Zobrazeno 1 - 10
of 26
pro vyhledávání: '"William O. Ogle"'
Publikováno v:
Journal of Computational Neuroscience. 32:521-538
The application of data-driven time series analysis techniques such as Granger causality, partial directed coherence and phase dynamics modeling to estimate effective connectivity in brain networks has recently gained significant prominence in the ne
Autor:
Jie Yu, Abhinav P. Acharya, Erin R. Boykin, Jianchun Pan, William O. Ogle, Ling Chen, Xiaoyu Pan, Ying Xu, Matthew M. Vernon, Subramaniam S. Govindarajan, Yuan Zhang, Shan Li, Philip A. Barish, James M. O'Donnell
Publikováno v:
Journal of Neurochemistry. 118:784-795
J. Neurochem. (2011) 118, 784–795. Abstract Curcumin, a major active component of Curcuma longa, possesses antioxidant and neuroprotective activities. The present study explores the mechanisms underlying the neuroprotective effect of curcumin again
Autor:
C. Zhang, Jianchun Pan, Matthew M. Vernon, C. Fu, James M. O'Donnell, Ying Xu, R. Wang, Philip A. Barish, Abhinav P. Acharya, S.S. Govindarajan, William O. Ogle, J. Yu, Erin R. Boykin, Ling Chen
Publikováno v:
Neuroscience. 182:71-81
Stress is an unavoidable life experience. It induces mood, cognitive dysfunction and plasticity changes in chronically stressed individuals. Among the various brain regions that have been studied, the hippocampus and amygdala have been observed to ha
Publikováno v:
Mechanisms of Ageing and Development. 132:8-19
We measured changes in gene expression, induced by aging and caloric restriction (CR), in three hippocampal subregions. When analysis included all regions, aging was associated with expression of genes linked to mitochondrial dysfunction, inflammatio
Autor:
Ling Chen, Mengmeng Lin, Ruijie Chen, Jianchun Pan, Bao-Shan Ku, William O. Ogle, Shan Li, Ying Xu, Philip A. Barish, Wenting You, Gaowen Li
Publikováno v:
Pharmacology Biochemistry and Behavior. 94:447-453
Proanthocyanidin is a phenolic product present in plants which has antioxidant, antinociceptive and neuroprotective properties, without inducing significant toxicological effects. The present study tested the hypothesis that low molecular proanthocya
Autor:
Angela L. Lee, M A Winters, Klaus Dinkel, Andrea Nicholas, D Kaufer, Theodore C. Dumas, Robert M. Sapolsky, Zachary Pincus, K L Clark, Deveroux Ferguson, William O. Ogle
Publikováno v:
Nature Neuroscience. 7:947-953
Glucocorticoids, the adrenal steroids released during stress, compromise the ability of neurons to survive neurological injury. In contrast, estrogen protects neurons against such injuries. We designed three genetic interventions to manipulate the ac
Publikováno v:
Bipolar Disorders. 4:117-128
Recent intriguing reports have shown an association between major depression and selective and persistent loss of hippocampal volume, prompting considerable speculation as to its underlying causes. In this paper we focus on the hypothesis that overt
Autor:
William O. Ogle, Robert M. Sapolsky
Publikováno v:
Mechanisms of Ageing and Development. 122:1555-1563
In recent years, the first attempts have been made to apply gene transfer technology to protect neurons from death following neurological insults. There has been sufficient progress in this area that it becomes plausible to consider similar gene ther
Autor:
Bernard Roizman, William O. Ogle
Publikováno v:
Journal of Virology. 73:4305-4315
Earlier studies have shown that (i) the coding domain of the α22 gene encodes two proteins, the 420-amino-acid infected-cell protein 22 (ICP22) and a protein, U S 1.5, which is initiated from methionine 147 of ICP22 and which is colinear with the re
Publikováno v:
Virology. 241(1):37-48
Herpes simplex virus 1 encodes a Fc receptor consisting of glycoproteins E (gE) and I (gI) and two protein kinases specified by UL13 and US3, respectively. We report the following: (i) Antibody to UL13 formed immune complexes containing gE and gI in