Zobrazeno 1 - 10
of 30
pro vyhledávání: '"William Mallard"'
Autor:
Jordan P. Lewandowski, James C. Lee, Taeyoung Hwang, Hongjae Sunwoo, Jill M. Goldstein, Abigail F. Groff, Nydia P. Chang, William Mallard, Adam Williams, Jorge Henao-Meija, Richard A. Flavell, Jeannie T. Lee, Chiara Gerhardinger, Amy J. Wagers, John L. Rinn
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
LncRNA loci potentially contain multiple modes that can exert function, including DNA regulatory elements. Here, the authors generated genetic models in mice to dissect the role of the syntenically conserved lncRNA Firre in the context of hematopoies
Externí odkaz:
https://doaj.org/article/ae0f94d7e6434786ac485113730f81c4
Publikováno v:
eLife, Vol 6 (2017)
The spatial organization of RNA within cells is a crucial factor influencing a wide range of biological functions throughout all kingdoms of life. However, a general understanding of RNA localization has been hindered by a lack of simple, high-throug
Externí odkaz:
https://doaj.org/article/87937a28b4ce4872b428be61b44e7ef8
Autor:
Martin Sauvageau, Loyal A Goff, Simona Lodato, Boyan Bonev, Abigail F Groff, Chiara Gerhardinger, Diana B Sanchez-Gomez, Ezgi Hacisuleyman, Eric Li, Matthew Spence, Stephen C Liapis, William Mallard, Michael Morse, Mavis R Swerdel, Michael F D’Ecclessis, Jennifer C Moore, Venus Lai, Guochun Gong, George D Yancopoulos, David Frendewey, Manolis Kellis, Ronald P Hart, David M Valenzuela, Paola Arlotta, John L Rinn
Publikováno v:
eLife, Vol 2 (2013)
Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs in various physiological cond
Externí odkaz:
https://doaj.org/article/5fdb35f4c02f45c69bc508db25a26cb3
Autor:
Leonard I. Zon, Roby Joehanes, Eirini Trompouki, Stephen J. Chanock, Alireza Ghamari, Min-Lee Yang, Song Yang, Seraj N. Grimes, Sierra Tseng, Michael Superdock, Daniel E. Bauer, Divya S. Vinjamur, Victoria Chan, Karen Hoi, Richard A. Young, Sonja Boatman, Teresa V. Bowman, Avik Choudhuri, Brian J. Abraham, John L. Rinn, Santhi K. Ganesh, Alan B. Cantor, Kian Hong Kock, Audrey Sporrij, Barbara Hummel, William Mallard, Paul S. Albert, Asher Lichtig, Yi Zhou, Satish K. Nandakumar, Shinichiro Takahashi, Martha L. Bulyk, Leandro M. Colli
Publikováno v:
Nature Genetics
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nat Genet
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nat Genet
Genome-wide association studies identify genomic variants associated with human traits and diseases. Most trait-associated variants are located within cell-type-specific enhancers, but the molecular mechanisms governing phenotypic variation are less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55bc07dd03b947724044bec1c014c8e
https://doi.org/10.1038/s41588-020-00738-2
https://doi.org/10.1038/s41588-020-00738-2
Autor:
Chiara Gerhardinger, Taeyoung Hwang, Richard A. Flavell, James Lee, Amy J. Wagers, Jordan P. Lewandowski, Adam Williams, Nydia Chang, Abigail F. Groff, Jeannie T. Lee, Jorge Henao-Meija, John L. Rinn, Jill M. Goldstein, William Mallard, Hongjae Sunwoo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
RNA has been classically known to play central roles in biology, including maintaining telomeres, protein synthesis, and in sex chromosome compensation. While thousands of long noncoding RNAs (lncRNAs) have been identified, attributing RNA-based role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca62006ebcf72e850e15cbc6ef901b2
https://doi.org/10.1038/s41467-019-12970-4
