Zobrazeno 1 - 10
of 51
pro vyhledávání: '"William M. Alexander"'
Publikováno v:
Proteomes, Vol 5, Iss 3, p 20 (2017)
Although not yet truly ‘comprehensive’, modern mass spectrometry-based experiments can generate quantitative data for a meaningful fraction of the human proteome. Importantly for large-scale protein expression analysis, robust data pipelines are
Externí odkaz:
https://doaj.org/article/a54a3fc2720f45279481ad8bd3ab8ff8
Autor:
Michael P. East, Tinghu Zhang, Gary Kruppa, Michael Krause, William M. Alexander, Sven Brehmer, He Zhu, Gary L. Johnson, Scott B. Ficarro, Guillaume Adelmant, Jens Decker, Jarrod A. Marto, Laura E Fleming, Nathanael S. Gray, Matthew Willetts
Publikováno v:
Anal Chem
Parallel reaction monitoring (PRM) has emerged as a popular approach for targeted protein quantification. With high ion utilization efficiency and first-in-class acquisition speed, the timsTOF Pro provides a powerful platform for PRM analysis. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977035bed66c3b3d3f7a5a0e2250c910
https://doi.org/10.1021/acs.analchem.1c02349
https://doi.org/10.1021/acs.analchem.1c02349
Autor:
Congcong Chen, Zhigang Wu, Jun Yin, Peng George Wang, Cheng Ma, William M. Alexander, Lang Ding, Shuaishuai Wang, Roni J. Bollag, Ding Liu, Lei Li, Yunpeng Liu, He Zhu, Kebin Liu
Publikováno v:
Anal Chem
Precise assignment of sialylation linkages at the glycopeptide level is of importance in bottom-up glycoproteomics and an indispensable step to understand the function of glycoproteins in pathogen-host interactions and cancer progression. Even though
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469733511925aafa1130ce5b4566fd66
https://pubmed.ncbi.nlm.nih.gov/32271005
https://pubmed.ncbi.nlm.nih.gov/32271005
A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification
Autor:
Baishan Jiang, Zainab M. Doctor, Jared L. Johnson, Lewis C. Cantley, Tomer M. Yaron, Tinghu Zhang, Jarrod A. Marto, William M. Alexander, Sindhu Carmen Sivakumaren, Charles J. Murphy, Scott B. Ficarro, Nathanael S. Gray, Nicholas Kwiatkowski, Christopher M. Browne, Joseph D. Card
Publikováno v:
Journal of the American Chemical Society. 141:191-203
Despite recent clinical successes for irreversible drugs, potential toxicities mediated by unpredictable modification of off-target cysteines represents a major hurdle for expansion of covalent drug programs. Understanding the proteome-wide binding p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b54ff682fc3884c846f37412aaa35c
https://doi.org/10.1021/jacs.8b07911
https://doi.org/10.1021/jacs.8b07911
Autor:
Nathanael S. Gray, Michael J. Eck, Randall McNally, Tinghu Zhang, Hyuk-Soo Seo, Jarrod A. Marto, William M. Alexander, Christopher M. Browne, Ilaria Lamberto, Sirano Dhe-Paganon, Eun Young Park, Joseph D. Card, Sara J. Buhrlage, Scott B. Ficarro
Publikováno v:
Analytical Chemistry. 88:12248-12254
The recent approval of covalent inhibitors for multiple clinical indications has reignited enthusiasm for this class of drugs. As interest in covalent drugs has increased, so too has the need for analytical platforms that can leverage their mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8c5497903772fb38883f16ea5f7e44
https://doi.org/10.1021/acs.analchem.6b03394
https://doi.org/10.1021/acs.analchem.6b03394
Autor:
William M. Alexander
Publikováno v:
Globalizing Feminist Bioethics ISBN: 9780429500176
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b02d3496e5df9016463bb69498498ea
https://doi.org/10.4324/9780429500176-13
https://doi.org/10.4324/9780429500176-13
Autor:
L. Mario Amzel, Yana Li, Antonieta L. Salguero, Zan Chen, William M. Alexander, Scott B. Ficarro, Daniel R. Dempsey, Albert Z. Liu, Nam Chu, Philip A. Cole, Sandra B. Gabelli, Jarrod A. Marto
Publikováno v:
Cell. 174(4)
Akt is a critical protein kinase that drives cancer proliferation, modulates metabolism, and is activated by C-terminal phosphorylation. The current structural model for Akt activation by C-terminal phosphorylation has centered on intramolecular inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d0d97043b58ce00e43bd8a03e0419b
https://pubmed.ncbi.nlm.nih.gov/30078705
https://pubmed.ncbi.nlm.nih.gov/30078705
Publikováno v:
Proteomes; Volume 5; Issue 3; Pages: 20
Proteomes
Proteomes, Vol 5, Iss 3, p 20 (2017)
Proteomes
Proteomes, Vol 5, Iss 3, p 20 (2017)
Although not yet truly ‘comprehensive’, modern mass spectrometry-based experiments can generate quantitative data for a meaningful fraction of the human proteome. Importantly for large-scale protein expression analysis, robust data pipelines are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6573fb746e088852bafef36043583886
Publikováno v:
Proteomics. 17(15-16)
The continued evolution of modern mass spectrometry instrumentation and associated methods represents a critical component in efforts to decipher the molecular mechanisms which underlie normal physiology and understand how dysregulation of biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d5c80ed547739a570c9351aa43a86b
https://pubmed.ncbi.nlm.nih.gov/28686798
https://pubmed.ncbi.nlm.nih.gov/28686798
Publikováno v:
PROTEOMICS. 17:1600437
Post-genomic studies continue to highlight the potential clinical importance of protein phosphorylation signaling pathways in drug discovery. Unfortunately the dynamic range and variable stoichiometry of protein phosphorylation continues to stymie ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686011a742e87e9228c866c49968811e
https://doi.org/10.1002/pmic.201600437
https://doi.org/10.1002/pmic.201600437