Zobrazeno 1 - 10
of 474
pro vyhledávání: '"William M. Gallagher"'
Autor:
Kate Connor, Emer Conroy, Kieron White, Liam P. Shiels, Simon Keek, Abdalla Ibrahim, William M. Gallagher, Kieron J. Sweeney, James Clerkin, David O’Brien, Jane B. Cryan, Philip J. O’Halloran, Josephine Heffernan, Francesca Brett, Philippe Lambin, Henry C. Woodruff, Annette T. Byrne
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Here, we establish a CT-radiomics based method for application in invasive, orthotopic rodent brain tumour models. Twenty four NOD/SCID mice were implanted with U87R-Luc2 GBM cells and longitudinally imaged via contrast enhanced (CE-CT) imag
Externí odkaz:
https://doaj.org/article/f5502ff7e06945ad8173541c1ee43f95
Autor:
Ian S. Miller, Sonja Khan, Liam P. Shiels, Sudipto Das, Alice C. O' Farrell, Kate Connor, Adam Lafferty, Bruce Moran, Claudio Isella, Paul Loadman, Emer Conroy, Susan Cohrs, Roger Schibli, Robert S. Kerbel, William M. Gallagher, Elisabetta Marangoni, Kathleen Bennett, Darran P. O' Connor, Róisín M. Dwyer, Annette T. Byrne
Publikováno v:
Cancer Medicine, Vol 11, Iss 20, Pp 3820-3836 (2022)
Abstract Backgorund Prior data suggest pre‐diagnostic aspirin use impacts breast tumour biology and patient outcome. Here, we employed faithful surgical resection models of HER2+ and triple‐negative breast cancer (TNBC), to study outcome and resp
Externí odkaz:
https://doaj.org/article/1f5177ae512441ffab056e955c214925
Autor:
Sara Wahlin, Karolina Boman, Bruce Moran, Björn Nodin, William M. Gallagher, Emelie Karnevi, Karin Jirström
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Background The response to neoadjuvant cisplatin-based chemotherapy (NAC) in muscle-invasive bladder cancer (MIBC) is impaired in up to 50% of patients due to chemoresistance, with no predictive biomarkers in clinical use. The proto-oncogene
Externí odkaz:
https://doaj.org/article/23e277afa0164cfbaae39771d287a33d
Autor:
Sofie Olsson Hau, Sara Wahlin, Sophie Cervin, Vilgot Falk, Björn Nodin, Jacob Elebro, Jakob Eberhard, Bruce Moran, William M Gallagher, Emelie Karnevi, Karin Jirström
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 1, Pp 65-77 (2022)
Abstract The outlook for patients with pancreatic cancer remains dismal. Treatment options are limited and chemotherapy remains standard of care, leading to only modest survival benefits. Hence, there is a great need to further explore the mechanisti
Externí odkaz:
https://doaj.org/article/636b8c745cbd42caa4d4e025acbae2fc
Autor:
Kayleigh Slater, Rosa Bosch, Kaelin Francis Smith, Chowdhury Arif Jahangir, Sandra Garcia-Mulero, Arman Rahman, Fiona O’Connell, Josep M. Piulats, Valerie O’Neill, Noel Horgan, Sarah E. Coupland, Jacintha O’Sullivan, William M. Gallagher, Alberto Villanueva, Breandán N. Kennedy
Publikováno v:
Frontiers in Medicine, Vol 9 (2023)
Uveal melanoma (UM) is an intraocular cancer with propensity for liver metastases. The median overall survival (OS) for metastatic UM (MUM) is 1.07 years, with a reported range of 0.84–1.34. In primary UM, high cysteinyl leukotriene receptor 1 (Cys
Externí odkaz:
https://doaj.org/article/eac8866d1abb4c86aceb6f7196a8a3cd
Autor:
Romina Silva, Bruce Moran, Niamh M. Russell, Ciara Fahey, Tatjana Vlajnic, Rustom P. Manecksha, Stephen P. Finn, Donal J. Brennan, William M. Gallagher, Antoinette S. Perry
Publikováno v:
Epigenetics, Vol 15, Iss 6-7, Pp 715-727 (2020)
Background: Liquid biopsies offer significant potential for informing on cancer progression and therapeutic resistance via minimally invasive serial monitoring of genetic alterations. Although the cancer epigenome is a central driving force in most n
Externí odkaz:
https://doaj.org/article/727a2332a3ba42f695de2da13e63a61a
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Accumulating evidence indicates that breakdown of the+ protective mucosal barrier of the gut plays a role in colorectal cancer (CRC) development. Inflammation and oxidative stress in the colonic epithelium are thought to be involved in colorectal car
Externí odkaz:
https://doaj.org/article/9144b2af44834073bbb3d7f37b18bf71
Autor:
Dominiek Smeets, Ian S. Miller, Darran P. O’Connor, Sudipto Das, Bruce Moran, Bram Boeckx, Timo Gaiser, Johannes Betge, Ana Barat, Rut Klinger, Nicole C. T. van Grieken, Chiara Cremolini, Hans Prenen, Massimiliano Mazzone, Jeroen Depreeuw, Orna Bacon, Bozena Fender, Joseph Brady, Bryan T. Hennessy, Deborah A. McNamara, Elaine Kay, Henk M. Verheul, Neerincx Maarten, William M. Gallagher, Verena Murphy, Jochen H. M. Prehn, Miriam Koopman, Cornelis J. A. Punt, Fotios Loupakis, Matthias P. A. Ebert, Bauke Ylstra, Diether Lambrechts, Annette T. Byrne
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Increased copy number alterations, indicative of chromosomal instability, is associated with poor cancer outcome. Here, metastatic colorectal cancer patients displaying intermediate-high CIN associate with improved outcome following chemotherapy and
Externí odkaz:
https://doaj.org/article/d17fc441244b44c587907023fe2c93dd
Autor:
Alex J Eustace, Neil T Conlon, Martina S J McDermott, Brigid C Browne, Patrick O’Leary, Frankie A Holmes, Virginia Espina, Lance A Liotta, Joyce O’Shaughnessy, Clair Gallagher, Lorraine O’Driscoll, Sweta Rani, Stephen F Madden, Neil A O’Brien, Charles Ginther, Dennis Slamon, Naomi Walsh, William M Gallagher, Radoslaw Zagozdzon, William R Watson, Norma O’Donovan, John Crown
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background Lapatinib has clinical efficacy in the treatment of trastuzumab-refractory HER2-positive breast cancer. However, a significant proportion of patients develop progressive disease due to acquired resistance to the drug. Induction of
Externí odkaz:
https://doaj.org/article/5de7181f330d45b98eeaa2bf7e64c819
Autor:
Jasper Wouters, Miguel Vizoso, Anna Martinez-Cardus, F. Javier Carmona, Olivier Govaere, Teresa Laguna, Jesuchristopher Joseph, Peter Dynoodt, Claudia Aura, Mona Foth, Roy Cloots, Karin van den Hurk, Balazs Balint, Ian G. Murphy, Enda W. McDermott, Kieran Sheahan, Karin Jirström, Bjorn Nodin, Girish Mallya-Udupi, Joost J. van den Oord, William M. Gallagher, Manel Esteller
Publikováno v:
BMC Medicine, Vol 15, Iss 1, Pp 1-16 (2017)
Abstract Background Cutaneous melanoma is the deadliest skin cancer, with an increasing incidence and mortality rate. Currently, staging of patients with primary melanoma is performed using histological biomarkers such as tumor thickness and ulcerati
Externí odkaz:
https://doaj.org/article/c8d582e4e15a4836ac917268c4fb77a8