Data from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials

Autor: Karen Brown, William P. Steward, Andreas J. Gescher, Edwina N. Scott

In view of safety concerns surrounding the use of pharmaceuticals such as nonsteroidal anti-inflammatory drugs and tamoxifen as cancer chemopreventive agents, potentially innocuous phytochemicals derived from the diet are considered attractive altern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c12018a819db43ae1d52efb08013b002
https://doi.org/10.1158/1940-6207.c.6545148.v1

Supplementary Figure 1 from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials

Autor: Karen Brown, William P. Steward, Andreas J. Gescher, Edwina N. Scott

Supplementary Figure 1 from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f084627576019faa81a3b4f2a8a8dc
https://doi.org/10.1158/1940-6207.22526607.v1

Perspective on this Article from Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention

Autor: Andreas J. Gescher, William P. Steward, David Hemingway, Andrew Miller, Giuseppe Garcea, Ashley Dennison, Karen Brown, Debbie Marsden, Tim H. Marczylo, Kevin West, Hong Cai, David P. Berry, Sarah Thomasset

Perspective on this Article from Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c299b22113c84bbdbbaed6e59e7d00
https://doi.org/10.1158/1940-6207.22525143.v1

Distribution and metabolism of [14C]-resveratrol in human prostate tissue after oral administration of a 'dietary-achievable' or 'pharmacological' dose: what are the implications for anticancer activity?

Autor: Masood A. Khan, Karen Brown, Michael A. Malfatti, Edwina N. Scott, William P. Steward, Emma Parrott, Robert G. Britton, Ted J. Ognibene, Hong Cai

Publikováno v: The American Journal of Clinical Nutrition

Background The dietary polyphenol resveratrol prevents various malignancies in preclinical models, including prostate cancer. Despite attempts to translate findings to humans, gaps remain in understanding pharmacokinetic-pharmacodynamic relations and

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https://doi.org/10.1093/ajcn/nqaa414

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma

Autor: Duncan I. Jodrell, Daniel H. Palmer, Sarah Halford, J. Evans, Lisa V. Hampson, Balaji Venugopal, Robert McLeod, Mirela Hategan, Natalie Cook, Helen Turner, Donna Michelle Smith, Bristi Basu, Aarthi Gopinathan, Michael Nebozhyn, D. Alan Anthoney, David A. Tuveson, William P. Steward, David Propper, Hayley Farmer-Hall

Publikováno v: Cook, N, Basu, B, Smith, D M, Gopinathan, A, Evans, J, Steward, W P, Palmer, D, Propper, D, Venugopal, B, Hategan, M, Anthoney, D A, Hampson, L V, Nebozhyn, M, Tuveson, D, Farmer-Hall, H, Turner, H, McLeod, R, Halford, S & Jodrell, D 2018, ' A phase i trial of the c-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma ', British Journal of Cancer, vol. 118, no. 6, pp. 793-801 . https://doi.org/10.1038/bjc.2017.495
British Journal of Cancer

Background: The Notch pathway is frequently activated in cancer. Pathway inhibition by g-secretase inhibitors has been shown to be effective in pre-clinical models of pancreatic cancer, in combination with gemcitabine. Methods: A multi-centre, non-ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45456c3b7d8810792b891ee0674468b1
https://doi.org/10.1038/bjc.2017.495