Výsledky vyhledávání - "William O. Kline"

Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol

Autor: Sue C. Bodine, Hayung Yang, William O. Kline, Frank J. Panaro

Publikováno v: Journal of Applied Physiology. 102:740-747

Clenbuterol and other β2-adrenergic agonists are effective at inducing muscle growth and attenuating muscle atrophy through unknown mechanisms. This study tested the hypothesis that clenbuterol-induced growth and muscle sparing is mediated through t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddb6ced6f303a63c63d77842069b4c1
https://doi.org/10.1152/japplphysiol.00873.2006

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Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity

Autor: David J. Glass, George D. Yancopoulos, William O. Kline, Mark W. Sleeman, Karen Garcia, Katherine E. Wortley, Jennifer Kintner, Ka-Man V. Lai, Lori C. Gowen, Stanley J. Wiegand, Trevor Stitt

Publikováno v: Nature Medicine. 11:199-205

Genetic ablation of Inppl1, which encodes SHIP2 (SH2-domain containing inositol 5-phosphatase 2), was previously reported to induce severe insulin sensitivity, leading to early postnatal death. In the previous study, the targeting construct left the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b215efee772a1ee775ea09e36a25447e
https://doi.org/10.1038/nm1178

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Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy

Autor: Michael Gonzalez, Trevor Stitt, George D. Yancopoulos, William O. Kline, William Poueymirou, Elizabeth Zlotchenko, Erqian Na, Ka-Man V. Lai, Aris N. Economides, David J. Glass

Publikováno v: Molecular and Cellular Biology. 24:9295-9304

Skeletal muscle atrophy is a severe morbidity caused by a variety of conditions, including cachexia, cancer, AIDS, prolonged bedrest, and diabetes. One strategy in the treatment of atrophy is to induce the pathways normally leading to skeletal muscle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04e8e240816880f2436aebb616f9c7d
https://doi.org/10.1128/mcb.24.21.9295-9304.2004

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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

Autor: John C. Lawrence, Sue C. Bodine, Gretchen L. Stover, David J. Glass, Roy Bauerlein, George D. Yancopoulos, Michael Gonzalez, William O. Kline, Elizabeth Zlotchenko, Angus Scrimgeour, Trevor Stitt

Publikováno v: Nature cell biology. 3(11)

Skeletal muscles adapt to changes in their workload by regulating fibre size by unknown mechanisms. The roles of two signalling pathways implicated in muscle hypertrophy on the basis of findings in vitro, Akt/mTOR (mammalian target of rapamycin) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6ab26eef46a96f9a80b84f4c52d382
https://pubmed.ncbi.nlm.nih.gov/11875443

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Induction of neuronal type nitric oxide synthase in skeletal muscle by chronic electrical stimulation in vivo

Autor: Peter J. Reiser, William O. Kline, Pal L. Vaghy

Publikováno v: Journal of applied physiology (Bethesda, Md. : 1985). 82(4)

Reiser, Peter J., William O. Kline, and Pal L. Vaghy.Induction of neuronal type nitric oxide synthase in skeletal muscle by chronic electrical stimulation in vivo. J. Appl. Physiol. 82(4): 1250–1255, 1997.—Fast-twitch skeletal muscles contain mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3735f2a45dd9a7ef21578ceb91409114
https://pubmed.ncbi.nlm.nih.gov/9104863

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