Zobrazeno 1 - 10
of 259
pro vyhledávání: '"William N Charman"'
Autor:
Jean-Francois Gautier, Nicolas Venteclef, Assam El-Osta, Andrew J Murphy, Darren M Riddy, Helene L Kammoun, Sanja Bosnyak-Gladovic, Rocio De la Fuente Gonzalez, Jon Merlin, Mark Ziemann, Stewart Fabb, Tracie L Pierce, Natalie Diepenhorst, Patricia Rueda, William N Charman, Arthur Christopoulos, Patrick M Sexton, Roger J Summers, Mark A Febbraio, Philippe Delerive, Christopher J Langmead
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 9, Iss 2 (2021)
Externí odkaz:
https://doaj.org/article/4720f931b7654da0bb23e3c27d888fd0
Autor:
Patricia Rueda, Elizabeth Harley, Yao Lu, Gregory D Stewart, Stewart Fabb, Natalie Diepenhorst, Béatrice Cremers, Marie-Hélène Rouillon, Isabelle Wehrle, Anne Geant, Gwladys Lamarche, Katie Leach, William N Charman, Arthur Christopoulos, Roger J Summers, Patrick M Sexton, Christopher J Langmead
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146846 (2016)
Phenotyping of Gprc6a KO mice has shown that this promiscuous class C G protein coupled receptor is variously involved in regulation of metabolism, inflammation and endocrine function. Such effects are described as mediated by extracellular calcium,
Externí odkaz:
https://doaj.org/article/b658292f3cbd438ca68f91442b0499b5
Autor:
Patricia Rueda, Jon Merlin, Stefano Chimenti, Michel Feletou, Jerome Paysant, Paul J. White, Arthur Christopoulos, Patrick M. Sexton, Roger J. Summers, William N. Charman, Lauren T. May, Christopher J. Langmead
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Adenosine A1 receptors (A1R) are a potential target for cardiac injury treatment due to their cardioprotective/antihypertrophic actions, but drug development has been hampered by on-target side effects such as bradycardia and altered renal hemodynami
Externí odkaz:
https://doaj.org/article/76be888ff9584388bd20cd56e08b4643
Autor:
Katrin Palm, Christel A. S. Bergström, Tommy B. Andersson, Pär Matsson, Pawel Baranczewski, Kathleen M. Giacomini, William N. Charman, Johan E. Palm
Publikováno v:
Journal of Pharmaceutical Sciences. 110:2-11
This issue of the Journal of Pharmaceutical Sciences is dedicated to Professor Per Artursson and the groundbreaking contributions he has made and continues to make in the Pharmaceutical Sciences. Per is one of the most cited researchers in his field,
Autor:
Michael Bettess, Simon Fisher, James S. Rush, Christopher Davis, Ian H. Frazer, Jonathan B. Baell, Michael P. Brown, Mark Sullivan, Michael P. Jennings, Michael A. McGuckin, Eloise Keeffe, Craig Rayner, Anand Gautam, Philip Kearney, C. Glenn Begley, Brett Carter, William N. Charman, Michael W. Parker, Mark R. Ashton, Brett Roberts, Angel F. Lopez, Darren J. Kelly
Publikováno v:
Science translational medicine. 13(612)
Drug repurposing is promoted as a cost- and time-effective mechanism for providing new medicines. Often, however, there is insufficient consideration by academic researchers of the processes required to ensure that a repurposed drug can be used for a
Autor:
William N. Charman, Aurore Sors, Elisabeth Mocaer, Roger J. Summers, David M. Shackleford, Arthur Christopoulos, Tracie L. Pierce, Christopher J. Langmead, Darren Riddy, Clotilde Mannoury la Cour, Patrick M. Sexton, Anna E. Cook
Publikováno v:
Neuropharmacology. 144:244-255
The histamine H3 receptor is a G protein-coupled receptor (GPCR) drug target that is highly expressed in the CNS, where it acts as both an auto- and hetero-receptor to regulate neurotransmission. As such, it has been considered as a relevant target i
Autor:
Natalie L. Trevaskis, Given Lee, Alistair Escott, Kian Liun Phang, Jiwon Hong, Enyuan Cao, Kasiram Katneni, Susan A. Charman, Sifei Han, William N. Charman, Anthony R. J. Phillips, John A. Windsor, Christopher J. H. Porter
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 11 (2020)
Frontiers in Physiology, Vol 11 (2020)
The intestinal lymphatic system transports fluid, immune cells, dietary lipids, and highly lipophilic drugs from the intestine to the systemic circulation. These transport functions are important to health and when dysregulated contribute to patholog
Autor:
Andrew N. Keller, Cameron J. Nowell, Anna E. Cook, Massimo Sabatini, Patrick M. Sexton, Katie Leach, Tracie L. Pierce, Philippe Pastoureau, Natalie Diepenhorst, Patricia Rueda, William N. Charman, Christopher J. Langmead, Arthur Christopoulos, Roger J. Summers
Publikováno v:
British Journal of Pharmacology. 175:4095-4108
Background and purpose Strontium ranelate, a drug approved and until recently used for the treatment of osteoporosis, mediates its effects on bone at least in part via the calcium-sensing (CaS) receptor. However, it is not known whether bone-targeted
Autor:
Patricia Rueda, Sanja Bosnyak-Gladovic, Jon Merlin, Christopher J. Langmead, Philippe Delerive, Mark A. Febbraio, Nicolas Venteclef, William N. Charman, Roger J. Summers, Rocio De la Fuente Gonzalez, Jean-François Gautier, Arthur Christopoulos, Stewart A. Fabb, Assam El-Osta, Helene L. Kammoun, Tracie L. Pierce, Andrew J. Murphy, Patrick M. Sexton, Mark Ziemann, Darren Riddy, Natalie Diepenhorst
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 9, Iss 2 (2021)
BMJ Open Diabetes Research & Care
BMJ Open Diabetes Research & Care, 2021, 9 (2), pp.e002285. ⟨10.1136/bmjdrc-2021-002285⟩
BMJ Open Diabetes Research & Care, BMJ Journals, 2021, 9 (2), pp.e002285. ⟨10.1136/bmjdrc-2021-002285⟩
BMJ Open Diabetes Research & Care
BMJ Open Diabetes Research & Care, 2021, 9 (2), pp.e002285. ⟨10.1136/bmjdrc-2021-002285⟩
BMJ Open Diabetes Research & Care, BMJ Journals, 2021, 9 (2), pp.e002285. ⟨10.1136/bmjdrc-2021-002285⟩
IntroductionA potential role for the orphan G protein-coupled receptor, GPR21, in linking immune cell infiltration into tissues and obesity-induced insulin resistance has been proposed, although limited studies in mice are complicated by non-selectiv
Autor:
Francis C. K. Chiu, David M. Shackleford, Karen L. White, Sergio Wittlin, Sriraghavan Kamaraj, Qingjie Zhao, Petros Papastogiannidis, Jonathan L. Vennerstrom, Eileen Ryan, Heinrich Urwyler, Christian Scheurer, Christopher D. Hein, Manickam Dhanasekaran, Vivek J. Bulbule, Lin Zhou, Helena Barker, Yuxiang Dong, Julia Morizzi, Susan A. Charman, Jacques Chollet, Xiaofang Wang, William N. Charman, Hugues Matile, Yuanqing Tang
Publikováno v:
Journal of Medicinal Chemistry. 60:2654-2668
Building on insights gained from the discovery of the antimalarial ozonide arterolane (OZ277), we now describe the structure–activity relationship (SAR) of the antimalarial ozonide artefenomel (OZ439). Primary and secondary amino ozonides had highe