Characterization and propagation of tumor initiating cells derived from colorectal liver metastases: trials, tribulations and a cautionary note.

Autor: Mark I James, Lynne M Howells, Ankur Karmokar, Jennifer A Higgins, Peter Greaves, Hong Cai, Ashley Dennison, Matthew Metcalfe, Giuseppe Garcea, David M Lloyd, David P Berry, William P Steward, Karen Brown

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0117776 (2015)

Tumor initiating cells (TIC) are increasingly being put forward as a potential target for intervention within colorectal cancer. Whilst characterisation and outgrowth of these cells has been extensively undertaken in primary colorectal cancers, few d

Externí odkaz: https://doaj.org/article/40f79e0c4d4847f99e3347938183afd6

Data from Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention

Autor: Andreas J. Gescher, William P. Steward, David Hemingway, Andrew Miller, Giuseppe Garcea, Ashley Dennison, Karen Brown, Debbie Marsden, Tim H. Marczylo, Kevin West, Hong Cai, David P. Berry, Sarah Thomasset

Naturally occurring anthocyanins possess colorectal cancer chemopreventive properties in rodent models. We investigated whether mirtocyan, an anthocyanin-rich standardized bilberry extract, causes pharmacodynamic changes consistent with chemopreventi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::176ff5fc7aadf8877c58efb1dfd97348
https://doi.org/10.1158/1940-6207.c.6544596

Supplementary Tables 1-5, Methods from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials

Autor: Karen Brown, William P. Steward, Andreas J. Gescher, Edwina N. Scott

Supplementary Tables 1-5, Methods from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f94e505d6d9edccf08ea5fc24ab1716
https://doi.org/10.1158/1940-6207.22526601

Supplementary Table 2 from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials

Autor: Karen Brown, William P. Steward, Andreas J. Gescher, Edwina N. Scott

Supplementary Table 2 from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51f922d7b28ba68f33708a96116b531
https://doi.org/10.1158/1940-6207.22526604.v1

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma

Autor: Duncan I. Jodrell, Daniel H. Palmer, Sarah Halford, J. Evans, Lisa V. Hampson, Balaji Venugopal, Robert McLeod, Mirela Hategan, Natalie Cook, Helen Turner, Donna Michelle Smith, Bristi Basu, Aarthi Gopinathan, Michael Nebozhyn, D. Alan Anthoney, David A. Tuveson, William P. Steward, David Propper, Hayley Farmer-Hall

Publikováno v: Cook, N, Basu, B, Smith, D M, Gopinathan, A, Evans, J, Steward, W P, Palmer, D, Propper, D, Venugopal, B, Hategan, M, Anthoney, D A, Hampson, L V, Nebozhyn, M, Tuveson, D, Farmer-Hall, H, Turner, H, McLeod, R, Halford, S & Jodrell, D 2018, ' A phase i trial of the c-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma ', British Journal of Cancer, vol. 118, no. 6, pp. 793-801 . https://doi.org/10.1038/bjc.2017.495
British Journal of Cancer

Background: The Notch pathway is frequently activated in cancer. Pathway inhibition by g-secretase inhibitors has been shown to be effective in pre-clinical models of pancreatic cancer, in combination with gemcitabine. Methods: A multi-centre, non-ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45456c3b7d8810792b891ee0674468b1
https://doi.org/10.1038/bjc.2017.495