Zobrazeno 1 - 10
of 55
pro vyhledávání: '"William M. Johnson"'
Publikováno v:
Nutrients, Vol 4, Iss 10, Pp 1399-1440 (2012)
Dysregulation of glutathione homeostasis and alterations in glutathione-dependent enzyme activities are increasingly implicated in the induction and progression of neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Huntington’s
Externí odkaz:
https://doaj.org/article/ab6251809d724412aedd18a0a68247df
Autor:
W. Daniel Stamer, Michael A. Hauser, Guorong Li, William M. Johnson, Maria Gomez-Caraballo, Jenny Cui, Todd L. Fleming, Iris Navarro, Heather Schmitt, Chanyoung Lee, C. Ross Ethier, Sina Farsiu, Joseph M. Sherwood, Michael H. Elliott
Publikováno v:
FASEB J
Lysyl oxidase like-1 (LOXL1), a vital crosslinking enzyme in elastin fiber maintenance, is essential for the stability and strength of elastic vessels and tissues. Variants in the LOXL1 locus associate with a dramatic increase in risk of exfoliation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3aab10077a3ece4b0c661c8d33806d9
https://doi.org/10.1096/fj.202000702rr
https://doi.org/10.1096/fj.202000702rr
Autor:
Aaron S. Wise, Min Hyung Kang, Neena Singh, Ajay Ashok, Douglas J Rhee, Padmanabhan P. Pattabiraman, William M. Johnson, Ranjana Ravikumar, Michael Lonigro
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Endothelial-to-mesenchyme-like transition (Endo-MT) of trabecular meshwork (TM) cells is known to be associated with primary open angle glaucoma (POAG). Here, we investigated whether the prion protein (PrPC), a neuronal protein known to modulate epit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7640795358c31d51b0bcd82f2014662
http://link.springer.com/article/10.1038/s41598-019-49482-6
http://link.springer.com/article/10.1038/s41598-019-49482-6
Autor:
Sabrina Liu, Hongmei Mu, Jingwen Cai, Inas F. Aboobakar, W. Daniel Stamer, Kristin Perkumas, Yutao Liu, Inas Helwa, Hannah Youngblood, Hongfang Yu, William M. Johnson, Yanzhong Hu, Eric Hu, Michelle Drewry
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Intraocular pressure (IOP), the primary risk factor for primary open-angle glaucoma, is determined by resistance to aqueous outflow through the trabecular meshwork (TM). IOP homeostasis relies on TM responses to mechanical stretch. To model t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e4779ebd56b64169098946544167f8
http://europepmc.org/articles/PMC7405621
http://europepmc.org/articles/PMC7405621
Autor:
Nikolai P. Skiba, Michael A. Hauser, R. Rand Allingham, W. Daniel Stamer, Laura K. Finnegan, Inas F. Aboobakar, Maria Gomez-Caraballo, Heather Schmitt, William M. Johnson, David L. Corcoran, Megan Parker, Shelby Strickland
Publikováno v:
Hum Mol Genet
Individuals with pseudoexfoliation (PEX) syndrome exhibit various connective tissue pathologies associated with dysregulated extracellular matrix homeostasis. PEX glaucoma is a common, aggressive form of open-angle glaucoma resulting from the deposit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5289e6270c28a6b63754989bfdc1d316
https://europepmc.org/articles/PMC7390937/
https://europepmc.org/articles/PMC7390937/
Motor and non-motor features of Parkinson's disease in LRRK2 G2019S carriers versus matched controls
Autor:
John J. Mieyal, William M. Johnson, Shu G. Chen, David E. Riley, I. Jung Feng, Ellen M. Walter, Curtis Tatsuoka, Harry Owusu-Dapaah, Christina M. Whitney, Steven A. Gunzler, Amy L. Wilson-Delfosse, Shivam Om Mittal
Publikováno v:
Journal of the Neurological Sciences. 388:203-207
Introduction LRRK2 G2019S mutation carriers with Parkinson's disease (PD) have been generally indistinguishable from those with idiopathic PD, with the exception of variable differences in some motor and non-motor domains, including cognition, gait,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41670c4c344a2b87b4019a9067ffd4d1
https://doi.org/10.1016/j.jns.2018.03.025
https://doi.org/10.1016/j.jns.2018.03.025
Autor:
Amy L. Wilson-Delfosse, Shu G. Chen, Nicole M. Milkovic, John J. Mieyal, Mark A. Wilson, Pierce L. Curran, Kyonghwan Choe, Chen Yao, Ajit Ray, Olga Gorelenkova Miller, Vijayalakshmi Ravindranath, Marcin Golczak, Wenzhang Wang, William M. Johnson, Xiongwei Zhu, Jiusheng Lin
Publikováno v:
Biochemistry. 55:4519-4532
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, caused by the degeneration of the dopaminergic neurons in the substantia nigra. Mutations in PARK7 (DJ-1) result in early onset autosomal recessive PD, and oxidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ddb03c05403e95c7125fa3aa11383f
https://doi.org/10.1021/acs.biochem.5b01132
https://doi.org/10.1021/acs.biochem.5b01132
Autor:
Richard E. Zigmond, Alicia DeFrancesco-Lisowitz, Janna Kiselar, Jennifer M. Pilat, Vera Y. Moiseenkova-Bell, William M. Johnson, Matthew R. Cohen
Publikováno v:
Molecular and Cellular Biology. 35:4238-4252
Neurite outgrowth is key to the formation of functional circuits during neuronal development. Neurotrophins, including nerve growth factor (NGF), increase neurite outgrowth in part by altering the function and expression of Ca(2+)-permeable cation ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456df3fbc75c16c0a2a0dc8638cc94b6
https://doi.org/10.1128/mcb.00549-15
https://doi.org/10.1128/mcb.00549-15
Publikováno v:
The Journal of family practice. 67(10)
Several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ced0a65eff75a585a4bd440e61443892
https://pubmed.ncbi.nlm.nih.gov/30422999
https://pubmed.ncbi.nlm.nih.gov/30422999
Autor:
Inas Helwa, Jingwen Cai, W. D. Stamer, Mu H, Liu S, Drewry, Hu E, Yutao Liu, William M. Johnson, Yanzhong Hu, Pedro Gonzalez
PurposeRegulation of intraocular pressure is dependent upon homeostatic responses of trabecular meshwork (TM) cells to mechanical stretch. Despite the important roles of miRNAs in regulating TM function and aqueous outflow, it remains unclear how miR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ad60a31b392623f26b3e9a92e1f98b
https://doi.org/10.1101/406082
https://doi.org/10.1101/406082