Výsledky vyhledávání - "William M. Mackin"

PGG-Glucan, a soluble β-(1,3)-glucan, enhances the oxidative burst response, microbicidal activity, and activates an NF-κB-like factor in human PMN: Evidence for a glycosphingolipid β-(1,3)-glucan receptor

Autor: Deborah Brunke-Reese, William M. Mackin, David S. Adams, Johanna Lindermuth, Janet W. Zimmerman, Robin S. Nathans, Jeffrey C. Tufts, Leslie Fisette, Eric Wakshull, John J. Crowley

Publikováno v: Immunopharmacology. 41:89-107

PGG-Glucan, a soluble beta-(1,6)-branched beta-(1,3)-linked glucose homopolymer derived from the cell wall of the yeast Saccharomyces cerevisiae, is an immunomodulator which enhances leukocyte anti-infective activity and enhances myeloid and megakary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b5bbd3052d2247b2db1d9b33ecaf77
https://doi.org/10.1016/s0162-3109(98)00059-9

Zobrazit plný text záznamu

Persistent Cardioprotection by Azapropazone in a Canine Model of Coronary Artery Thrombosis and Thrombolysis

Autor: George A. Boswell, Andrew W. Leamy, Pieter B.M.W.M. Timmermans, Martin J.M.C. Thoolen, Denver P. Fernando, Dolores E. Rasbach, William M. Mackin, Robert M. Knabb

Publikováno v: Journal of Cardiovascular Pharmacology. 17:390-396

Activated neutrophils and possibly xanthine oxidase-derived free radicals are believed to be mediators of ischemia and reperfusion-induced myocardial damage. We studied the cardioprotective effect of the neutrophil stabilizer and xanthine oxidase inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0183baf98e56a5eef504ff05056fc443
https://doi.org/10.1097/00005344-199103000-00006

Zobrazit plný text záznamu

Cellular and Biochemical Characterization of the Anti-Inflammatory Effects of DuP 654 in the Arachidonic Acid Murine Skin Inflammation Model (Part 2 of 2)

Autor: Richard R. Harris, William M. Mackin, Douglas G. Bait, Suzanne M. Rakich, Robert J. Collins, Elaine M. Bruin, Neil R. Ackerman

Publikováno v: Skin Pharmacology and Physiology. 3:35-40

The possible utility of DuP 654, a potent 5-lipoxygenase inhibitor, for treating human inflammatory skin disease was investigated in murine skin treated with 1.0 mg arachidonic acid (AA). When DuP 654 was applied to murine skin treated with AA, it in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b8c948fe6338c3916b1fe81519419b2
https://doi.org/10.1159/000316427

Zobrazit plný text záznamu

Activation of rat macrophages by Betafectin PGG-glucan requires cross-linking of membrane receptors distinct from complement receptor three (CR3)

Autor: William M. Mackin, Michael T Michalek, Kristen Lemerise, William Galbraith, David Melican, Myra L. Patchen, Matthew Langevin, Deborah Brunke-Reese

Publikováno v: Journal of leukocyte biology. 64(3)

PGG-glucan (Betafectin ) is a soluble, highly purified yeast (1,3)-β-glucan with broad anti-infective and immunomodulatory activities. These studies evaluated the ability of PGG-glucan to directly elicit O2– and tumor necrosis factor α (TNF-α) p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01641e123b518b14b006ca619ce3a8d
https://pubmed.ncbi.nlm.nih.gov/9738660

Zobrazit plný text záznamu

PGG-Glucan activates NF-kappaB-like and NF-IL-6-like transcription factor complexes in a murine monocytic cell line

Autor: William M. Mackin, J B Petro, David S. Adams, Robin S. Nathans, S C Pero, Eric Wakshull

Publikováno v: Journal of leukocyte biology. 62(6)

PGG-Glucan (Betafectin®) is a novel soluble β-glucan immunomodulator that enhances leukocyte microbicidal activities without inducing inflammatory cytokines. Although several different receptors for soluble and particulate β-glucans have been desc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313620e0c0916cfe45e95cafff1a2fce
https://pubmed.ncbi.nlm.nih.gov/9400829

Zobrazit plný text záznamu

The formylpeptide chemotactic receptor on rabbit peritoneal neutrophils: Change of receptor affinity and number by L-1-tosylamide-2-phenylethyl chloromethyl ketone (TPCK)

Autor: William M. Mackin, Elmer L. Becker

Publikováno v: International Journal of Immunopharmacology. 5:365-375

Pretreatment of rabbit peritoneal neutrophils at 37 degrees with 10-35 microM L-1-tosylamide-2-phenylethyl chloromethyl ketone (TPCK) decreases by 20-50% the detectable number of f Met-Leu-[3H]Phe binding sites. Greater TPCK concentrations, between 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a0174f3b82af454536f46073452a19
https://doi.org/10.1016/0192-0561(83)90011-5

Zobrazit plný text záznamu

Inhibition of rat neutrophil functional responses by azapropazone, an anti-gout drug

Autor: Connie L. Marshall, Suzanne M. Rakich, William M. Mackin

Publikováno v: Biochemical Pharmacology. 35:917-922

Azapropazone at concentrations of 0.1 to 1 mM inhibited by 30–70% rat neutrophil migration, aggregation, and degranulation in response to the synthetic chemotactic peptide fMet-Leu-Phe. Binding studies using fNle-Leu-[ 3 H]Phe, a radiolabeled analo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7b49af71e959062cc194df0adfa471
https://doi.org/10.1016/0006-2952(86)90077-8

Zobrazit plný text záznamu

Effect of azapropazone and allopurinol on myocardial infarct size in rats

Autor: Pieter B.M.W.M. Timmermans, Stephanie G. Montor, Martin J.M.C. Thoolen, William M. Mackin

Publikováno v: European Journal of Pharmacology. 140:203-207

The effect of the xanthine oxidase inhibitor allopurinol and the non-steroidal antiinflammatory agent azapropazone on infarct size in rats, subjected to 48 h of occlusion of the left anterior descending coronary artery, were studied. Allopurinol (50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ddc8aeb20b852dbb8f8f77b43e147c
https://doi.org/10.1016/0014-2999(87)90806-5

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání