Zobrazeno 1 - 10
of 49
pro vyhledávání: '"William P. Kolb"'
Autor:
Paul J. Steinhardt, William P. Kolb, Terry C. Wallace, Luca Bindi, Paul D. Asimow, G. Nelson Eby
Publikováno v:
Proc Natl Acad Sci U S A
The first test explosion of a nuclear bomb, the Trinity test of 16 July 1945, resulted in the fusion of surrounding sand, the test tower, and copper transmission lines into a glassy material known as “trinitite.” Here, we report the discovery, in
Publikováno v:
The Journal of Experimental Medicine
Large numbers of neuritic plaques (NP), largely composed of a fibrillar insoluble form of the β-amyloid peptide (Aβ), are found in the hippocampus and neocortex of Alzheimer's disease (AD) patients in association with damaged neuronal processes, in
Autor:
Diego Mastroeni, Heather Kolody, Brian Leonard, Phillip Cao, Marwan N. Sabbagh, William P. Kolb, Rena Li, Andrew Grover, Geoffrey L. Ahern, Linda Vedders, Joseph Rogers
Publikováno v:
Neurobiology of aging. 27(12)
Brain deposits of amyloid beta peptide (Abeta) have been a diagnostic hallmark of Alzheimer's disease (AD) for nearly a century. Recent studies have demonstrated that Abeta is also present in peripheral blood. Here, we present evidence that circulati
Autor:
Robert J. Wyatt, Phillip R. Morrow, John D. Tamerius, William P. Kolb, Douglas G. Matsell, Shane Roy
Publikováno v:
American journal of kidney diseases : the official journal of the National Kidney Foundation. 17(3)
In most instances of acute poststreptococcal glomerulonephritis (APSGN), activation of the complement system occurs, as reflected by decreased levels of the complement proteins C3, C5, and properdin (P). Recent studies implicate terminal complement c
Publikováno v:
Clinical and experimental dermatology. 15(1)
Plasma from 16 patients with psoriasis and 12 healthy control subjects were measured for iC3b, C4d, and Bb fragments generated by complement activation. Plasma concentrations for iC3b, C4d, and Bb fragments were found to be significantly increased in
Autor:
Stephen W. Hunt, Juanita G. Dalzell, Barbara M. Matteucci, Robert Roubey, William P. Kolb, Gordon D. Ross, William Reed, Barry L. Myones
Publikováno v:
Immunogenetics. 31(3)
Human B and T lymphoblastoid cell lines were shown to synthesize C5. C5 synthesis was quantitated with an enzyme-linked immunosorbent assay (ELISA) that utilized a pool of C5-specific monoclonal antibodies (mAbs). Some level of C5 synthesis was detec
Autor:
William P. Kolb, Alan Stall, Sharon Sasaki, Liangru Shi, Julia A. Ember, Feng Jun Luan, Stephanie Windman, Charles C-Y Shih, Edward L. Morgan
Publikováno v:
Immunopharmacology. 49:91
Publikováno v:
The Journal of Immunology. 121:1232-1238
Two different radiographic contrast media (RCM), iothalamate and iodipamide, induced the activation of several complement (C) components in normal, genetically C2-deficient and agammaglobulinemic human sera in vitro. This activation was dose dependen
Publikováno v:
The Journal of Immunology. 113:479-488
The following experimental observations were made: 1) The C9 hemolytic dose response curve is sigmoidal; 2) C9 binding to EAC1-8 at low C9 input shows a definite time lag; 3) binding of three to six C9 molecules is required for the formation of a fun
Publikováno v:
Investigative Radiology. 11:303-308
Evidence is presented for the activation of serum complement by contrast media, in vitro and in vivo. Activation as a function of concentration was measured and the increasing order of effectiveness was found to be metrizamide, iothalamate, diatrizoa