Zobrazeno 1 - 10 of 10 pro vyhledávání: '"William Miller-Little"'
1
Akademický článek
TRAF4 is crucial for ST2+ memory Th2 cell expansion in IL-33–driven airway inflammation
Autor: Jianxin Xiao, Xing Chen, Weiwei Liu, Wen Qian, Katarzyna Bulek, Lingzi Hong, William Miller-Little, Xiaoxia Li, Caini Liu
Publikováno v: JCI Insight, Vol 8, Iss 18 (2023)
Tumor necrosis factor receptor–associated factor 4 (TRAF4) is an important regulator of type 2 responses in the airway; however, the underlying cellular and molecular mechanisms remain elusive. Herein, we generated T cell–specific TRAF4-deficient
Externí odkaz: https://doaj.org/article/846fb741220446f39ca4f33739e31375
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2
Akademický článek
STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis
Autor: Junjie Zhao, Yun Liao, William Miller-Little, Jianxing Xiao, Caini Liu, Xiaoxia Li, Xiao Li, Zizhen Kang
Publikováno v: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-11 (2021)
Abstract Background Multiple sclerosis (MS) is a debilitating neurological disease caused by autoimmune destruction of the myelin sheath. Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the pathogenesis of MS. We and
Externí odkaz: https://doaj.org/article/b776c54cccf345be8e8c3228c536f749
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3
TRAF4 is crucial for the propagation of ST2+ memory Th2 cells in IL-33-mediated type 2 airway inflammation
Autor: Jianxin Xiao, Xing Chen, Weiwei Liu, Wen Qian, Katarzyna Bulek, Lingzi Hong, William Miller-Little, Xiaoxia Li, Caini Liu
Publikováno v: bioRxiv
Tumor necrosis factor receptor (TNF)-associated factor 4 (TRAF4) is an important regulator of type 2 responses in the airway; however, the underlying cellular and molecular mechanisms remain elusive. Herein, we generated T cell-specific TRAF4-deficie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3740a8d6b05825046bf06d19022fbab2
https://doi.org/10.1101/2023.02.11.528093
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5
The Ras GTPase-activating-like protein IQGAP1 bridges Gasdermin D to the ESCRT system to promote IL-1β release via exosomes
Autor: Yun, Liao, Xing, Chen, William, Miller-Little, Han, Wang, Belinda, Willard, Katarzyna, Bulek, Junjie, Zhao, Xiaoxia, Li
Publikováno v: The EMBO journalReferences. 42(1)
IL-1β can exit the cytosol as an exosomal cargo following inflammasome activation in intestinal epithelial cells (IECs) in a Gasdermin D (GSDMD)-dependent manner. The mechanistic connection linking inflammasome activation and the biogenesis of exoso
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03dae6de49dac296cff51f036175c4a2
https://pubmed.ncbi.nlm.nih.gov/36373462
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6
STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis
Autor: Yun Liao, Jianxing Xiao, Xiao Li, Junjie Zhao, Caini Liu, Xiaoxia Li, William Miller-Little, Zizhen Kang
Publikováno v: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-11 (2021)
Journal of Neuroinflammation
Background Multiple sclerosis (MS) is a debilitating neurological disease caused by autoimmune destruction of the myelin sheath. Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the pathogenesis of MS. We and others h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325a864f3302042d25039e81857d808e
https://doaj.org/article/b776c54cccf345be8e8c3228c536f749
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7
Inflammasome-independent functions of AIM2
Autor: William Miller-Little, Junjie Zhao, Xiaoxia Li
Publikováno v: The Journal of Experimental Medicine
In this study, Ma et al. demonstrate that AIM2 negatively regulates the DNA-PK–AKT3 in microglia to control neuroinflammation synergistically induced by cGAS and DNA-PK, thereby preventing the pathogenesis of EAE independent of inflammasome activat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20aca53e3e47c566098f0f47278bd292
https://pubmed.ncbi.nlm.nih.gov/33710283
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8
Estradiol regulates AQP2 expression in the collecting duct: a novel inhibitory role for estrogen receptor α
Autor: Debra L. Irsik, Kelly A. Hyndman, Eileen S. Marks, Rikke Nørregaard, Muhammad Umar Cheema, Yan Wang, Erika I. Boesen, William Miller-Little, Jørgen Frøkiær
Publikováno v: Cheema, M U, Irsik, D L, Wang, Y, Miller-Little, W, Hyndman, K A, Marks, E S, Frøkiær, J, Boesen, E I & Nørregaard, R 2015, ' Estradiol regulates AQP2 expression in the collecting duct; a novel inhibitory role for estrogen receptor α ', American Journal of Physiology: Renal Physiology, vol. 309, no. 4, pp. F305-17 . https://doi.org/10.1152/ajprenal.00685.2014
While there is evidence that sex hormones influence multiple systems involved in salt and water homeostasis, the question of whether sex hormones regulate aquaporin-2 (AQP2) and thus water handling by the collecting duct has been largely ignored. Acc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f7c15a2b209fbfe180369fcbe4ff98
https://doi.org/10.1152/ajprenal.00685.2014
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9
Biochemical and Cellular Determinants of Renal Glomerular Elasticity
Autor: Paul A. Janmey, Borren Moe, Addie E. Embry, Leslie A. Bruggeman, William Miller-Little, Xinying Niu, Christopher A. McCulloch, Christopher Y. Lu, Hamid Mohammadi, R. Tyler Miller, Liping Liu
Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 12, p e0167924 (2016)
The elastic properties of renal glomeruli and their capillaries permit them to maintain structural integrity in the presence of variable hemodynamic forces. Measured by micro-indentation, glomeruli have an elastic modulus (E, Young’s modulus) of 2.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682917267fd8f1c3a2f26551e189ed15
https://pubmed.ncbi.nlm.nih.gov/27942003
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