https://doi.org/10.1038/s41467-019-12970-4
Autor:
Wei-Jun Qian, Chang Siang Lim, Manoj K. Gupta, Hwee Hui Lau, John L. Rinn, Marina A. Gritsenko, Larry Sai Weng Loo, William Mallard, Nicholas Jackson, Linh Nguyen, Richard D. Smith, Rohit N. Kulkarni, Adrian Kee Keong Teo
Publikováno v:
The Journal of Biological Chemistry
Human embryonic stem cells are a type of pluripotent stem cells (hPSCs) that are used to investigate their differentiation into diverse mature cell types for molecular studies. The mechanisms underlying insulin receptor (IR)-mediated signaling in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a24b4a2043209132786004d4981b44
https://doi.org/10.1016/j.jbc.2021.100495
https://doi.org/10.1016/j.jbc.2021.100495
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
The spatial organization of RNA within cells is a crucial factor in a wide range of biological functions, spanning all kingdoms of life. However, a general understanding of RNA localization has been hindered by a lack of simple, high-throughput metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139aaa5ec3029eefd2204c214b254ce1
https://doi.org/10.7554/elife.29224
https://doi.org/10.7554/elife.29224
Autor:
Kendell Clement, Andreas Gnirke, Alexander M. Tsankov, J. Keith Joung, Christina Galonska, Casey A. Gifford, Julie Donaghey, Rahul Karnik, Shengdar Q. Tsai, William Mallard, Veronika Akopian, John L. Rinn, Ramona Pop, Jing Liao, Michael J. Ziller, Hongcang Gu, Alexander Meissner, Deepak Reyon
Publikováno v:
Nature Genetics. 47:469-478
DNA methylation is a key epigenetic modification involved in regulating gene expression and maintaining genomic integrity. Here we inactivated all three catalytically active DNA methyltransferases (DNMTs) in human embryonic stem cells (ESCs) using CR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e2b3d4662eb86e213f958cca3f3f2e
https://doi.org/10.1038/ng.3258
https://doi.org/10.1038/ng.3258
Autor:
Kelinda Tucker, Raju Kucherlapati, Ng Sam, John N. Weinstein, Lori Boice, Satish K. Tickoo, Saianand Balu, John C. Cheville, B. Arman Aksoy, Chip Stewart, Preethi H. Gunaratne, Martin L. Ferguson, Bogdan Czerniak, Christie Kovar, Theodore C. Goldstein, Mark E. Sherman, Juan M. Mosquera, Chris Sander, Yaron S.N. Butterfield, Leigh Anne Zach, Yiling Lu, Chandra Lebovitz, Gary Witkin, David Pot, Gordon Robertson, Richard A. Gibbs, James J. Hsieh, Benjamin P. Berman, Doug Voet, Kyle Chang, W. Marston Linehan, Margaret Morgan, Joan Pontius, Jodi Harr, Lihua Zhou, Joel S. Parker, David Van Den Berg, Michael B. Atkins, Sheila Reynolds, Petar Stojanov, Joel B. Nelson, Gordon B. Mills, Toni K. Choueiri, Weimin Xiao, Hye Jung E. Chun, Ronglai Shen, Rebecca Carlsen, Jennifer Brown, Tod D. Casasent, Sabina Signoretti, Jo Ellen Weaver, Phillip H. Lai, Dominique L. Berton, Patrick Plettner, Irina Ostrovnaya, Lisle E. Mose, Leslie Cope, Nils Gehlenborg, Heidi J. Sofia, Peter J. Park, Scott Morris, Hsin-Ta Wu, Fabio Vandin, Ranabir Guin, Daniel E. Carlin, Jacqueline E. Schein, Xi Liu, Nils Weinhold, Wandaliz Torres-Garcia, Cureline Olga Potapova, Daniel DiCara, Juok Cho, Steve Schumacher, Chris Wakefield, A. Rose Brannon, Susan M. Benton, Tom Bodenheimer, J. Todd Auman, Brenda Rabeno, Sharon M. Gorski, Eric E. Snyder, Divya Kalra, Brenda Ayala, Jiashan Zhang, Zhang Wei, Kyle Ellrott, Zhining Wang, Stacey Gabriel, Dominik Stoll, Daniel L. Rubin, W. Kimryn Rathmell, Eric Chuah, David Mallery, Tanja Davidsen, David Cogdell, Anders Jacobsen, John A. Demchok, Robert