Zobrazeno 1 - 10
of 10
pro vyhledávání: '"William M. Barker"'
Autor:
Damian G. Weaver, William M. Barker, Christopher T. Saeui, Karin Worm, Robert N. DeHaven, Joel A. Cassel, Doreen-Marie S. Dulay, Rosalyn C. Green, Bernice L. Brogdon, Christopher J. LaBuda, Gabriel J. Stabley, Steven A. Smith, Michael Koblish, Roland E. Dolle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5004-5008
Recently sulfamoyl benzamides were identified as a novel series of cannabinoid receptor ligands. Replacing the sulfonamide functionality and reversing the original carboxamide bond led to the discovery of N-(3-(morpholinomethyl)-phenyl)-amides as pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2d7cab39a1d9528a999f22400e8c9d
https://doi.org/10.1016/j.bmcl.2009.07.057
https://doi.org/10.1016/j.bmcl.2009.07.057
Autor:
Guo-Hua Chu, William M. Barker, Rolf T. Windh, Patrick J. Little, Michael J. Derelanko, Bertrand Le Bourdonnec, Michael Koblish, Diane L. DeHaven-Hudkins, Minghua Gu, Thomas M. Graczyk, Daniel D. Wiant, Lara K. Leister, Bernice L. Brogdon, Robert N. DeHaven, Christopher W. Ajello, Steven A. Smith, Serge Belanger, David D. Christ, Paul A. Tuthill, Steve Kutz, Joel A. Cassel, Marina S. Feschenko, Roland E. Dolle
Publikováno v:
Journal of Medicinal Chemistry. 51:5893-5896
Selective delta opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain conditions. A spirocyclic derivative was identified as a promising hit through screening. Subsequent lead optimization iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619e8cbfdd85472b2463e048206eebc5
https://doi.org/10.1021/jm8008986
https://doi.org/10.1021/jm8008986
Autor:
Roland E. Dolle, Diane L. DeHaven-Hudkins, Daniel D. Wiant, Joel A. Cassel, William M. Barker, Patrick J. Little, Bertrand Le Bourdonnec, Robert N. DeHaven, Serge Belanger, Nathalie Conway-James, Timothy J. O’Neill
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2006-2012
A series of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines, mu opioid receptor antagonists, analogs of alvimopan, were prepared using solid phase methodology. This study led to the identification of a highly selective mu opioid recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26c41c2d45b977ff06a701c18afedae
https://doi.org/10.1016/j.bmcl.2008.01.106
https://doi.org/10.1016/j.bmcl.2008.01.106
Publikováno v:
Journal of Combinatorial Chemistry. 8:132-140
The microwave-assisted solid-phase synthesis of piperazines, 3,9-diazaspiro[5.5]undecanes and 2,9-diazaspiro[5.5]undecanes is reported. The synthesis relies on the direct annulation of primary amines with resin-bound bismesylates 12, 17, and 22. Crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2d8966744b7da2881a7a751a694d1e
https://doi.org/10.1021/cc050106w
https://doi.org/10.1021/cc050106w
Autor:
Pamela R. Seida, William M. Barker, Calum Macleod, Torsten Herbertz, Roland E. Dolle, Blanca Martinez-Teipel
Publikováno v:
Angewandte Chemie. 117:5980-5983
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057a2ef80746c7f229fa1f1b6bb56dd7
https://doi.org/10.1002/ange.200501665
https://doi.org/10.1002/ange.200501665
Autor:
Serge Belanger, William M. Barker, Patrick J. Little, Pamela R. Seida, Roland E. Dolle, Paul A. Tuthill, Michael Koblish, Joel A. Cassel, Susan L. Gottshall, Robert N. DeHaven, Diane L. DeHaven-Hudkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5693-5697
A new class of kappa-opioid receptor agonists is described. The design of these agents was based upon energy minimization and structural overlay studies of the generic azepin-2-one structure 3 with the crystal structure of arylacetamide kappa agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a510b8869767016eef7e278505207c4
https://doi.org/10.1016/j.bmcl.2004.08.041
https://doi.org/10.1016/j.bmcl.2004.08.041
Autor:
Thomas M. Graczyk, Patrick J. Little, Diane L. DeHaven-Hudkins, William M. Barker, Michael Koblish, Rolf T. Windh, Minghua Gu, Marina S. Feschenko, Joel A. Cassel, Guo-Hua Chu, Daniel D. Wiant, Steve Kutz, Lara Kathryn Leister, Robert N. DeHaven, Serge Belanger, Bertrand Le Bourdonnec, Roland E. Dolle, Bernice L. Brogdon, Steven A. Smith, Tuthill Paul Anson, Michael J. Derelanko, Q. Jean Zhou, Christopher W. Ajello
Publikováno v:
Journal of medicinal chemistry. 52(18)
Selective, nonpeptidic delta opioid receptor agonists have been the subject of great interest as potential novel analgesic agents. The discoveries of BW373U86 (1) and SNC80 (2) contributed to the rapid expansion of research in this field. However, po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc53d00daff04ac1abedc34cfddc85c
https://pubmed.ncbi.nlm.nih.gov/19694468
https://pubmed.ncbi.nlm.nih.gov/19694468
Publikováno v:
Journal of chromatography. A. 1216(45)
Chiral recognition and resolution of methanobenzazocines was investigated by HPLC using polysaccharide, Pirkle-type, native and derivatized beta-cyclodextrin chiral stationary phases. Enantioseparation of phenyl substituted 2,6-methanobenzazocines wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed7297119cbc3141c07af3157c1716c
https://pubmed.ncbi.nlm.nih.gov/19801151
https://pubmed.ncbi.nlm.nih.gov/19801151
Autor:
William M. Barker
Publikováno v:
SAE Technical Paper Series.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fe28fa5e8ae325b7550b697ed74a612
https://doi.org/10.4271/950268
https://doi.org/10.4271/950268
Autor:
Bertrand Le Bourdonnec, Rolf T. Windh, Lara K. Leister, Q. Jean Zhou, Christopher W. Ajello, Minghua Gu, Guo-Hua Chu, Paul A. Tuthill, William M. Barker, Michael Koblish, Daniel D. Wiant, Thomas M. Graczyk, Serge Belanger, Joel A. Cassel, Marina S. Feschenko, Bernice L. Brogdon, Steven A. Smith, Michael J. Derelanko, Steve Kutz, Patrick J. Little
Publikováno v:
Journal of Medicinal Chemistry; Sep2009, Vol. 52 Issue 18, p5685-5702, 18p