Zobrazeno 1 - 10
of 53
pro vyhledávání: '"William N Beavers"'
Autor:
Javiera Norambuena, Hassan Al-Tameemi, Hannah Bovermann, Jisun Kim, William N Beavers, Eric P Skaar, Dane Parker, Jeffrey M Boyd
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011393 (2023)
To gain a better insight of how Copper (Cu) ions toxify cells, metabolomic analyses were performed in S. aureus strains that lacks the described Cu ion detoxification systems (ΔcopBL ΔcopAZ; cop-). Exposure of the cop- strain to Cu(II) resulted in
Externí odkaz:
https://doaj.org/article/3f1de80caeeb4e4e89cb47459d3ed5dc
Autor:
William N. Beavers, Matthew J. Munneke, Alex R. Stackhouse, Jeffrey A. Freiberg, Eric P. Skaar
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Aminoglycoside antibiotics rely on the proton motive force to enter the bacterial cell, and facultative anaerobes like Staphylococcus aureus can shift energy generation from respiration to fermentation, becoming tolerant of aminoglycosides.
Externí odkaz:
https://doaj.org/article/d2b7f002f9714c049cf6cabaad2d64bc
Autor:
Lillian J. Juttukonda, William N. Beavers, Daisy Unsihuay, Kwangho Kim, Gleb Pishchany, Kyle J. Horning, Andy Weiss, Hassan Al-Tameemi, Jeffrey M. Boyd, Gary A. Sulikowski, Aaron B. Bowman, Eric P. Skaar
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Metals are essential nutrients that all living organisms acquire from their environment. While metals are necessary for life, excess metal uptake can be toxic; therefore, intracellular metal levels are tightly regulated in bacterial cells. S
Externí odkaz:
https://doaj.org/article/1260e5a12a7c4059be846aa784f59aa4
Autor:
Joseph P. Zackular, Reece J. Knippel, Christopher A. Lopez, William N. Beavers, C. Noel Maxwell, Walter J. Chazin, Eric P. Skaar
Publikováno v:
mSphere, Vol 5, Iss 2 (2020)
ABSTRACT Clostridioides difficile is a spore-forming bacterium that causes severe colitis and is a major public health threat. During infection, C. difficile toxin production results in damage to the epithelium and a hyperinflammatory response. The i
Externí odkaz:
https://doaj.org/article/58e89e011997490d95225cdd11918de3
Autor:
Christopher A. Lopez, William N. Beavers, Andy Weiss, Reece J. Knippel, Joseph P. Zackular, Walter Chazin, Eric P. Skaar
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT The intestines house a diverse microbiota that must compete for nutrients to survive, but the specific limiting nutrients that control pathogen colonization are not clearly defined. Clostridioides difficile colonization typically requires pr
Externí odkaz:
https://doaj.org/article/58d3b414beb14d489a54738e17fe4a93
Autor:
William N. Beavers, Andrew J. Monteith, Venkataraman Amarnath, Raymond L. Mernaugh, L. Jackson Roberts, Walter J. Chazin, Sean S. Davies, Eric P. Skaar
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Staphylococcus aureus infects every niche of the human host. In response to microbial infection, vertebrates have an arsenal of antimicrobial compounds that inhibit bacterial growth or kill bacterial cells. One class of antimicrobial compoun
Externí odkaz:
https://doaj.org/article/8d48f172b9184d079ef7539080bca2d8
Autor:
Caroline M. Grunenwald, Jacob E. Choby, Lillian J. Juttukonda, William N. Beavers, Andy Weiss, Victor J. Torres, Eric P. Skaar
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT Manganese (Mn) is an essential micronutrient critical for the pathogenesis of Staphylococcus aureus, a significant cause of human morbidity and mortality. Paradoxically, excess Mn is toxic; therefore, maintenance of intracellular Mn homeosta
Externí odkaz:
https://doaj.org/article/60f1432fa64645f791d315ca384e153c
Autor:
Zachery R. Lonergan, Brittany L. Nairn, Jiefei Wang, Yen-Pang Hsu, Laura E. Hesse, William N. Beavers, Walter J. Chazin, Jonathan C. Trinidad, Michael S. VanNieuwenhze, David P. Giedroc, Eric P. Skaar
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 2009-2018.e6 (2019)
Summary: Acinetobacter baumannii is an important nosocomial pathogen capable of causing wound infections, pneumonia, and bacteremia. During infection, A. baumannii must acquire Zn to survive and colonize the host. Vertebrates have evolved mechanisms
Externí odkaz:
https://doaj.org/article/20909d2dfa1a429390eb5ab0218db2a6
Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus
Autor:
Kelsey Voss, Allison E. Sewell, Evan S. Krystofiak, Katherine N. Gibson-Corley, Arissa C. Young, Jacob H. Basham, Ayaka Sugiura, Emily N. Arner, William N. Beavers, Dillon E. Kunkle, Megan E. Dickson, Gabriel A. Needle, Eric P. Skaar, W. Kimryn Rathmell, Michelle J. Ormseth, Amy S. Major, Jeffrey C. Rathmell
Publikováno v:
Science Immunology. 8
T cells in systemic lupus erythematosus (SLE) exhibit multiple metabolic abnormalities. Excess iron can impair mitochondria and may contribute to SLE. To gain insights into this potential role of iron in SLE, we performed a CRISPR screen of iron hand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ec8050bf8475384d48058f8264e92df
https://doi.org/10.1126/sciimmunol.abq0178
https://doi.org/10.1126/sciimmunol.abq0178
Autor:
Magdalene K. Ameka, William N. Beavers, Ciara M. Shaver, Lorraine B. Ware, Vern Eric Kerchberger, Kelly Q. Schoenfelt, Lili Sun, Tatsuki Koyama, Eric P. Skaar, Lev Becker, Alyssa H. Hasty
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7417
Adipocyte iron overload is a maladaptation associated with obesity and insulin resistance. The objective of the current study was to determine whether and how adipose tissue macrophages (ATMs) regulate adipocyte iron concentrations and whether this i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf5d974e88773e63b19ee1934cc9f02