Zobrazeno 1 - 10
of 16
pro vyhledávání: '"William P D Hendricks"'
Autor:
Shukmei Wong, E J Ehrhart, Samuel Stewart, Victoria Zismann, Jacob Cawley, Rebecca Halperin, Natalia Briones, Keith Richter, Karthigayini Sivaprakasam, Nieves Perdigones, Tania Contente-Cuomo, Salvatore Facista, Jeffrey M Trent, Muhammed Murtaza, Chand Khanna, William P D Hendricks
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0264986 (2022)
Cancer genomic heterogeneity presents significant challenges for understanding oncogenic processes and for cancer's clinical management. Variation in driver mutation frequency between patients with the same tumor type as well as within an individual
Externí odkaz:
https://doaj.org/article/62e231b6cdc64d4faee96910a1df5788
Autor:
Patricia M LoRusso, Aleksandar Sekulic, Jeffrey A Sosman, Winnie S Liang, John Carpten, David W Craig, David B Solit, Alan H Bryce, Jeffrey A Kiefer, Jessica Aldrich, Sara Nasser, Rebecca Halperin, Sara A Byron, Mary Jo Pilat, Scott A Boerner, Diane Durecki, William P D Hendricks, Daniel Enriquez, Tyler Izatt, Jonathan Keats, Christophe Legendre, Svetomir N Markovic, Amy Weise, Fatima Naveed, Jessica Schmidt, Gargi D Basu, Shobana Sekar, Jonathan Adkins, Erica Tassone, Karthigayini Sivaprakasam, Victoria Zismann, Valerie S Calvert, Emanuel F Petricoin, Leslie Anne Fecher, Christopher Lao, J Paul Eder, Nicholas J Vogelzang, Jane Perlmutter, Mark Gorman, Barbara Manica, Lisa Fox, Nicholas Schork, Daniel Zelterman, Michelle DeVeaux, Richard W Joseph, C Lance Cowey, Jeffrey M Trent
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0248097 (2021)
Although combination BRAF and MEK inhibitors are highly effective for the 40-50% of cutaneous metastatic melanomas harboring BRAFV600 mutations, targeted agents have been ineffective for BRAFV600wild-type (wt) metastatic melanomas. The SU2C Genomics-
Externí odkaz:
https://doaj.org/article/ea286e5ad5d3466fb04534c8639561db
Autor:
Raffaella Soldi, Tithi Ghosh Halder, Alexis Weston, Trason Thode, Kevin Drenner, Rhonda Lewis, Mohan R Kaadige, Shreyesi Srivastava, Sherin Daniel Ampanattu, Ryan Rodriguez Del Villar, Jessica Lang, Hariprasad Vankayalapati, Bernard Weissman, Jeffrey M Trent, William P D Hendricks, Sunil Sharma
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235705 (2020)
Mutations of the SWI/SNF chromatin remodeling complex occur in 20% of all human cancers, including ovarian cancer. Approximately half of ovarian clear cell carcinomas (OCCC) carry mutations in the SWI/SNF subunit ARID1A, while small cell carcinoma of
Externí odkaz:
https://doaj.org/article/1c9aae36c158461f9a747a08ebf0de0f
Autor:
William P D Hendricks, Victoria Zismann, Karthigayini Sivaprakasam, Christophe Legendre, Kelsey Poorman, Waibhav Tembe, Nieves Perdigones, Jeffrey Kiefer, Winnie Liang, Valerie DeLuca, Mitchell Stark, Alison Ruhe, Roe Froman, Nicholas S Duesbery, Megan Washington, Jessica Aldrich, Mark W Neff, Matthew J Huentelman, Nicholas Hayward, Kevin Brown, Douglas Thamm, Gerald Post, Chand Khanna, Barbara Davis, Matthew Breen, Alexander Sekulic, Jeffrey M Trent
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007589 (2018)
Canine malignant melanoma, a significant cause of mortality in domestic dogs, is a powerful comparative model for human melanoma, but little is known about its genetic etiology. We mapped the genomic landscape of canine melanoma through multi-platfor
Externí odkaz:
https://doaj.org/article/fb48d4dcfc8546dabf55f455902f3e75
Autor:
Giselle L. Saulnier Sholler, Genevieve Bergendahl, Elizabeth C. Lewis, Jacqueline Kraveka, William Ferguson, Abhinav B. Nagulapally, Karl Dykema, Valerie I. Brown, Michael S. Isakoff, Joseph Junewick, Deanna Mitchell, Jawhar Rawwas, William Roberts, Don Eslin, Javier Oesterheld, Randal K. Wada, Devang Pastakia, Virginia Harrod, Kevin Ginn, Raya Saab, Kevin Bielamowicz, Jason Glover, Eugenia Chang, Gina K. Hanna, Daniel Enriquez, Tyler Izatt, Rebecca F. Halperin, Abigail Moore, Sara A. Byron, William P. D. Hendricks, Jeffrey M. Trent
