Zobrazeno 1 - 10
of 64
pro vyhledávání: '"William M Philbrick"'
Autor:
Yemsratch T Akalu, Maria E Mercau, Marleen Ansems, Lindsey D Hughes, James Nevin, Emily J Alberto, Xinran N Liu, Li-Zhen He, Diego Alvarado, Tibor Keler, Yong Kong, William M Philbrick, Marcus Bosenberg, Silvia C Finnemann, Antonio Iavarone, Anna Lasorella, Carla V Rothlin, Sourav Ghosh
Publikováno v:
eLife, Vol 11 (2022)
Knockout (KO) mouse models play critical roles in elucidating biological processes behind disease-associated or disease-resistant traits. As a presumed consequence of gene KO, mice display certain phenotypes. Based on insight into the molecular role
Externí odkaz:
https://doaj.org/article/43fad56f4e26479584968f8d6e15f037
Autor:
Sumona Ghosh Lester, lucia eRusso, Simona Simon Ghanem, Saja Sadik Khuder, Anthony Michael DeAngelis, Emily L Esakov, Thomas A Bowman, Garrett eHeinrich, Qusai Y Al-Share, Marcia F McInerney, William M Philbrick, Sonia Michael Najjar
Publikováno v:
Frontiers in Endocrinology, Vol 6 (2015)
CEACAM1 promotes insulin extraction, an event that occurs mainly in liver. Phenocopying global Ceacam1 null mice (Cc1–/–), C57/BL6J mice fed a high-fat diet exhibited reduced hepatic CEACAM1 levels and impaired insulin clearance, followed by hype
Externí odkaz:
https://doaj.org/article/0892afe37c8447e6bba827286aaade08
Autor:
Maria E Mercau, Yemsratch T Akalu, Marleen Ansems, Lindsey D Hughes, James Nevin, Emily J Alberto, Xinran N Liu, Li-Zhen He, Diego Alvarado, Tibor Keler, Yong Kong, William M Philbrick, Marcus Bosenberg, Silvia C Finnemann, Antonio Iavarone, Anna Lasorella, Carla V Rothlin, Sourav Ghosh
Publikováno v:
eLife. 11
Knockout (KO) mouse models play critical roles in elucidating biological processes behind disease-associated or disease-resistant traits. As a presumed consequence of gene KO, mice display certain phenotypes. Based on insight into the molecular role
Autor:
Chryssa Zografou, William M. Philbrick, Vadysirisack Douangsone D, Kevin C. O’Connor, Richard Nowak, Jeffrey Bennett, Abeer H. Obaid, Miriam L. Fichtner, Bailey Munro-Sheldon
Publikováno v:
Neurol Neuroimmunol Neuroinflamm
BackgroundAutoantibodies targeting the acetylcholine receptor (AChR), found in patients with myasthenia gravis (MG), mediate pathology through three mechanisms: complement-directed tissue damage, blocking of the acetylcholine binding site, and intern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a2cf9c3b960ef25c0f911b089ed79c
https://europepmc.org/articles/PMC9352342/
https://europepmc.org/articles/PMC9352342/
Autor:
Maria E Mercau, Yemsratch T Akalu, Marleen Ansems, Lindsey D Hughes, James Nevin, Emily J Alberto, Xinran N Liu, Li-Zhen He, Diego Alvarado, Tibor Keler, Yong Kong, William M Philbrick, Marcus Bosenberg, Silvia C Finnemann, Antonio Iavarone, Anna Lasorella, Carla V Rothlin, Sourav Ghosh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba14842f4a7dffd7017cf17604913bb9
https://doi.org/10.7554/elife.80530.sa2
https://doi.org/10.7554/elife.80530.sa2
Autor:
Yemsratch T. Akalu, Maria E. Mercau, Marleen Ansems, Sagie Wagage, Lindsey D. Hughes, James Nevin, Emily Alberto, Xinran Liu, Li-Zhen He, Diego Alvarado, Tibor Keler, Yong Kong, William M. Philbrick, Silvia C. Finnemann, Antonio Iavarone, Anna Lasorella, Carla V. Rothlin, Sourav Ghosh
Knockout (KO) mouse models play critical roles in elucidating biological processes behind disease-associated or disease-resistant traits. As a consequence of gene KO, mice display certain phenotypes. Based on insight into the molecular role of said g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a53afe50c86ec7173c17637695fbf5c
https://doi.org/10.1101/2022.05.23.493101
https://doi.org/10.1101/2022.05.23.493101
Autor:
Kyle Tretina, Eui-Soon Park, Pradeep Kumar, Bae Hoon Kim, Agnieszka Maminska, John D. MacMicking, William M. Philbrick, Richard A. Flavell
Bacterial lipopolysaccharide (LPS) is one of the most bioactive substances known. Trace amounts trigger robust immunity to infection but also life-threatening sepsis causing millions of deaths each year. LPS contamination of the cytosol elicits a cas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0f8c745a8a64ddeb87e810d5d508a42
https://doi.org/10.1101/2021.08.25.457662
https://doi.org/10.1101/2021.08.25.457662
Autor:
Estifanos N. Habtemichael, Chloe I. Sales, Francesc López-Giráldez, Xavier O. Westergaard, Hanbing Li, Jonathan S. Bogan, Pamela Dann, Stephen G. DeVries, Don T. Li, Joao Paulo Camporez, Gerald I. Shulman, Stacey N. Brown, Sandro M. Hirabara, William M. Philbrick, Diana M. Ruiz, Xinran Liu, Bhavesh S. Sayal, Sofia González Zapata, Daniel F. Vatner, Kenny Y. Wang, Leigh Goedeke
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature metabolism
Universidade de São Paulo (USP)
instacron:USP
Nature metabolism
TUG tethering proteins bind and sequester GLUT4 glucose transporters intracellularly, and insulin stimulates TUG cleavage to translocate GLUT4 to the cell surface and increase glucose uptake. This effect of insulin is independent of phosphatidylinosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee128277fb5c4809393ded802df5555
Autor:
James C. Reed, William M. Philbrick, Kevan C. Herold, Gabriel Betancur, Maria Korah, Paula Preston-Hurlburt, Carrie L. Lucas
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0236921 (2020)
PLoS ONE, Vol 15, Iss 9, p e0236921 (2020)
The receptor for advanced glycation endproducts (RAGE) is expressed in T cells after activation with antigen and is constitutively expressed in T cells from patients at-risk for and with type 1 diabetes mellitus (T1D). RAGE expression was associated
Autor:
Estifanos N. Habtemichael, Diana M. Ruiz, Daming Li, Bhavesh S. Sayal, Camporez Jp, Wang Ky, Henry Li, Sandro M. Hirabara, Xinran Liu, Daniel F. Vatner, Chloe I. Sales, Stephen G. DeVries, Gerald I. Shulman, William M. Philbrick, Francesc López-Giráldez, Xavier O. Westergaard, Jonathan S. Bogan
SummaryMechanisms to coordinately regulate energy expenditure and glucose uptake into muscle and fat cells are not well described. Insulin stimulates glucose uptake in part by causing site-specific endoproteolytic cleavage of TUG, which mobilizes GLU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa879116ceb2fc779c015883b7fe8779
https://doi.org/10.1101/817049
https://doi.org/10.1101/817049