Zobrazeno 1 - 10
of 98
pro vyhledávání: '"William McDowell"'
Autor:
Sonia Moliner-Cubel, Noemi Bahamontes-Rosa, Ane Rodriguez-Alejandre, Pamela M. Nassau, Argyrides Argyrou, Anshu Bhardwaja, Rachel C. Buxton, David Calvo-Vicente, Bernadette Mouzon, William McDowell, Alfonso Mendoza-Losana, Maria G. Gomez-Lorenzo
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 25, Iss , Pp 100537- (2024)
Target-based approaches have traditionally been used in the search for new anti-infective molecules. Target selection process, a critical step in Drug Discovery, identifies targets that are essential to establish or maintain the infection, tractable
Externí odkaz:
https://doaj.org/article/d92953ce83374169adecd4b1d6033c9a
Autor:
Nick Evans, Ruslan Grygorash, Paul Williams, Andrew Kyle, Terrence Kantner, Ravindra Pathak, XiaoBo Sheng, Fabio Simoes, Hiteshri Makwana, Ricardo Resende, Elena de Juan, Alan Jenkins, David Morris, Aurelie Michelet, Frances Jewitt, Felicity Rudge, Nicolas Camper, Anaïs Manin, William McDowell, Martin Pabst, Antony Godwin, Mark Frigerio, Matthew Bird
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Antibody-drug conjugates (ADCs) have begun to fulfil their promise as targeted cancer therapeutics with ten clinical approvals to date. As the field matures, much attention has focused upon the key factors required to produce safe and efficacious ADC
Externí odkaz:
https://doaj.org/article/e322c470d7fb4d25b6de4ac481fa6602
Autor:
Katherine Griffiths, Uli Binder, William McDowell, Rita Tommasi, Mark Frigerio, William G. Darby, Chris G. Hosking, Lionel Renaud, Matthias Machacek, Peter Lloyd, Arne Skerra, Michael Foley
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1331-1340 (2019)
Single domain antibodies that combine antigen specificity with high tissue penetration are an attractive alternative to conventional antibodies. However, rapid clearance from the bloodstream owing to their small size can be a limitation of therapeuti
Externí odkaz:
https://doaj.org/article/7654a6ff13a34f68ab979ca90ac88158
Autor:
Baoshan Xu, Hua Li, John M Perry, Vijay Pratap Singh, Jay Unruh, Zulin Yu, Musinu Zakari, William McDowell, Linheng Li, Jennifer L Gerton
Publikováno v:
PLoS Genetics, Vol 13, Iss 6, p e1006771 (2017)
Ribosomal DNA is one of the most variable regions in the human genome with respect to copy number. Despite the importance of rDNA for cellular function, we know virtually nothing about what governs its copy number, stability, and sequence in the mamm
Externí odkaz:
https://doaj.org/article/cc89e52923204718b99449af05d6b018
Publikováno v:
Journal of Systemics, Cybernetics and Informatics, Vol 9, Iss 7, Pp 51-57 (2011)
Mechanisms such as triadic closure and preferential attachment drive the evolution of social networks. Many models use these mechanisms to predict future links, and they generate realistic networks with scale-free degree distributions. These social n
Externí odkaz:
https://doaj.org/article/6929d0c0694e4031b2112a67820567d5
Publikováno v:
Issues in Information Systems, Vol 11, Iss 1, Pp 553-558 (2010)
Externí odkaz:
https://doaj.org/article/938a3c0aa0ca4c35adaf58d1c185ad86
Autor:
Xing Ma, Su Wang, Trieu Do, Xiaoqing Song, Mayu Inaba, Yoshiya Nishimoto, Lu-ping Liu, Yuan Gao, Ying Mao, Hui Li, William McDowell, Jungeun Park, Kate Malanowski, Allison Peak, Anoja Perera, Hua Li, Karin Gaudenz, Jeff Haug, Yukiko Yamashita, Haifan Lin, Jian-quan Ni, Ting Xie
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90267 (2014)
The piRNA pathway plays an important role in maintaining genome stability in the germ line by silencing transposable elements (TEs) from fly to mammals. As a highly conserved piRNA pathway component, Piwi is widely expressed in both germ cells and so
Externí odkaz:
https://doaj.org/article/3bd6b439318f44a2bbb14d1ad1e2b311
Autor:
Tania Bose, Kenneth K Lee, Shuai Lu, Baoshan Xu, Bethany Harris, Brian Slaughter, Jay Unruh, Alexander Garrett, William McDowell, Andrew Box, Hua Li, Allison Peak, Sree Ramachandran, Chris Seidel, Jennifer L Gerton
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002749 (2012)
Cohesin is a protein complex known for its essential role in chromosome segregation. However, cohesin and associated factors have additional functions in transcription, DNA damage repair, and chromosome condensation. The human cohesinopathy diseases
Externí odkaz:
https://doaj.org/article/c0c12cfb17d1403db876021ff54eef71
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30698 (2012)
Retinoic Acid (RA) is a small lipophilic signaling molecule essential for embryonic development and adult tissue maintenance. Both an excess of RA and a deficiency of RA can cause pathogenic anomalies, hence it is critical to understand the mechanism
Externí odkaz:
https://doaj.org/article/95359f4b7cba46798d1f5ad22bd15ff8
Autor:
Xiaoxi Wang, Lei Pan, Su Wang, Jian Zhou, William McDowell, Jungeun Park, Jeff Haug, Karen Staehling, Hong Tang, Ting Xie
Publikováno v:
PLoS Genetics, Vol 7, Iss 12, p e1002426 (2011)
Epigenetic regulation plays critical roles in the regulation of cell proliferation, fate determination, and survival. It has been shown to control self-renewal and lineage differentiation of embryonic stem cells. However, epigenetic regulation of adu
Externí odkaz:
https://doaj.org/article/4a7d529f779a49c88188bea3e3c26dec