Zobrazeno 1 - 10
of 42
pro vyhledávání: '"William P, Forrest"'
Autor:
Diana Chang, Julie Hunkapiller, Tushar Bhangale, Jens Reeder, Kiran Mukhyala, Jennifer Tom, Amy Cowgill, Jan Vogel, William F. Forrest, Zia Khan, Amy Stockwell, Mark I. McCarthy, Tracy L. Staton, Julie Olsson, Cecile T. J. Holweg, Dorothy S. Cheung, Hubert Chen, Matthew J. Brauer, Robert R. Graham, Timothy Behrens, Mark S. Wilson, Joseph R. Arron, David F. Choy, Brian L. Yaspan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Genome-wide association studies (GWAS) have identified many common variant loci associated with asthma susceptibility, but few studies investigate the genetics underlying moderate-to-severe asthma risk. Here, we present a whole-genome sequen
Externí odkaz:
https://doaj.org/article/5fa4592260184e79882d694bb0b47a44
Autor:
Martin Weber, Sang-Won Min, Tom Truong, Jeffrey Hung, Stephanie Dale, Mike Reichelt, Savita Ubhayakar, Carol Cain-Hom, Miriam Baca, Zhiyu Jiang, Qingling Li, Robert Brendza, Han Lin, Chung Kung, William F. Forrest, Cristine Quiason-Huynh, Wendy Sandoval, Buyun Chen, Yuzhong Deng, Amy Easton, Oded Foreman, Abdoulaye Sene, Baris Bingol
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Mutations in the GBA1 gene encoding glucocerebrosidase (GCase) are linked to Gaucher (GD) and Parkinson’s Disease (PD). Since some GD and PD patients develop ocular phenotypes, we determined whether ocular phenotypes might result from impa
Externí odkaz:
https://doaj.org/article/08dc67cbf02f4f9ab4c713dcac4d0867
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 7, p e1009131 (2021)
Human immunogenetic variation in the form of HLA and KIR types has been shown to be strongly associated with a multitude of immune-related phenotypes. However, association studies involving immunogenetic loci most commonly involve simple analyses of
Externí odkaz:
https://doaj.org/article/eb1deaaeb2a8463897dfba4588dedffb
Autor:
Jean-Philippe Fortin, Jenille Tan, Karen E. Gascoigne, Peter M. Haverty, William F. Forrest, Michael R. Costa, Scott E. Martin
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-25 (2019)
Abstract Background Genome-wide loss-of-function screens using the CRISPR/Cas9 system allow the efficient discovery of cancer cell vulnerabilities. While several studies have focused on correcting for DNA cleavage toxicity biases associated with copy
Externí odkaz:
https://doaj.org/article/da41017688c44f37813cd692b3acf27a
Autor:
David S. Hewings, Johanna Heideker, Taylur P. Ma, Andrew P. AhYoung, Farid El Oualid, Alessia Amore, Gregory T. Costakes, Daniel Kirchhofer, Bradley Brasher, Thomas Pillow, Nataliya Popovych, Till Maurer, Carsten Schwerdtfeger, William F. Forrest, Kebing Yu, John Flygare, Matthew Bogyo, Ingrid E. Wertz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Deubiquitinases are proteases that cleave after the C-terminus of ubiquitin to hydrolyze ubiquitin chains and cleave ubiquitin from substrates. Here the authors describe a reactive-site-centric chemoproteomics approach to studying deubiquitinase acti
Externí odkaz:
https://doaj.org/article/a36fd9ead45149f0b851c7d214b80597
Autor:
Jennifer A. Tom, Jens Reeder, William F. Forrest, Robert R. Graham, Julie Hunkapiller, Timothy W. Behrens, Tushar R. Bhangale
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-12 (2017)
Abstract Background Large sample sets of whole genome sequencing with deep coverage are being generated, however assembling datasets from different sources inevitably introduces batch effects. These batch effects are not well understood and can be du
Externí odkaz:
https://doaj.org/article/cd005446c0714a70933f7fb8a1664523
Autor:
Andrew Brunskill, Rui Fang, Paul L. Walsh, Mikhail Reibarkh, Nathan D. Rudd, William P. Forrest, Sachin Mittal
Publikováno v:
Molecular Pharmaceutics. 17:1734-1747
Injectable sustained release dosage forms have emerged as desirable therapeutic routes for patients that require life-long treatments. The prevalence of drug molecules with low aqueous solubility and bioavailability has added momentum toward the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f519d9335872bdd7dc851c613c27201
https://doi.org/10.1021/acs.molpharmaceut.0c00208
https://doi.org/10.1021/acs.molpharmaceut.0c00208
Autor:
Alena Bensussan, Roy Helmy, Bindesh Shrestha, Hernando J. Olivos, Vivek Shah, Elizabeth E. Pierson, William P. Forrest, Ryan S. Teller, Anthony J. Midey, Seth P. Forster
Publikováno v:
Pharmaceutical Research. 37
Desorption electrospray ionization mass spectrometry imaging (DESI-MSI) coupled with gas-phase ion mobility spectrometry was used to characterize the drug distribution in polymeric implants before and after exposure to accelerated in vitro release (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3987547d67cbf25a8f0ff3451cf677a
https://doi.org/10.1007/s11095-020-02823-x
https://doi.org/10.1007/s11095-020-02823-x
Autor:
Nathan D, Rudd, Mikhail, Reibarkh, Rui, Fang, Sachin, Mittal, Paul L, Walsh, Andrew P J, Brunskill, William P, Forrest
Publikováno v:
Molecular pharmaceutics. 17(5)
Injectable sustained release dosage forms have emerged as desirable therapeutic routes for patients that require life-long treatments. The prevalence of drug molecules with low aqueous solubility and bioavailability has added momentum toward the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31dcf1deed2949b40afaaae6c32074f2
https://pubmed.ncbi.nlm.nih.gov/32267708
https://pubmed.ncbi.nlm.nih.gov/32267708
Autor:
Peter G. Dormer, W. Peter Wuelfing, Mikhail Reibarkh, William P. Forrest, Roy Helmy, Paul L. Walsh, Nathan D. Rudd, R. Thomas Williamson
Publikováno v:
Molecular Pharmaceutics.
Novel treatment routes are emerging for an array of diseases and afflictions. Complex dosage forms, based on active pharmaceutical ingredients (APIs) with previously undesirable physicochemical characteristics, are becoming mainstream and actively pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd781831ec8682b38df97d44b8a675db
https://doi.org/10.1021/acs.molpharmaceut.9b00958
https://doi.org/10.1021/acs.molpharmaceut.9b00958