Zobrazeno 1 - 10
of 19
pro vyhledávání: '"William M. McDougall"'
Autor:
William M. McDougall, Jill M. Perreira, Hui-Fang Hung, Anastassiia Vertii, E. Xiaofei, Wendy Zimmerman, Timothy F. Kowalik, Stephen Doxsey, Abraham L. Brass
Publikováno v:
iScience, Vol 12, Iss , Pp 270-279 (2019)
Summary: Congenital microcephaly occurs in utero during Zika virus (ZIKV) infection. The single-gene disorder, Majewski osteodysplastic primordial dwarfism type II (MOPDII), also leads to microcephaly and is concomitant with a decrease in the centros
Externí odkaz:
https://doaj.org/article/eba13b36577349b9a0943ca9f94a2913
Autor:
George Savidis, William M. McDougall, Paul Meraner, Jill M. Perreira, Jocelyn M. Portmann, Gaia Trincucci, Sinu P. John, Aaron M. Aker, Nicholas Renzette, Douglas R. Robbins, Zhiru Guo, Sharone Green, Timothy F. Kowalik, Abraham L. Brass
Publikováno v:
Cell Reports, Vol 16, Iss 1, Pp 232-246 (2016)
The flaviviruses dengue virus (DENV) and Zika virus (ZIKV) are severe health threats with rapidly expanding ranges. To identify the host cell dependencies of DENV and ZIKV, we completed orthologous functional genomic screens using RNAi and CRISPR/Cas
Externí odkaz:
https://doaj.org/article/69f8be84e6a64743bebffa1e93abc54a
Autor:
Jill M. Perreira, Aaron M. Aker, George Savidis, Christopher R. Chin, William M. McDougall, Jocelyn M. Portmann, Paul Meraner, Miles C. Smith, Motiur Rahman, Richard E. Baker, Annick Gauthier, Michael Franti, Abraham L. Brass
Publikováno v:
Cell Reports, Vol 12, Iss 5, Pp 850-863 (2015)
Human rhinovirus (HRV) causes upper respiratory infections and asthma exacerbations. We screened multiple orthologous RNAi reagents and identified host proteins that modulate HRV replication. Here, we show that RNASEK, a transmembrane protein, was ne
Externí odkaz:
https://doaj.org/article/977d31dbe9f04844b4a20adacce40747
Autor:
Vignesh N. Hariharan, Minwook Shin, Ching-Wen Chang, Daniel O’Reilly, Annabelle Biscans, Ken Yamada, Zhiru Guo, Mohan Somasundaran, Qi Tang, Kathryn Monopoli, Pranathi Meda Krishnamurthy, Gitali Devi, Nicholas McHugh, David A. Cooper, Dimas Echeverria, John Cruz, Io Long Chan, Ping Liu, Sun-Young Lim, Jill McConnell, Satya Prakash Singh, Samuel Hildebrand, Jacquelyn Sousa, Sarah M. Davis, Zachary Kennedy, Chantal Ferguson, Bruno M. D. C. Godinho, Yann Thillier, Jillian Caiazzi, Socheata Ly, Manish Muhuri, Karen Kelly, Fiachra Humphries, Alyssa Cousineau, Krishna Mohan Parsi, Qi Li, Yang Wang, René Maehr, Guangping Gao, Dmitry Korkin, William M. McDougall, Robert W. Finberg, Katherine A. Fitzgerald, Jennifer P. Wang, Jonathan K. Watts, Anastasia Khvorova
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The continuous evolution of SARS-CoV-2 variants complicates efforts to combat the ongoing pandemic, underscoring the need for a dynamic platform for the rapid development of pan-viral variant therapeutics. Oligonucleotide therapeutics are enhancing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0f1d783ae555e3a623c669e036bb016
https://doi.org/10.1073/pnas.2219523120
https://doi.org/10.1073/pnas.2219523120
Autor:
Melanie H. Wong, Helen Yu, Daniel Gonik, Derek Hansen, Wesley I. Sundquist, Debi Jin, Anita Niedziela-Majka, Nikolai Novikov, William M. McDougall, Shekeba Ahmadyar, Albert Liclican, Jill M. Perreira, Andrew Mulato, George Stepan, Jennifer R. Zhang, Bing Lu, Magdeleine Hung, Giuseppe A. Papalia, Renee R. Ram, John O. Link, Kevin Chou, Abraham L. Brass, Eric E. Paoli, Stephen R. Yant, Jim Zheng, Eric Singer, Eric Hu, Tomas Cihlar, Schroeder Scott D, Tse Winston C
