Výsledky vyhledávání - "William O. Jonsson"

Akademický článek

Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction

Autor: Wenceslao Martinez, Qian Zhang, Melissa A. Linden, Nate Schacher, Sanna Darvish, Emily T. Mirek, Jordan L. Levy, William O. Jonsson, Tracy G. Anthony, Karyn L. Hamilton

Publikováno v: Frontiers in Aging, Vol 3 (2022)

Dietary interventions such as sulfur amino acid restriction (SAAR) target multiple drivers of aging, and show promise for preventing or delaying the onset of chronic diseases. SAAR promotes metabolic health and longevity in laboratory animals. The ef

Externí odkaz: https://doaj.org/article/4c6709b31ba84f44ad1529f8042b1171

Zobrazit plný text záznamu

Kinetic proteomics identifies targeted changes in liver metabolism and the ribo-interactome by dietary sulfur amino acid restriction

Autor: William O. Jonsson, Agnieszka K. Borowik, Atul Pranay, Michael T. Kinter, Emily T. Mirek, Jordan L. Levy, Elizabeth M. Snyder, Benjamin F. Miller, Tracy G. Anthony

Publikováno v: GeroScience.

Dietary sulfur amino acid restriction (SAAR) protects against diet-induced obesity, extends healthspan, and coincides with an overall reduction in hepatic protein synthesis. To explore the underpinnings of SAAR-induced slowed growth and its impact on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54e411ed0836a39081810314c630ecc2
https://doi.org/10.1007/s11357-023-00758-w

Zobrazit plný text záznamu

Circulating metabolite homeostasis achieved through mass action

Autor: Xiaoxuan Li, Sheng Hui, Emily T. Mirek, William O. Jonsson, Tracy G. Anthony, Won Dong Lee, Xianfeng Zeng, Cholsoon Jang, Joshua D. Rabinowitz

Publikováno v: Nature metabolism, vol 4, iss 1
Nat Metab

Homeostasis maintains serum metabolites within physiological ranges. For glucose, this requires insulin, which suppresses glucose production while accelerating its consumption. For other circulating metabolites, a comparable master regulator has yet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51780322b6c287b5d367920c6320f559
https://doi.org/10.1038/s42255-021-00517-1

Zobrazit plný text záznamu

Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific

Autor: William O. Jonsson, Emily T. Mirek, Ronald C. Wek, Tracy G. Anthony

Publikováno v: The FASEB Journal. 36

Dietary removal of an essential amino acid (EAA) triggers the integrated stress response (ISR) in liver. Herein, we explored the mechanisms that activate the ISR and execute changes in transcription and translation according to the missing EAA. Wild-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a7c062c283c9623b326e398cdce95c
https://doi.org/10.1096/fj.202200204rr

Zobrazit plný text záznamu

Mechanisms underlying reduced weight gain in intestinal fatty acid-binding protein (IFABP) null mice

Autor: Natalia María Bottasso Arias, Yin X Zhou, Atreju I. Lackey, Betina Córsico, Tina Chen, Laurie B. Joseph, William O Jonsson, Tracy G. Anthony, Justine M Doran, Judith Storch, Sophia M Zacharisen, Angela M. Gajda

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Am J Physiol Gastrointest Liver Physiol
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

Intestinal-fatty acid binding protein (IFABP; FABP2) is a 15-kDa intracellular protein abundantly present in the cytosol of the small intestinal (SI) enterocyte. High-fat (HF) feeding of IFABP-/- mice resulted in reduced weight gain and fat mass rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a149d9ff91e095dd97b51b2747418b
https://doi.org/10.1152/ajpgi.00120.2019

Zobrazit plný text záznamu

Changes in plasma concentration of kynurenine following intake of branched-chain amino acids are not caused by alterations in muscle kynurenine metabolism

Autor: Tomas Rydenstam, Eva Blomstrand, Björn Ekblom, Jonathan Ponette, William O Jonsson, Michele Azzolini, Karin Söderlund, Oscar Horwath, Jorge L. Ruas

Publikováno v: American journal of physiology. Cell physiology. 322(1)

Administration of branched-chain amino acids (BCAA) has been suggested to enhance mitochondrial biogenesis, including levels of PGC-1α, which may, in turn, alter kynurenine metabolism. Ten healthy subjects performed 60 min of dynamic one-leg exercis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b3a88ff86a41c287ca2a1a7d6c63dd
https://pubmed.ncbi.nlm.nih.gov/34817270

Zobrazit plný text záznamu

Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force

Autor: Thomas Chaillou, Johanna T. Lanner, Jorge L. Ruas, William O Jonsson, Theresa Mader, Estela Santos Alves, Heidi Hynynen, Arthur J. Cheng, Gianluigi Pironti, Baptiste Jude, Daniel C. Andersson, Duarte M. S. Ferreira, Zhengye Liu, Ellinor Kenne, Pasi Tavi

Publikováno v: The FASEB Journal. 35

The hypoxia-inducible nuclear-encoded mitochondrial protein NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) has been demonstrated to decrease oxidative phosphorylation and production of reactive oxygen species in neonatal card

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e63338104ac87a46b9a7bdf6600cb2d
https://doi.org/10.1096/fj.202100066r

Zobrazit plný text záznamu

Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice

Autor: Karyn L. Hamilton, Tracy G. Anthony, Emily T. Mirek, Albert R. Bargoud, Thomas W. Gettys, Ashley P. Pettit, Yongping Wang, William O Jonsson, Ronald C. Wek, Benjamin F. Miller, Frederick F. Peelor, Scot R. Kimball

Publikováno v: The Journal of Nutrition. 147:1031-1040

Background: The phosphorylation of eukaryotic initiation factor 2 (p-eIF2) during dietary amino acid insufficiency reduces protein synthesis and alters gene expression via the integrated stress response (ISR).Objective: We explored whether a Met-rest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b1e708667cfb2c3e54851b8037387af
https://doi.org/10.3945/jn.116.246710

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání