Zobrazeno 1 - 10
of 30
pro vyhledávání: '"William Mallard"'
Autor:
Jordan P. Lewandowski, James C. Lee, Taeyoung Hwang, Hongjae Sunwoo, Jill M. Goldstein, Abigail F. Groff, Nydia P. Chang, William Mallard, Adam Williams, Jorge Henao-Meija, Richard A. Flavell, Jeannie T. Lee, Chiara Gerhardinger, Amy J. Wagers, John L. Rinn
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
LncRNA loci potentially contain multiple modes that can exert function, including DNA regulatory elements. Here, the authors generated genetic models in mice to dissect the role of the syntenically conserved lncRNA Firre in the context of hematopoies
Externí odkaz:
https://doaj.org/article/ae0f94d7e6434786ac485113730f81c4
Publikováno v:
eLife, Vol 6 (2017)
The spatial organization of RNA within cells is a crucial factor influencing a wide range of biological functions throughout all kingdoms of life. However, a general understanding of RNA localization has been hindered by a lack of simple, high-throug
Externí odkaz:
https://doaj.org/article/87937a28b4ce4872b428be61b44e7ef8
Autor:
Martin Sauvageau, Loyal A Goff, Simona Lodato, Boyan Bonev, Abigail F Groff, Chiara Gerhardinger, Diana B Sanchez-Gomez, Ezgi Hacisuleyman, Eric Li, Matthew Spence, Stephen C Liapis, William Mallard, Michael Morse, Mavis R Swerdel, Michael F D’Ecclessis, Jennifer C Moore, Venus Lai, Guochun Gong, George D Yancopoulos, David Frendewey, Manolis Kellis, Ronald P Hart, David M Valenzuela, Paola Arlotta, John L Rinn
Publikováno v:
eLife, Vol 2 (2013)
Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs in various physiological cond
Externí odkaz:
https://doaj.org/article/5fdb35f4c02f45c69bc508db25a26cb3
Autor:
Leonard I. Zon, Roby Joehanes, Eirini Trompouki, Stephen J. Chanock, Alireza Ghamari, Min-Lee Yang, Song Yang, Seraj N. Grimes, Sierra Tseng, Michael Superdock, Daniel E. Bauer, Divya S. Vinjamur, Victoria Chan, Karen Hoi, Richard A. Young, Sonja Boatman, Teresa V. Bowman, Avik Choudhuri, Brian J. Abraham, John L. Rinn, Santhi K. Ganesh, Alan B. Cantor, Kian Hong Kock, Audrey Sporrij, Barbara Hummel, William Mallard, Paul S. Albert, Asher Lichtig, Yi Zhou, Satish K. Nandakumar, Shinichiro Takahashi, Martha L. Bulyk, Leandro M. Colli
Publikováno v:
Nature Genetics
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nat Genet
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nat Genet
Genome-wide association studies identify genomic variants associated with human traits and diseases. Most trait-associated variants are located within cell-type-specific enhancers, but the molecular mechanisms governing phenotypic variation are less
Autor:
Chiara Gerhardinger, Taeyoung Hwang, Richard A. Flavell, James Lee, Amy J. Wagers, Jordan P. Lewandowski, Adam Williams, Nydia Chang, Abigail F. Groff, Jeannie T. Lee, Jorge Henao-Meija, John L. Rinn, Jill M. Goldstein, William Mallard, Hongjae Sunwoo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
RNA has been classically known to play central roles in biology, including maintaining telomeres, protein synthesis, and in sex chromosome compensation. While thousands of long noncoding RNAs (lncRNAs) have been identified, attributing RNA-based role
Autor:
Wei-Jun Qian, Chang Siang Lim, Manoj K. Gupta, Hwee Hui Lau, John L. Rinn, Marina A. Gritsenko, Larry Sai Weng Loo, William Mallard, Nicholas Jackson, Linh Nguyen, Richard D. Smith, Rohit N. Kulkarni, Adrian Kee Keong Teo
Publikováno v:
The Journal of Biological Chemistry
Human embryonic stem cells are a type of pluripotent stem cells (hPSCs) that are used to investigate their differentiation into diverse mature cell types for molecular studies. The mechanisms underlying insulin receptor (IR)-mediated signaling in the
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
The spatial organization of RNA within cells is a crucial factor in a wide range of biological functions, spanning all kingdoms of life. However, a general understanding of RNA localization has been hindered by a lack of simple, high-throughput metho
Autor:
Kendell Clement, Andreas Gnirke, Alexander M. Tsankov, J. Keith Joung, Christina Galonska, Casey A. Gifford, Julie Donaghey, Rahul Karnik, Shengdar Q. Tsai, William Mallard, Veronika Akopian, John L. Rinn, Ramona Pop, Jing Liao, Michael J. Ziller, Hongcang Gu, Alexander Meissner, Deepak Reyon
Publikováno v:
Nature Genetics. 47:469-478
DNA methylation is a key epigenetic modification involved in regulating gene expression and maintaining genomic integrity. Here we inactivated all three catalytically active DNA methyltransferases (DNMTs) in human embryonic stem cells (ESCs) using CR
Autor:
Avik Choudhuri, Eirini Trompouki, Alan B. Cantor, Song Yang, Daniel E. Bauer, Victoria Chan, Brian J. Abraham, John L. Rinn, Teresa V. Bowman, Divya S. Vinjamur, Sonja Boatman, Santhi K. Ganesh, Alireza Ghamari, Kanen Hoi, Min-Lee Yang, Leandro M. Colli, William Mallard, Barbara Hummel, Leonard I. Zon, Richard A. Young, Satish K. Nandakumar, Stephen J. Chanock, Vijay G. Sankaran, Yi Zhou, Sinichiro Takahashi
Publikováno v:
Blood. 132:1277-1277
Single Nucleotide Polymorphisms (SNPs) identified through genome-wide association studies (GWAS) provide insight into the mechanism of human genetic diseases, and majority of functional GWAS mutations target genomic regulatory elements. During erythr