Zobrazeno 1 - 10
of 15
pro vyhledávání: '"William O. C. M. Cookson"'
Autor:
Anca Nastase, Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris-Rosendahl, Yu Zhi Zhang, Xiao-Ming Sun, Spyridon Gennatas, Robert C. Rintoul, Matthew Edwards, Alex Bowman, Tatyana Chernova, Tim Benepal, Eric Lim, Anthony Newman Taylor, Andrew G. Nicholson, Sanjay Popat, Anne E. Willis, Marion MacFarlane, Mark Lathrop, Anne M. Bowcock, Miriam F. Moffatt, William O. C. M. Cookson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Pleural mesothelioma is an aggressive malignancy with limited effective therapies. In order to identify therapeutic targets, we integrated SNP genotyping, sequencing and transcriptomics from tumours and low-passage patient-derived cells. Pre
Externí odkaz:
https://doaj.org/article/f4c03b22d13e4a60887cc31103bca100
Autor:
Long T. Hoang, Clara Domingo‐Sabugo, Elizabeth S. Starren, Saffron A.G. Willis‐Owen, Deborah J. Morris‐Rosendahl, Andrew G. Nicholson, William O. C. M. Cookson, Miriam F. Moffatt
Publikováno v:
Molecular Oncology, Vol 13, Iss 11, Pp 2406-2421 (2019)
Lung cancer is the leading cause of cancer‐related deaths in the world. The most prevalent subtype, accounting for 85% of cases, is non‐small‐cell lung cancer (NSCLC). Lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) are the m
Externí odkaz:
https://doaj.org/article/4a9a508851924fa2ae8044e3fc1ee6d4
Autor:
Anca Nastase, Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris‑Rosendahl, Yu Zhi Zhang, Xiao‑Ming Sun, Spyridon Gennatas, Robert C. Rintoul, Matthew Edwards, Alex Bowman, Tatyana Chernova, Tim Benepal, Eric Lim, Anthony Newman Taylor, Andrew G. Nicholson, Sanjay Popat, Anne E. Willis, Marion MacFarlane, Mark Lathrop, Anne M. Bowcock, Miriam F. Moffatt, William O. C. M. Cookson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/64137690744647169fd468ce09fed777
Autor:
Margherita, Ciano, Giada, Mantellato, Martin, Connolly, Mark, Paul-Clark, Saffron, Willis-Owen, Miriam F, Moffatt, William O C M, Cookson, Jane A, Mitchell, Michael I, Polkey, Simon M, Hughes, Paul R, Kemp, S Amanda, Natanek
Publikováno v:
Scientific Reports
A low quadriceps slow-twitch (ST), oxidative (relative to fast-twitch) fiber proportion is prevalent in chronic diseases such Chronic Obstructive Pulmonary Disease (COPD) and is associated with exercise limitation and poor outcomes. Benefits of an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c08ee0eaa480d8f2587f82d3b063bca2
https://pubmed.ncbi.nlm.nih.gov/31239465
https://pubmed.ncbi.nlm.nih.gov/31239465
Autor:
Saffron A G, Willis-Owen, Anna, Thompson, Paul R, Kemp, Michael I, Polkey, William O C M, Cookson, Miriam F, Moffatt, Samantha A, Natanek
Publikováno v:
Scientific Reports
Skeletal muscle dysfunction is a frequent extra-pulmonary manifestation of Chronic Obstructive Pulmonary Disease (COPD) with implications for both quality of life and survival. The underlying biology nevertheless remains poorly understood. We measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5454cdb420beb7be2329d7a534579da
https://pubmed.ncbi.nlm.nih.gov/30111857
https://pubmed.ncbi.nlm.nih.gov/30111857
Publikováno v:
Genetic epidemiology. 39(5)
Genome-wide association studies (GWAS) have been a standard practice in identifying single nucleotide polymorphisms (SNPs) for disease susceptibility. We propose a new approach, termed integrative GWAS (iGWAS) that exploits the information of gene ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::215e0e57895af9d4780e16445833163e
https://pubmed.ncbi.nlm.nih.gov/25997986
https://pubmed.ncbi.nlm.nih.gov/25997986
Autor:
James A, Traherne, Michael R, Hill, Pirro, Hysi, Mauro, D'Amato, John, Broxholme, Richard, Mott, Miriam F, Moffatt, William O C M, Cookson
Publikováno v:
Human molecular genetics. 12(20)
Polymorphisms in the beta chain of the high affinity receptor for IgE (Fc epsilon RI-beta, MS4A2) are consistently associated with traits underlying asthma and atopy (immunoglobulin E-mediated allergy). However, the causal variants and haplotypes und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d60a659a38e6a9ed9fdcc1faa010dfba
https://pubmed.ncbi.nlm.nih.gov/12944417
https://pubmed.ncbi.nlm.nih.gov/12944417
Autor:
Miriam F, Moffatt, Jennie A, Faux, Susan, Lester, Peter, Paré, James, McCluskey, Randy, Spargo, Alan, James, A William, Musk, William O C M, Cookson
Publikováno v:
Human molecular genetics. 12(6)
The Class II genes of the MHC represent a major locus with quantified effects on atopic (allergic) phenotypes in many studies of westernized Caucasians. Although asthma is considered a disease of western societies, typical components of the asthma ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13478f39539befa1414fca9367260eaa
https://pubmed.ncbi.nlm.nih.gov/12620968
https://pubmed.ncbi.nlm.nih.gov/12620968
Publikováno v:
Cancer. 59:288-291
46 XY gonadal dysgenesis is a syndrome characterized by a female phenotype with streak gonads and complicated by the frequent occurrence of germ cell tumors. The syndrome and the risk of malignant disease occur in female siblings sharing the XY genot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5ab4c65586f38257896cc31e26ae254
https://doi.org/10.1002/1097-0142(19870115)59:2<288::aid-cncr2820590219>3.0.co
https://doi.org/10.1002/1097-0142(19870115)59:2<288::aid-cncr2820590219>3.0.co
Autor:
Despoina Manousaki, Lavinia Paternoster, Marie Standl, Miriam F Moffatt, Martin Farrall, Emmanuelle Bouzigon, David P Strachan, Florence Demenais, Mark Lathrop, William O C M Cookson, J Brent Richards
Publikováno v:
PLoS Medicine, Vol 14, Iss 5, p e1002294 (2017)
BackgroundLow circulating vitamin D levels have been associated with risk of asthma, atopic dermatitis, and elevated total immunoglobulin E (IgE). These epidemiological associations, if true, would have public health importance, since vitamin D insuf
Externí odkaz:
https://doaj.org/article/a6294275a6eb4205b09a659d25c208ad