Publikováno v:
Nat Med
People living with HIV (PLWH) have expressed concern about the life-long burden and stigma associated with taking pills daily and can experience medication fatigue that might lead to suboptimal treatment adherence and the emergence of drug-resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283229e5414364737d5a0814370ed2fa
https://doi.org/10.1038/s41591-019-0560-x
https://doi.org/10.1038/s41591-019-0560-x
Autor:
Rachel M. Gerstein, Patrizia Caposio, Gary C. Chan, Jill M. Perreira, Ronghua ZhuGe, Timothy F. Kowalik, Paul Meraner, Andrew D. Yurochko, Abraham L. Brass, Xiaofei E, William M. McDougall, Aaron M. Aker, Ping Lu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Identifying cell-surface receptors required for viral infection is important for developing antiviral therapies and effective vaccines. Human cytomegalovirus (HCMV) infects epithelial cells during interhost transmission. The pentameric p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17eda7aeda16760e9d96fb80ab538609
https://doi.org/10.1073/pnas.1814850116
https://doi.org/10.1073/pnas.1814850116
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2142
The discovery and implementation of CRISPR/Cas9 tools in pooled genetic screens have allowed for the rapid, high-fidelity identification of host-virus interactions. However, pooled CRISPR screening has significant limitations in its ability both to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0bc13549be0c08e342d364d388fd652c
https://pubmed.ncbi.nlm.nih.gov/32367370
https://pubmed.ncbi.nlm.nih.gov/32367370
Publikováno v:
Methods in Molecular Biology ISBN: 9781071605806
The discovery and implementation of CRISPR/Cas9 tools in pooled genetic screens have allowed for the rapid, high-fidelity identification of host-virus interactions. However, pooled CRISPR screening has significant limitations in its ability both to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e65f613ff79b76587a1177fc3bb1ffc1
https://doi.org/10.1007/978-1-0716-0581-3_17
https://doi.org/10.1007/978-1-0716-0581-3_17
Autor:
Sinu P. John, William M. McDougall, Jocelyn M. Portmann, Abraham L. Brass, Sharone Green, Jill M. Perreira, George Savidis, Zhiru Guo, Paul Meraner, Douglas Robbins, Gaia Trincucci, Timothy F. Kowalik, Aaron M. Aker, Nicholas Renzette
Publikováno v:
Cell Reports, Vol 16, Iss 1, Pp 232-246 (2016)
SummaryThe flaviviruses dengue virus (DENV) and Zika virus (ZIKV) are severe health threats with rapidly expanding ranges. To identify the host cell dependencies of DENV and ZIKV, we completed orthologous functional genomic screens using RNAi and CRI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32995d9e1159ee53186b9e365b57fbc3
https://doi.org/10.1016/j.celrep.2016.06.028
https://doi.org/10.1016/j.celrep.2016.06.028
Autor:
Anastassiia Vertii, William M. McDougall, Xiaofei E, Wendy Zimmerman, Hui-Fang Hung, Abraham L. Brass, Stephen J. Doxsey, Timothy F. Kowalik, Jill M. Perreira
Publikováno v:
iScience
iScience, Vol 12, Iss, Pp 270-279 (2019)
iScience, Vol 12, Iss, Pp 270-279 (2019)
Summary Congenital microcephaly occurs in utero during Zika virus (ZIKV) infection. The single-gene disorder, Majewski osteodysplastic primordial dwarfism type II (MOPDII), also leads to microcephaly and is concomitant with a decrease in the centroso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f77275122da58f14ca75deab77935ce
https://pubmed.ncbi.nlm.nih.gov/30716700
https://pubmed.ncbi.nlm.nih.gov/30716700