and enantioselectivities of tricyclic structures containing all-carbon quaternary stereocenters. The substrates for the reaction are efficiently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489dba59557a52a9f2881f71e24cfab7
https://pubmed.ncbi.nlm.nih.gov/29561159
https://pubmed.ncbi.nlm.nih.gov/29561159
Autor:
Andrew R. McGhie, Arnold L. Rheingold, Steven T. Szewczyk, Peter A. Beckmann, Gilbert J. Sloan, Jamie Ford, William P. Malachowski, Curtis E. Moore
Publikováno v:
Chemphyschem : a European journal of chemical physics and physical chemistry. 19(18)
We report solid-state nuclear magnetic resonance 1 H spin-lattice relaxation, single-crystal X-ray diffraction, powder X-ray diffraction, field emission scanning electron microscopy, and differential scanning calorimetry in solid samples of 2-ethylan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54609f1638e3ef31045ac3b28b70a4ac
https://pubmed.ncbi.nlm.nih.gov/29956438
https://pubmed.ncbi.nlm.nih.gov/29956438
Autor:
George C. Prendergast, William P. Malachowski, Alexander J. Muller, Peggy Scherle, Arpita Mondal
Publikováno v:
International review of cell and molecular biology. 336
The tryptophan catabolic enzyme indoleamine 2,3-dioxygenase-1 (IDO1) has attracted enormous attention in driving cancer immunosuppression, neovascularization, and metastasis. IDO1 suppresses local CD8+ T effector cells and natural killer cells and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b53e3d95e64f56c3b459497047ed91
https://pubmed.ncbi.nlm.nih.gov/29413890
https://pubmed.ncbi.nlm.nih.gov/29413890
Small-molecule inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) are emerging at the vanguard of experimental agents in oncology. Here, pioneers of this new drug class provide a bench-to-bedside review on preclinical validation of IDO1 as a cancer t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513cc7aabdb382a91fc1b1e43950d20c
https://europepmc.org/articles/PMC6021761/
https://europepmc.org/articles/PMC6021761/
Publikováno v:
Tetrahedron Letters. 56:6073-6076
The first report of Lewis acid use in intramolecular Rauhut–Currier reactions is described. Titanium Lewis acids lead to rapid Rauhut–Currier reactions in the case of two classic substrates. More importantly, titanium and tin Lewis acids were the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b54dce1a9d521fd4f0fe65ef0c51a3f0
https://doi.org/10.1016/j.tetlet.2015.09.069
https://doi.org/10.1016/j.tetlet.2015.09.069
Autor:
William P. Malachowski, Jason R. Schmink, Alexis van Venrooy, Zhuowen Yu, Mary E. Sexton, Ami Okazaki
Publikováno v:
Tetrahedron Letters. 60:151057
Herein, we report the selective mono-γ-arylation of 7-methoxy-4-methylcoumarin under palladium-catalyzed conditions. The Buchwald G3 pre-catalyst in conjunction with either the Xantphos or N-Xantphos ligand proves to be highly reactive, engaging ary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4fe647d5e429d0f000f71b233565523
https://doi.org/10.1016/j.tetlet.2019.151057
https://doi.org/10.1016/j.tetlet.2019.151057
Publikováno v:
International Journal of Tryptophan Research, Vol 2013, Iss 6, Pp 35-45 (2013)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::ab45cc339c2005cab30eb8a472393956
http://www.la-press.com/the-tumor-selective-cytotoxic-agent--lapachone-is-a-potent-inhibitor-o-article-a3836
http://www.la-press.com/the-tumor-selective-cytotoxic-agent--lapachone-is-a-potent-inhibitor-o-article-a3836