Zobrazeno 1 - 10
of 174
pro vyhledávání: '"William M Pandak"'
Autor:
Anuj Tharakan, Daniel Rodriguez-Agudo, Sheela Damle, Genta Kakiyama, William M. Pandak, Gregorio Gil, Rebecca K. Martin
Publikováno v:
Biochemistry and Biophysics Reports, Vol 40, Iss , Pp 101873- (2024)
StarD5 is an ER stress protein that binds cholesterol and transfers it to the plasma membrane. It additionally binds and regulates 25-hydroxycholesterol (25-HC) levels. However the full function of the StarD5-25-HC axis is unknown. 25-HC has been rec
Externí odkaz:
https://doaj.org/article/425909eb7685452699ca098fa65a991c
Autor:
Xiaoxuan Zhang, Risheng Cao, Runping Liu, Renping Zhao, Yi Huang, Emily C Gurley, Phillip B Hylemon, William M Pandak, Guangji Wang, Luyong Zhang, Xiaokun Li, Huiping Zhou
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90856 (2014)
HIV protease inhibitor (PI), the core component of highly active antiretroviral treatment (HAART) for HIV infection, has been implicated in HAART-associated cardiovascular complications. Our previous studies have demonstrated that activation of endop
Externí odkaz:
https://doaj.org/article/9c82eee064f341f9aa907c63af908d7c
Autor:
Shunlin Ren, Jin Koung Kim, Genta Kakiyama, Daniel Rodriguez-Agudo, William M Pandak, Hae-Ki Min, Yanxia Ning
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103621 (2014)
Oxysterol sulfation plays an important role in regulation of lipid metabolism and inflammatory responses. In the present study, we report the discovery of a novel regulatory sulfated oxysterol in nuclei of primary rat hepatocytes after overexpression
Externí odkaz:
https://doaj.org/article/e8250311858644149af3890f2efe236f
Autor:
Weibin Zha, Guangji Wang, Weiren Xu, Xuyuan Liu, Yun Wang, Beth S Zha, Jian Shi, Qijin Zhao, Phillip M Gerk, Elaine Studer, Phillip B Hylemon, William M Pandak, Huiping Zhou
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54349 (2013)
BackgroundHIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases. We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammato
Externí odkaz:
https://doaj.org/article/48ba76f137a34e8ab09360090c8231ae
Autor:
Weibin Zha, Guang Liang, Jian Xiao, Elaine J Studer, Phillip B Hylemon, William M Pandak, Guangji Wang, Xiaokun Li, Huiping Zhou
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9069 (2010)
HIV protease inhibitor (PI)-induced inflammatory response plays an important role in HIV PI-associated dyslipidemia and cardiovascular complications. This study examined the effect of berberine, a traditional herb medicine, on HIV PI-induced inflamma
Externí odkaz:
https://doaj.org/article/562d5ee929464bc2a1c8cf80b57858de
Autor:
Kei Minowa, Daniel Rodriguez-Agudo, Mitsuyoshi Suzuki, Yamato Muto, Saeko Hirai, Yaping Wang, Lianyong Su, Huiping Zhou, Qun Chen, Edward J. Lesnefsky, Kuniko Mitamura, Shigeo Ikegawa, Hajime Takei, Hiroshi Nittono, Michael Fuchs, William M. Pandak, Genta Kakiyama
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100363- (2023)
CYP7B1 catalyzes mitochondria-derived cholesterol metabolites such as (25R)26-hydroxycholesterol (26HC) and 3β-hydroxy-5-cholesten-(25R)26-oic acid (3βHCA) and facilitates their conversion to bile acids. Disruption of 26HC/3βHCA metabolism in the
Externí odkaz:
https://doaj.org/article/ad9e745a75d64f8194bdbfb5527e40ba
Publikováno v:
Cells, Vol 12, Iss 10, p 1434 (2023)
The rising prevalence of nonalcoholic fatty liver disease (NAFLD)-related cirrhosis highlights the need for a better understanding of the molecular mechanisms responsible for driving the transition of hepatic steatosis (fatty liver; NAFL) to steatohe
Externí odkaz:
https://doaj.org/article/e1966613097e417a8a51cd15658da5ba
Publikováno v:
Cells
Volume 10
Issue 11
Cells, Vol 10, Iss 3027, p 3027 (2021)
Volume 10
Issue 11
Cells, Vol 10, Iss 3027, p 3027 (2021)
Acetaminophen (APAP) overdose is one of the most frequent causes of acute liver failure (ALF). N-acetylcysteine (NAC) is currently being used as part of the standard care in the clinic but its usage has been limited in severe cases, in which liver tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5b004917bef14d360bb317cde0b55e
http://europepmc.org/articles/PMC8616185
http://europepmc.org/articles/PMC8616185
Autor:
Daniel Rodriguez-Agudo, Enrico Gratton, Michael Maceyka, Leonel Malacrida, Carolina Fortes, Jolene J. Windle, William M. Pandak, Genta Kakiyama, Tavis Sparrer, Gregorio Gil, Mark A. Subler
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 6, Pp 1087-1098 (2019)
Journal of lipid research, vol 60, iss 6
Journal of lipid research, vol 60, iss 6
How plasma membrane (PM) cholesterol is controlled is poorly understood. Ablation of the gene encoding the ER stress steroidogenic acute regulatory-related lipid transfer domain (StarD)5 leads to a decrease in PM cholesterol content, a decrease in ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ff6debe28580cf8063e2814a8491a7
http://www.sciencedirect.com/science/article/pii/S0022227520322495
http://www.sciencedirect.com/science/article/pii/S0022227520322495
Autor:
Phillip B. Hylemon, Huiping Zhou, Guang Liang, William M. Pandak, Runping Liu, Emily C. Gurley, Weidong Chen, Xiaojiaoyang Li, Xuan Wang, Derrick Zhao, Jasmohan S. Bajaj, Guanhua Lai, Yanyan Wang, H. Robert Lippman, Weiwei Zhu
Publikováno v:
Hepatology
Activation of hepatic stellate cells (HSCs) represents the primary driving force to promote the progression of chronic cholestatic liver diseases. We previously reported that cholangiocyte-derived exosomal long noncoding RNA-H19 (lncRNA-H19) plays a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1397189b2e0ded9f9d9525a9c72eaf
https://doi.org/10.1002/hep.30662
https://doi.org/10.1002/hep.30662