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Background Children with relapsed central nervous system (CNS tumors), neuroblastoma, sarcomas, and other rare solid tumors face poor outcomes. This prospective clinical trial examined the feasibility of combining genomic and transcriptomic
Externí odkaz:
https://doaj.org/article/aabaaa1d731d43219ab2b7d7fb61c753
Autor:
Jessica D. Lang, Tuong Vi V. Nguyen, Maren K. Levin, Page E. Blas, Heather L. Williams, Esther San Roman Rodriguez, Natalia Briones, Claudius Mueller, William Selleck, Sarah Moore, Victoria L. Zismann, William P. D. Hendricks, Virginia Espina, Joyce O'Shaughnessy
BACKGROUND A subset of triple-negative breast cancers (TNBCs) have homologous recombination deficiency with upregulation of compensatory DNA repair pathways. PIKTOR, a combination of TAK-228 (TORC1/2 inhibitor) and TAK-117 (PI3Kα inhibitor), is hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::998612c7cdd34111d380c535d7596fb1
https://doi.org/10.21203/rs.3.rs-2864312/v1
https://doi.org/10.21203/rs.3.rs-2864312/v1
Autor:
Jacqueline M. Kraveka, Elizabeth C. Lewis, Genevieve Bergendahl, William Ferguson, Javier Oesterheld, Elizabeth Kim, Abhinav B. Nagulapally, Karl J. Dykema, Valerie I. Brown, William D. Roberts, Deanna Mitchell, Don Eslin, Derek Hanson, Michael S. Isakoff, Randal K. Wada, Virginia L. Harrod, Jawhar Rawwas, Gina Hanna, William P. D. Hendricks, Sara A. Byron, Matija Snuderl, Jonathan Serrano, Jeffrey M. Trent, Giselle L. Saulnier Sholler
Publikováno v:
Cancer Reports. 5
Survival for patients with high-risk neuroblastoma (HRNB) remains poor despite aggressive multimodal therapies.To study the feasibility and safety of incorporating a genomic-based targeted agent to induction therapy for HRNB as well as the feasibilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b5f56659c6f32720ca19358fcb4af4
https://doi.org/10.1002/cnr2.1616
https://doi.org/10.1002/cnr2.1616
Autor:
Patricia Filippsen Favaro, Samuel D. Stewart, Bradon R. McDonald, Jacob Cawley, Tania Contente-Cuomo, Shukmei Wong, William P. D. Hendricks, Jeffrey M. Trent, Chand Khanna, Muhammed Murtaza
Publikováno v:
Scientific reports. 12(1)
Comparative studies of naturally occurring canine cancers have provided new insight into many areas of cancer research. Development and validation of circulating tumor DNA (ctDNA) analysis in pet dogs can help address diagnostic needs in veterinary a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c65b8a7951887d581167b85770f7df
https://pubmed.ncbi.nlm.nih.gov/35428782
https://pubmed.ncbi.nlm.nih.gov/35428782
Network Rewiring in Cancer: Applications to Melanoma Cell Lines and the Cancer Genome Atlas Patients
Autor:
Kuan-Fu Ding, Darren Finlay, Hongwei Yin, William P. D. Hendricks, Chris Sereduk, Jeffrey Kiefer, Aleksandar Sekulic, Patricia M. LoRusso, Kristiina Vuori, Jeffrey M. Trent, Nicholas J. Schork
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Frontiers in Genetics
Frontiers in Genetics
Genes do not work in isolation, but rather as part of networks that have many feedback and redundancy mechanisms. Studying the properties of genetic networks and how individual genes contribute to overall network functions can provide insight into ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2506376ba2f1a33236c9d8ef860c8dbc
https://www.frontiersin.org/article/10.3389/fgene.2018.00228/full
https://www.frontiersin.org/article/10.3389/fgene.2018.00228/full
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1706
Cancer is a complex genetic disease that can arise through the stepwise accumulation of mutations in oncogenes and tumor suppressor genes in a variety of different tissues. While the varied landscapes of mutations driving common cancer types such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ddc0db84ac3552f495174dd6c76cb1e7
https://pubmed.ncbi.nlm.nih.gov/29423809
https://pubmed.ncbi.nlm.nih.gov/29423809