Zobrazeno 1 - 10
of 226
pro vyhledávání: '"William N. Hunter"'
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 37, Iss 3, Pp 338-346 (2024)
Similar to plant pathogens, phloem-feeding insects such as aphids deliver effector proteins inside their hosts that act to promote host susceptibility and enable feeding and infestation. Despite exciting progress toward identifying and characterizing
Externí odkaz:
https://doaj.org/article/473ee87b8f6646cdb53f08ab94acfaca
Autor:
Martin Hagan, Genady Pankov, Ramses Gallegos-Monterrosa, David J. Williams, Christopher Earl, Grant Buchanan, William N. Hunter, Sarah J. Coulthurst
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Many bacterial species use Type VI secretion systems (T6SSs) to deliver anti-bacterial effector proteins into neighbouring bacterial cells, representing an important mechanism of inter-bacterial competition. Specific immunity proteins protec
Externí odkaz:
https://doaj.org/article/fd268456843c48bd9eb09666ffa89e08
Autor:
Alice Dawson, Paul Trumper, Juliana Oliveira de Souza, Holly Parker, Mathew J. Jones, Tim G. Hales, William N. Hunter
Publikováno v:
IUCrJ, Vol 6, Iss 6, Pp 1014-1023 (2019)
Protein-engineering methods have been exploited to produce a surrogate system for the extracellular neurotransmitter-binding site of a heteromeric human ligand-gated ion channel, the glycine receptor. This approach circumvents two major issues: the i
Externí odkaz:
https://doaj.org/article/b4b2b99eb93448a8b34e639dc21ae8fc
Autor:
Pasquale Linciano, Alice Dawson, Ina Pöhner, David M. Costa, Monica S. Sá, Anabela Cordeiro-da-Silva, Rosaria Luciani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Philip Gribbon, Jeanette Reinshagen, Markus Wolf, Birte Behrens, Véronique Hannaert, Paul A. M. Michels, Erika Nerini, Cecilia Pozzi, Flavio di Pisa, Giacomo Landi, Nuno Santarem, Stefania Ferrari, Puneet Saxena, Sandra Lazzari, Giuseppe Cannazza, Lucio H. Freitas-Junior, Carolina B. Moraes, Bruno S. Pascoalino, Laura M. Alcântara, Claudia P. Bertolacini, Vanessa Fontana, Ulrike Wittig, Wolfgang Müller, Rebecca C. Wade, William N. Hunter, Stefano Mangani, Luca Costantino, Maria P. Costi
Publikováno v:
ACS Omega, Vol 2, Iss 9, Pp 5666-5683 (2017)
Externí odkaz:
https://doaj.org/article/5c64fcc1dcb6440098320d12bd53e394
Autor:
Renata V. Bueno, Samuel Davis, Alice Dawson, Pauline W. Ondachi, F. Ivy Carroll, William N. Hunter
Publikováno v:
Acta Crystallographica Section D Structural Biology. 78:353-362
Low-nanomolar binding constants were recorded for a series of six 2′-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogues with acetylcholine-binding protein (AChBP). The crystal structures of three complexes with AChBP reveal details of molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6ea6624b47abdef07b2b471d46f424
https://doi.org/10.1107/s2059798322000754
https://doi.org/10.1107/s2059798322000754
Autor:
Holly P. Parker, Alice Dawson, Mathew J. Jones, Rui Yan, Jie Ouyang, Ran Hong, William N. Hunter
Publikováno v:
Acta crystallographica. Section F, Structural biology communications. 78(Pt 9)
The affinity and thermodynamic parameters for the interactions of two naturally occurring neurotoxins, (+)-anatoxin-a and (−)-hosieine-A, with acetylcholine-binding protein were investigated using a fluorescence-quenching assay and isothermal titra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab6119544d78d9adba9a4dc19492b26
https://pubmed.ncbi.nlm.nih.gov/36048081
https://pubmed.ncbi.nlm.nih.gov/36048081
Publikováno v:
Chembiochem
Bicuculline, a valued chemical tool in neurosciences research, is a competitive antagonist of specific GABA(A) receptors and affects other pentameric ligand gated ion channels including the glycine, nicotinic acetylcholine and 5-hydroxytryptamine typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c6cc4c9f5221ccbc5841842ee10ec7
https://doi.org/10.1002/cbic.201900680
https://doi.org/10.1002/cbic.201900680
Publikováno v:
The Febs Journal
Burkholderia pseudomallei is a serious, difficult to treat Gram‐negative pathogen and an increase in the occurrence of drug‐resistant strains has been detected. We have directed efforts to identify and to evaluate potential drug targets relevant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac4d849b8a990a8fa44073dcd7c9c07
http://europepmc.org/articles/PMC6899670
http://europepmc.org/articles/PMC6899670
Publikováno v:
Acta Crystallogr F Struct Biol Commun
The thick outer membrane (OM) of Gram-negative bacteria performs an important protective role against hostile environments, supports cell integrity, and contributes to surface adhesion and in some cases also to virulence. A major component of the OM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bbf4594059984a2a1a3f8ac316a842
https://doi.org/10.1107/s2053230x19001778
https://doi.org/10.1107/s2053230x19001778
Publikováno v:
Davis, S, Campello, H R, Gallagher, T & Hunter, W N 2020, ' The thermodynamic profile and molecular interactions of a C(9)-cytisine derivative-binding acetylcholine-binding protein from Aplysia californica ', Acta Crystallographica Section F: Structural Biology Communications, vol. 76, pp. 74-80 . https://doi.org/10.1107/S2053230X20001168
Acta Crystallographica. Section F, Structural Biology Communications
Acta Crystallographica. Section F, Structural Biology Communications
The binding of a C(9)-cytisine derivative carrying a 3-(hydroxypropyl) modification to acetylcholine-binding protein was characterized using isothermal titration calorimetry and crystallography.
Cytisine, a natural product with high affinity for
Cytisine, a natural product with high affinity for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a85ad74a9c6cf84657dd565b144950f
https://hdl.handle.net/1983/a9ff6862-bcb7-42d9-b695-463ca61fd356
https://hdl.handle.net/1983/a9ff6862-bcb7-42d9-b695-463ca61fd356