C. Onofrio, Anna Chu, Piotr A. Mieczkowski, Zhiyong Ding, Erin Curley, Johanna Gardner, Robert Worrell, Hailei Zhang, Jennifer C. Fisher, Donna M. Muzny, Rajiv Dhir, Walker Hale, Ari B. Kahn, Sheila Fisher, Giovanni Ciriello, Ken Burnett, Marco A. Marra, Wiam Bshara, Anil V. Parwani, Joshua M. Stuart, Richard Varhol, Kristin G. Ardlie, Han Yi, Lisa R. Trevino, Roy Tarnuzzer, Michael S. Noble, Erin Pleasance, Jesse Walsh, Leigh B. Thorne, Andy Chu, Peter W. Laird, Andrew J. Mungall, Rashmi N. Sanbhadti, Mark Backus, David A. Wheeler, Bradley A. Ozenberger, Jodi K. Maranchie, William Mallard, Jared R. Slobodan, Christine Czerwinski, Jireh Santibanez, Andrew J. Stout, Donghui Tan, Laura S. Schmidt, Junyuan Wu, Jianjiong Gao, Daniel J. Weisenberger, D. Neil Hayes, Scott Frazer, Alan P. Hoyle, Konstantin V. Fedosenko, Rehan Akbani, Todd Pihl, Rahul Vegesna, Lynda Chin, Shelley Alonso, Jeffrey G. Reid, Donna Morton, Cathy D. Vocke, R. Houston Thompson, Christopher C. Benz, Kenna R. Mills Shaw, Liming Yang, Carmelo Gaudioso, Nianxiang Zhang, Caleb F. Davis, Carrie Hirst, Shi Yan, Michael L. Blute, Barry S. Taylor, Mathew G. Soloway, Nina Thiessen, Paul T. Spellman, Deepak Srinivasan, Yongjun Zhao, Boris Reva, Wang Min, Stuart R. Jefferys, Benjamin J. Raphael, Nicholas J. Petrelli, Arash Shafiei, Lora Lewis, Eric Jonasch, David I. Heiman, Scot Waring, Richard A. Moore, Eric S. Lander, Evan O. Paull, Hoon Kim, Janae V. Simons, Stephen B. Baylin, Gad Getz, Stanley Girshik, Victor E. Reuter, Benjamin Gross, Ethan Cerami, Andrew D. Cherniack, Christine I. Smith, Christina Yau, Michael D. Topal, Peter Waltman, Jeff Boyd, Rameen Beroukhim, Angela Tam, Yingchun Liu, Peter A. Kigonya, Miruna Balasundaram, Maria J. Merino, David Haussler, Dinh Huyen, Elizabeth Buda, Michael S. Lawrence, Lin Pei, Charles M. Perou, Timothy J. Triche, Jessica Walton, Greg Eley, Tiffany Ting Liu, Joseph Paulauskis, Matthew Meyerson, Marc Ladanyi, Jaegil Kim, Katherine A. Hoadley, Huang Mei, Ilya Shmulevich, Robin J.N. Coope, Mary Iacocca, Natasja Wye, Adrian Ally, Mark A. Rubin, A. Ari Hakimi, Lori Huelsenbeck-Dill, Steven J.M. Jones, James Peterson, Mark A. Jensen, Barbara Tabak, Andrey Sivachenko, Julie Bergsten, John Eckman, Inanc Birol, Rohini Raman, Nipun Kakkar, Christina Liquori, Rileen Sinha, Dennis T. Maglinte, Lichtenstein Lee, Haiyan I. Li, William G. Kaelin, Anna K. Unruh, Noreen Dhalla, Candace Shelton, Roel G.W. Verhaak, Christopher J. Ricketts, Carrie Sougnez, Harsha Doddapaneni, Mark S. Guyer, Robert Penny, Michael F. Berger, Margi Sheth, Darlene Lee, Dimitra Tsavachidou, Chad J. Creighton, Prachi Kothiyal, Scott L. Carter, Michael Mayo, Zhu Jing, Kenneth Aldape, Corbin D. Jones, Moiz S. Bootwalla, Payal Sipahimalani, Martin Hirst, Sean P. Barletta, Kristian Cibulskis, Jerome Myers, Matthew C. Nicholls, Yidi J. Turman, Julien Baboud, Jeff Gentry, Carl Morrison, Gordon Saksena, Troy Shelton, Swapna Mahurkar, Robert A. Holt, Robert Sfeir, Shen Hui, Suzanne S. Fei, Christopher G. Wood, Candace Carter, S. Onur Sumer, Pheroze Tamboli, Yiming Zhu
Publikováno v:
Nature
Genetic changes underlying clear cell renal cell carcinoma (ccRCC) include alterations in genes controlling cellular oxygen sensing (for example, VHL) and the maintenance of chromatin states (for example, PBRM1). We surveyed more than 400 tumours usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caead79b1df1ac3484243872860a202f
http://europepmc.org/articles/PMC3771322
http://europepmc.org/articles/PMC3771322