Zobrazeno 1 - 10
of 124
pro vyhledávání: '"William P Martin"'
Autor:
Carel W le Roux, Neil G Docherty, Lars Fändriks, Meera Nair, William P Martin, Vadim Zhernovkov, Naomi Fearon, Hans Eckhardt, Janet McCormack, Catherine Godson, Eoin Patrick Brennan
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
Introduction Roux-en-Y gastric bypass surgery (RYGB) reduces albuminuria and the long-term incidence of end-stage renal disease in patients with obesity and diabetes. Preclinical modeling in experimental diabetic kidney disease demonstrates that impr
Externí odkaz:
https://doaj.org/article/77cfb63081b94a10ba87892cd973b091
Publikováno v:
Expert Review of Vaccines, Vol 23, Iss 1, Pp 205-212 (2024)
Introduction Clinical trials of personalized cancer vaccines have shown that on-demand therapies that are manufactured for each patient, result in activated T cell responses against individual tumor neoantigens. However, their use has been traditiona
Externí odkaz:
https://doaj.org/article/c49a5329643540508e3c44e5426a9e1f
Autor:
Aimee E. Mattei, Andres H. Gutierrez, Soorya Seshadri, Jacob Tivin, Matt Ardito, Amy S. Rosenberg, William D. Martin, Anne S. De Groot
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTIn silico immunogenicity risk assessment has been an important step in the development path for many biologic therapeutics, including monoclonal antibodies. Even if the source of a given biologic is ‘fully human’, T cell epitopes that are
Externí odkaz:
https://doaj.org/article/d3ac97f35912434aae9b77e2b10534c0
Autor:
Brian J. Roberts, Aimee E. Mattei, Kristina E. Howard, James L. Weaver, Hao Liu, Sandra Lelias, William D. Martin, Daniela Verthelyi, Eric Pang, Katie J. Edwards, Anne S. De Groot
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Advances in synthetic peptide synthesis have enabled rapid and cost-effective peptide drug manufacturing. For this reason, peptide drugs that were first produced using recombinant DNA (rDNA) technology are now being produced using solid- and liquid-p
Externí odkaz:
https://doaj.org/article/674dd4b85a844bff9f2eb55deb7c7e13
Autor:
Natalie Lorenz, Reuben McGregor, Alana L. Whitcombe, Prachi Sharma, Ciara Ramiah, Francis Middleton, Michael G. Baker, William J. Martin, Nigel J. Wilson, Amy W. Chung, Nicole J. Moreland
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110558- (2024)
Summary: Understanding the immune profile of acute rheumatic fever (ARF), a serious post-infectious sequelae of Streptococcal pyogenes (group A Streptococcus [GAS]), could inform disease pathogenesis and management. Circulating cytokines, immunoglobu
Externí odkaz:
https://doaj.org/article/b13c75f917df48d4a74aa75b9fe44bec
Impact of time‐restricted feeding on kidney injury in male rats with experimental metabolic syndrome
Publikováno v:
Experimental Physiology, Vol 108, Iss 7, Pp 925-931 (2023)
Abstract Disruptions to circadian rhythm may be implicated in the pathogenesis of metabolic syndrome (Met‐S). For example, eating during an extended period of the day may negatively impact the circadian rhythms governing metabolic control, contribu
Externí odkaz:
https://doaj.org/article/adf0419b32e44dcf98ae49928662d831
Publikováno v:
Wellcome Open Research, Vol 8 (2024)
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are filtered and secreted to their primary site of action in the proximal tubule of the kidney. At this site, SGLT2 inhibitors also reduce renal elimination of ketone bodies, a finding implicated in t
Externí odkaz:
https://doaj.org/article/647708c7bb654119b9fa817e41902cb6
Autor:
Nazir M. Khan, Martha E. Diaz-Hernandez, William N. Martin, Bhakti Patel, Samir Chihab, Hicham Drissi
Publikováno v:
PeerJ, Vol 11, p e16553 (2023)
Background Osteoarthritis (OA) is a debilitating joints disease affecting millions of people worldwide. As OA progresses, chondrocytes experience heightened catabolic activity, often accompanied by alterations in the extracellular environment’s osm
Externí odkaz:
https://doaj.org/article/21f826ef7df743389e7ec3a65070d744
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Biologics developers are moving beyond antibodies for delivery of a wide range of therapeutic interventions. These non-antibody modalities are often based on ‘natural’ protein scaffolds that are modified to deliver bioactive sequences. Both human
Externí odkaz:
https://doaj.org/article/fb0855ea9b154b43a5269a481f59c86f
Autor:
Loraine Schwander, Max Brabender, Natalia Mrnjavac, Jessica L. E. Wimmer, Martina Preiner, William F. Martin
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Serpentinization in hydrothermal vents is central to some autotrophic theories for the origin of life because it generates compartments, reductants, catalysts and gradients. During the process of serpentinization, water circulates through hydrotherma
Externí odkaz:
https://doaj.org/article/ad75bd4675dc4d0eaf137c6edc38307d