Zobrazeno 1 - 10
of 344
pro vyhledávání: '"William M. Grady"'
Autor:
Elizabeth S. Nakasone, Tyler J. Zemla, Ming Yu, She Yu Lin, Fang-Shu Ou, Kelly Carter, Federico Innocenti, Leonard Saltz, William M. Grady, Stacey A. Cohen
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTWhile epigenomic alterations are common in colorectal cancers (CRC), few epigenomic biomarkers that risk-stratify patients have been identified. We thus sought to determine the potential of ZNF331 promoter hypermethylation (mZNF331) as a prog
Externí odkaz:
https://doaj.org/article/9934e8c678554cc0aff190ec4294bfc1
Autor:
Zixu Yuan, Wenle Chen, Duo Liu, Qiyuan Qin, William M. Grady, Alessandro Fichera, Huaiming Wang, Ting Hou, Xinze Lv, Chanhe Li, Hui Wang, Jian Cai
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background The detection of peritoneal metastasis (PM) is limited by current imaging tools. In this prospective study, we aimed to evaluate the sensitivity and specificity of peritoneal cell-free DNA (cfDNA) for diagnosis of PM. Methods Colo
Externí odkaz:
https://doaj.org/article/804e5061764f467a96751f023173b084
Autor:
Lynn Symonds, Ming Yu, YuHong Zhang, Fang-Shu Ou, Tyler J. Zemla, Kelly Carter, Monica Bertagnolli, Federico Innocenti, Linda JW Bosch, Gerrit A Meijer, Beatriz Carvalho, William M. Grady, Stacey A. Cohen
Publikováno v:
Epigenetics, Vol 17, Iss 12, Pp 1715-1725 (2022)
Aberrantly methylated genes contribute to the landscape of epigenetic alterations in colorectal adenocarcinoma. The global CpG Island methylator phenotype (CIMP) and individually methylated genes are potential prognostic/predictive biomarkers. Resear
Externí odkaz:
https://doaj.org/article/fedc615c145b49aa9716d591e2847ecb
Autor:
Catherine Duggan, Ming Yu, Amber R. Willbanks, Jean de Dieu Tapsoba, Ching-Yun Wang, William M. Grady, Anne McTiernan
Publikováno v:
Epigenetics, Vol 17, Iss 10, Pp 1070-1079 (2022)
Physical activity reduces risk of colon cancer by 20–30%. Aberrant methylation patterns are common epigenetic alterations in colorectal adenomas, and cancers and play a role in cancer initiation and progression. Alterations identified in normal col
Externí odkaz:
https://doaj.org/article/fd3320901d044f349c481bb8eed2e6f2
Autor:
Zixu Yuan, Xihu Yu, Wenle Chen, Daici Chen, Jian Cai, Yingming Jiang, Xiaoxia Liu, Zhijie Wu, Lei Wang, William M. Grady, Hui Wang
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract Background The screening biomarkers for early detection of colorectal cancer (CRC) is lacking. The aim is to identify epigenetic silenced genes and clarify its roles and underlying mechanism in CRC. We conducted integrative analyses of epige
Externí odkaz:
https://doaj.org/article/2616435b98904b0ebbc866de67484ed4
Autor:
Zixu Yuan, Xihu Yu, Wenle Chen, Daici Chen, Jian Cai, Yingming Jiang, Xiaoxia Liu, Zhijie Wu, Lei Wang, William M. Grady, Hui Wang
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c03a9c4042f14fc483e948b7b72388eb
Autor:
Caroline Himbert, Jane C. Figueiredo, David Shibata, Jennifer Ose, Tengda Lin, Lyen C. Huang, Anita R. Peoples, Courtney L. Scaife, Bartley Pickron, Laura Lambert, Jessica N. Cohan, Mary Bronner, Seth Felder, Julian Sanchez, Sophie Dessureault, Domenico Coppola, David M. Hoffman, Yosef F. Nasseri, Robert W. Decker, Karen Zaghiyan, Zuri A. Murrell, Andrew Hendifar, Jun Gong, Eiman Firoozmand, Alexandra Gangi, Beth A. Moore, Kyle G. Cologne, Maryliza S. El-Masry, Nathan Hinkle, Justin Monroe, Matthew Mutch, Cory Bernadt, Deyali Chatterjee, Mika Sinanan, Stacey A. Cohen, Ulrike Wallin, William M. Grady, Paul D. Lampe, Deepti Reddi, Mukta Krane, Alessandro Fichera, Ravi Moonka, Esther Herpel, Peter Schirmacher, Matthias Kloor, Magnus von Knebel-Doeberitz, Johanna Nattenmueller, Hans-Ulrich Kauczor, Eric Swanson, Jolanta Jedrzkiewicz, Stephanie L. Schmit, Biljana Gigic, Alexis B. Ulrich, Adetunji T. Toriola, Erin M. Siegel, Christopher I. Li, Cornelia M. Ulrich, Sheetal Hardikar
Publikováno v:
Cancers, Vol 13, Iss 15, p 3817 (2021)
Early-onset colorectal cancer has been on the rise in Western populations. Here, we compare patient characteristics between those with early- (n = 2193). We calculated descriptive statistics and assessed associations of clinicodemographic factors wit
Externí odkaz:
https://doaj.org/article/d342194024f14ff59e40e69c8e8a263b
Autor:
E. Georg Luebeck, Kit Curtius, William D. Hazelton, Sean Maden, Ming Yu, Prashanthi N. Thota, Deepa T. Patil, Amitabh Chak, Joseph E. Willis, William M. Grady
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-10 (2017)
Abstract Background Recent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that is called epigenetic drift. However, the evolving patterns, functional consequences, and dynamics of epi
Externí odkaz:
https://doaj.org/article/98577dabbc1e4e40b76e727b3863035f
Autor:
Stacey A. Cohen, Ming Yu, Kelsey Baker, Mary Redman, Chen Wu, Tai J. Heinzerling, Ralph M. Wirtz, Elpida Charalambous, George Pentheroudakis, Vassiliki Kotoula, Konstantine T. Kalogeras, George Fountzilas, William M. Grady
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-8 (2017)
Abstract Background The CpG island methylator phenotype (CIMP) in stage III colon cancer (CRC) has been associated with improved survival after treatment with adjuvant irinotecan-based chemotherapy. In this analysis, we determine whether CIMP status
Externí odkaz:
https://doaj.org/article/ce6a026baba1411ca058ebd7dc4f73cf
Autor:
Biljana Gigic, Johanna Nattenmüller, Martin Schneider, Yakup Kulu, Karen L. Syrjala, Jürgen Böhm, Petra Schrotz-King, Hermann Brenner, Graham A. Colditz, Jane C. Figueiredo, William M. Grady, Christopher I. Li, David Shibata, Erin M. Siegel, Adetunji T. Toriola, Hans-Ulrich Kauczor, Alexis Ulrich, Cornelia M. Ulrich
Publikováno v:
Nutrients, Vol 12, Iss 5, p 1247 (2020)
Background: Obesity, defined by body mass index (BMI), measured at colorectal cancer (CRC) diagnosis has been associated with postoperative complications and survival outcomes. However, BMI does not allow for a differentiation between fat and muscle
Externí odkaz:
https://doaj.org/article/0ca0fab67812488597778cd41aff61c1