Zobrazeno 1 - 3
of 3
pro vyhledávání: '"William M. Kohlbrenner"'
Autor:
J Song, Xiaoyu Lin, William M. Kohlbrenner, S W Fesik, Rongqi Wang, X Zhao, Leiming Li, Y Shen, Denise Wilcox
Publikováno v:
Gene Therapy
Delivering small interfering RNA (siRNA) to tumors using clinically viable formulations remains the primary technical hurdle that prevents the development of siRNA therapy for cancer treatment. Over the past several years, significant effort has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99057d1f59b6c4f13bb81b9216377f94
http://europepmc.org/articles/PMC3389750
http://europepmc.org/articles/PMC3389750
Autor:
Carol K. Wada, Prasad A. Dande, Xiaoyu Lin, William M. Kohlbrenner, Lu Tian, Stephen W. Fesik, Robert D. Hubbard, Xiaoli Huang, Denise Wilcox, Aparna Sarthy, Xiaobin Zhao, Yu Shen, Leiming Li, Todd M. Hansen, Rongqi Wang
Publikováno v:
Molecular cancer therapeutics. 12(11)
Successful siRNA therapeutics requires the optimal integration of multiple components, including an efficient delivery system, a disease indication that is appropriate for siRNA-based therapy, and a potent and nontoxic siRNA against a robust therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1647f0ff3b28b4c98dc6cc08c8fb8df7
https://pubmed.ncbi.nlm.nih.gov/23943805
https://pubmed.ncbi.nlm.nih.gov/23943805
Autor:
Liqing Chen, Wlodek Mandecki, Cele Abad-Zapatero, Janusz M. Sowadski, Sean M. Bell, William M. Kohlbrenner, David J. Neidhart
Publikováno v:
"Protein Engineering, Design and Selection". 5:605-610
Mutagenesis of the absolutely conserved residue Asp101 of the non-specific monoesterase alkaline phosphatase (E.C. 3.1.3.1) from E. coli has produced an enzyme with increased kcat. The carboxyl group of the Asp101 residue has been proposed to be invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f432ded1be924b776cbaa458caa61fe
https://doi.org/10.1093/protein/5.7.605
https://doi.org/10.1093/protein/5.7.605