Zobrazeno 1 - 10
of 149
pro vyhledávání: '"William P, Sheffield"'
Autor:
Marie‐Christine Bouton, Margarethe Geiger, William P Sheffield, James A Irving, David A Lomas, Sihong Song, Ritvik S Satyanarayanan, Liqiang Zhang, Grant McFadden, Alexandra R Lucas
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 6, Pp 1-5 (2023)
Abstract In the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are regulated by serine proteinases, but we rarely consider the unique protease inhibitors
Externí odkaz:
https://doaj.org/article/9884bec85769492f83aef84706a3bcf0
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Even with extensive transfusion support, trauma-induced bleeding often leads to death. Early intervention may improve outcomes, yet which blood products, factor concentrates, or other drugs constitute optimal treatment is unclear. Patients w
Externí odkaz:
https://doaj.org/article/432c6c783d1e480fba8aef1bf2870d7b
Autor:
Varsha Bhakta, Mostafa Hamada, Amy Nouanesengsy, Jessica Lapierre, Darian L. Perruzza, William P. Sheffield
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Coagulation Factor XIa (FXIa) is an emerging target for antithrombotic agent development. The M358R variant of the serpin alpha-1 antitrypsin (AAT) inhibits both FXIa and other proteases. Our aim was to enhance the specificity of AAT M358R f
Externí odkaz:
https://doaj.org/article/4657582d6d9b43608bea58dc7f4701aa
Autor:
Rosi Bissinger, Polina Petkova-Kirova, Olga Mykhailova, Per-Arne Oldenborg, Elena Novikova, David A. Donkor, Thomas Dietz, Abdulla Al Mamun Bhuyan, William P. Sheffield, Marijke Grau, Ferruh Artunc, Lars Kaestner, Jason P. Acker, Syed M. Qadri
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-10 (2020)
Abstract Background Thrombospondin-1 (TSP-1), a Ca2+-binding trimeric glycoprotein secreted by multiple cell types, has been implicated in the pathophysiology of several clinical conditions. Signaling involving TSP-1, through its cognate receptor CD4
Externí odkaz:
https://doaj.org/article/7086c71dd11f4222a9579a9a93259a1b
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
BackgroundIon and metal homeostasis are critical to red blood cell physiology and Inductively Coupled Plasma (ICP) is a decades old approach to pursue elemental analysis. Recent evolution of ICP has resulted in its coupling to mass spectrometry (MS)
Externí odkaz:
https://doaj.org/article/62d9f632006f4c60848b7f769ee7cb0d
Autor:
Sebastian Himbert, Angelo D’Alessandro, Syed M. Qadri, Michael J. Majcher, Todd Hoare, William P. Sheffield, Michihiro Nagao, John F. Nagle, Maikel C. Rheinstädter
Publikováno v:
PLoS ONE, Vol 17, Iss 8 (2022)
An important mechanical property of cells is the membrane bending modulus, κ. In the case of red blood cells (RBCs) there is a composite membrane consisting of a cytoplasmic membrane and an underlying spectrin network. Literature values of κ are pu
Externí odkaz:
https://doaj.org/article/a217a39fcb974129ab66029967d5e111
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Alpha-1 antitrypsin (AAT, also known as alpha-1 proteinase inhibitor or SERPINA1) is the most abundant member of the serpin superfamily found in human plasma. The naturally occurring variant AAT M358R, altered at the P1 position of the critical react
Externí odkaz:
https://doaj.org/article/69c66b2ff33a45bfadd5454b86064ee8
Autor:
Sebastian Himbert, Syed M. Qadri, William P. Sheffield, Peter Schubert, Angelo D’Alessandro, Maikel C. Rheinstädter
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Blood banks around the world store blood components for several weeks ensuring its availability for transfusion medicine. Red blood cells (RBCs) are known to undergo compositional changes during storage, which may impact the cells’ function and eve
Externí odkaz:
https://doaj.org/article/3ef5864f252f4669bdab478548b1ed83
Autor:
Benjamin M Scott, Wadim L Matochko, Richard F Gierczak, Varsha Bhakta, Ratmir Derda, William P Sheffield
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238969 (2020)
[This corrects the article DOI: 10.1371/journal.pone.0084491.].
Externí odkaz:
https://doaj.org/article/4e70cb041e254a179dfb17ba66abac10
Publikováno v:
BMC Biotechnology, Vol 18, Iss 1, Pp 1-13 (2018)
Abstract Background Hirudin is a potent thrombin inhibitor but its antithrombotic properties are offset by bleeding side-effects. Because hirudin’s N-terminus must engage thrombin’s active site for effective inhibition, fusing a cleavable peptide
Externí odkaz:
https://doaj.org/article/67bcc24117d247fbb185167c383efbe2