Zobrazeno 1 - 10
of 57
pro vyhledávání: '"William P. Katt"'
Autor:
Cody Aplin, Kara A. Zielinski, Suzette Pabit, Deborah Ogunribido, William P. Katt, Lois Pollack, Richard A. Cerione, Shawn K. Milano
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Transglutaminase 2 (TG2) is a GTP-binding, protein-crosslinking enzyme that has been investigated as a therapeutic target for Celiac disease, neurological disorders, and aggressive cancers. TG2 has been suggested to adopt two conformational
Externí odkaz:
https://doaj.org/article/c30285b37bdd4cb1aa637ea1b450312e
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
Differentiating canine acanthomatous ameloblastoma (CAA) from oral squamous cell carcinoma (OSCC) based on routine histopathology can be challenging. We have previously shown that more than 95% of CAAs harbor an HRAS p.Q61R somatic mutation, while OS
Externí odkaz:
https://doaj.org/article/8f774505db4a4052935547c3058f92fe
Autor:
Santiago Peralta, Gerald E. Duhamel, William P. Katt, Kristiina Heikinheimo, Andrew D. Miller, Faraz Ahmed, Angela L. McCleary-Wheeler, Jennifer K. Grenier
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Ameloblastomas are odontogenic tumors that are rare in people but have a relatively high prevalence in dogs. Because canine acanthomatous ameloblastomas (CAA) have clinicopathologic and molecular features in common with human ameloblastomas
Externí odkaz:
https://doaj.org/article/d5c7128c160c48f0a26af1a3052b03de
Autor:
Dean C. Singleton, Anne-Lise Dechaume, Pamela M. Murray, William P. Katt, Bruce C. Baguley, Euphemia Y. Leung
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Glutamine serves as an important nutrient with many cancer types displaying glutamine dependence. Following cellular uptake glutamine is converted to glutamate in a reaction catalysed by mitochondrial glutaminase. This glutamate h
Externí odkaz:
https://doaj.org/article/610f5156d2c24e1e8f92504261190da4
Autor:
Michael J. Lukey, Ahmad A. Cluntun, William P. Katt, Miao-chong J. Lin, Joseph E. Druso, Sekar Ramachandran, Jon W. Erickson, Henry H. Le, Zhihan-Emily Wang, Bryant Blank, Kai Su Greene, Richard A. Cerione
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 76-88.e7 (2019)
Summary: Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GLS. The importance of the other isozyme, GLS2, in cancer has remained unclear, and it has been described as a tumor suppressor in some context
Externí odkaz:
https://doaj.org/article/febd3a642aa746e1bfa7a9c5d1e5c5be
Publikováno v:
Veterinary and Comparative Oncology. 21:138-144
Oral squamous cell carcinoma (OSCC) is the most common oral epithelial malignancy in dogs. It exhibits locally aggressive biological behaviour with the potential to metastasize, and a reported 1-year survival rate of 0% when left untreated. Expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cab21fe095fdd5041f282862eeddb35
https://doi.org/10.1111/vco.12869
https://doi.org/10.1111/vco.12869
PDF file, 48KB, Graph showing 968 potency at multiple doses when 968 is added to GAC before or after inorganic phosphate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45fca221a287f2aeada0dfce66fcaafb
https://doi.org/10.1158/1535-7163.22497460
https://doi.org/10.1158/1535-7163.22497460
PDF file, 50KB, Time dependence of two compounds, 35 and 40, showing that their activity decreases when incubated with GAC for 10 or 20 minutes prior to beginning the enzymatic reaction in the assay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f190e35210eb99293ff6eb5fc9d3fc7
https://doi.org/10.1158/1535-7163.22497457.v1
https://doi.org/10.1158/1535-7163.22497457.v1
PDF file, 294KB, Complete list of compounds examined in the recombinant GAC assay, and % inhibition determined against the enzyme for each compound.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8690fc081fde3a0547f615c65b71e9
https://doi.org/10.1158/1535-7163.22497451
https://doi.org/10.1158/1535-7163.22497451