Zobrazeno 1 - 10
of 19
pro vyhledávání: '"William P. Gilks"'
Publikováno v:
F1000Research, Vol 5 (2016)
As part of a study into the molecular genetics of sexually dimorphic complex traits, we used next-generation sequencing to obtain data on genomic variation in an outbred laboratory-adapted fruit fly (Drosophila melanogaster) population. We successful
Externí odkaz:
https://doaj.org/article/53068cf2b7744ebbb174a976facdf048
Autor:
Mark S. Hill, Edward H. Morrow, Max Reuter, Ilona Flis, Filip Ruzicka, Fiona C. Ingleby, William P. Gilks, Kevin Fowler, Tanya M. Pennell
The evolution of sexual dimorphism is constrained by a shared genome, leading to ‘sexual antagonism’ where different alleles at given loci are favoured by selection in males and females. Despite its wide taxonomic incidence, we know little about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caed7d6b319ff6e3882f84ad9ed158ff
https://doi.org/10.1101/117176
https://doi.org/10.1101/117176
Publikováno v:
Trends in Genetics. 30:453-463
Understanding the genetic architecture of disease is an enormous challenge, and should be guided by evolutionary principles. Recent studies in evolutionary genetics show that sexual selection can have a profound influence on the genetic architecture
Autor:
William P. Gilks
Publikováno v:
eLS
There is long-standing evidence for gene-by-sex interactions in disease risk, which can now be tested in genome-wide association studies with participant numbers in the hundreds of thousands. Contemporary methods start with a separate test for each s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e04a56a349bd271095db5f5c32bcad
http://sro.sussex.ac.uk/id/eprint/65388/1/sex_differences_in_disease_genetics.pdf
http://sro.sussex.ac.uk/id/eprint/65388/1/sex_differences_in_disease_genetics.pdf
Autor:
William P. Gilks, Michael Gill, Derek W. Morris, Aiden Corvin, Elizabeth Cummings, Emma H. Allott, Gary Donohoe
Publikováno v:
Neuroscience Letters. 468:229-233
Schizophrenia is a heritable mental disorder with a complex genetic aetiology potentially implicating glutamatergic dysfunction. Following a search for functionally relevant genes with evidence of linkage to schizophrenia, we selected HOMER2 for as a
Autor:
Daniel G. Healy, Kirsten Harvey, Kerrie Venner, Sonia Gandhi, Adrian T. Saurin, William P. Gilks, David S. Latchman, Robert J. Harvey, Janice L. Holton, Martin Smith, Andrew J. Lees, Patrick M. Abou-Sleiman, Simon Eaton, Miratul M. K. Muqit, Nicholas W. Wood, Antoni Matilla, Emma Deas, Peter J. Parker, Tamas Revesz
Publikováno v:
Journal of Neurochemistry. 98:156-169
Following our identification of PTEN-induced putative kinase 1 (PINK1) gene mutations in PARK6-linked Parkinson's disease (PD), we have recently reported that PINK1 protein localizes to Lewy bodies (LBs) in PD brains. We have used a cellular model sy
Autor:
L. H. Eunson, Andrew B. Singleton, Kailash P. Bhatia, Nicola Pavese, William P. Gilks, John Lynch, Janice L. Holton, David J. Brooks, Mary B. Davis, Paola Piccini, Shushant Jain, Tamas Revesz, J. R. Vaughan, Patrick M. Abou-Sleiman, Juliet Gayton, Regina Katzenschlager, Graham Lennox, Nicholas W. Wood, Daniel G. Healy, Niall Quinn, David Nicholl, Vaneesha Gibbons, Andrew J. Lees, Sonia Gandhi, Naheed L. Khan, Mary G. Sweeney, M Ganguly
Publikováno v:
Brain. 128:2786-2796
We have established that the frequency of LRRK2 mutations in a series of 118 cases of familial Parkinson's disease is 5.1%. In the largest family with autosomal dominant, late-onset Parkinson's disease where affected subjects share a Y1699C missense
Publikováno v:
F1000Research. 5:2644
As part of a study into the molecular genetics of sexually dimorphic complex traits, we used high-throughput sequencing to obtain data on genomic variation in an outbred laboratory-adapted fruit fly (Drosophila melanogaster) population. We successful
There are significant differences in the biology of males and females, ranging from biochemical pathways to behavioural responses, which are relevant to modern medicine. Broad-sense heritability estimates differ between the sexes for many common medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3be1dd49032d524a8236799f81b4069
https://doi.org/10.1101/000414
https://doi.org/10.1101/000414
Publikováno v:
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 13(7)
Objectives: SNP rs2473277 upstream of the cell division cycle 42 (CDC42) gene was associated with schizophrenia in a recent genome-wide association study (GWAS). Reduced expression of CDC42 in schizophrenia has previously been reported. Our objective