Zobrazeno 1 - 10
of 196
pro vyhledávání: '"William M Pandak"'
Autor:
Xiaoxuan Zhang, Risheng Cao, Runping Liu, Renping Zhao, Yi Huang, Emily C Gurley, Phillip B Hylemon, William M Pandak, Guangji Wang, Luyong Zhang, Xiaokun Li, Huiping Zhou
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90856 (2014)
HIV protease inhibitor (PI), the core component of highly active antiretroviral treatment (HAART) for HIV infection, has been implicated in HAART-associated cardiovascular complications. Our previous studies have demonstrated that activation of endop
Externí odkaz:
https://doaj.org/article/9c82eee064f341f9aa907c63af908d7c
Autor:
Shunlin Ren, Jin Koung Kim, Genta Kakiyama, Daniel Rodriguez-Agudo, William M Pandak, Hae-Ki Min, Yanxia Ning
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103621 (2014)
Oxysterol sulfation plays an important role in regulation of lipid metabolism and inflammatory responses. In the present study, we report the discovery of a novel regulatory sulfated oxysterol in nuclei of primary rat hepatocytes after overexpression
Externí odkaz:
https://doaj.org/article/e8250311858644149af3890f2efe236f
Autor:
Weibin Zha, Guangji Wang, Weiren Xu, Xuyuan Liu, Yun Wang, Beth S Zha, Jian Shi, Qijin Zhao, Phillip M Gerk, Elaine Studer, Phillip B Hylemon, William M Pandak, Huiping Zhou
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54349 (2013)
BackgroundHIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases. We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammato
Externí odkaz:
https://doaj.org/article/48ba76f137a34e8ab09360090c8231ae
Autor:
Weibin Zha, Guang Liang, Jian Xiao, Elaine J Studer, Phillip B Hylemon, William M Pandak, Guangji Wang, Xiaokun Li, Huiping Zhou
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9069 (2010)
HIV protease inhibitor (PI)-induced inflammatory response plays an important role in HIV PI-associated dyslipidemia and cardiovascular complications. This study examined the effect of berberine, a traditional herb medicine, on HIV PI-induced inflamma
Externí odkaz:
https://doaj.org/article/562d5ee929464bc2a1c8cf80b57858de
Autor:
Kei Minowa, Daniel Rodriguez-Agudo, Mitsuyoshi Suzuki, Yamato Muto, Saeko Hirai, Yaping Wang, Lianyong Su, Huiping Zhou, Qun Chen, Edward J. Lesnefsky, Kuniko Mitamura, Shigeo Ikegawa, Hajime Takei, Hiroshi Nittono, Michael Fuchs, William M. Pandak, Genta Kakiyama
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100363- (2023)
CYP7B1 catalyzes mitochondria-derived cholesterol metabolites such as (25R)26-hydroxycholesterol (26HC) and 3β-hydroxy-5-cholesten-(25R)26-oic acid (3βHCA) and facilitates their conversion to bile acids. Disruption of 26HC/3βHCA metabolism in the
Externí odkaz:
https://doaj.org/article/ad9e745a75d64f8194bdbfb5527e40ba
Publikováno v:
Cells, Vol 12, Iss 10, p 1434 (2023)
The rising prevalence of nonalcoholic fatty liver disease (NAFLD)-related cirrhosis highlights the need for a better understanding of the molecular mechanisms responsible for driving the transition of hepatic steatosis (fatty liver; NAFL) to steatohe
Externí odkaz:
https://doaj.org/article/e1966613097e417a8a51cd15658da5ba
Autor:
Genta Kakiyama, Dalila Marques, Rebecca Martin, Hajime Takei, Daniel Rodriguez-Agudo, Sandra A. LaSalle, Taishi Hashiguchi, Xiaoying Liu, Richard Green, Sandra Erickson, Gregorio Gil, Michael Fuchs, Mitsuyoshi Suzuki, Tsuyoshi Murai, Hiroshi Nittono, Phillip B. Hylemon, Huiping Zhou, William M. Pandak
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1629-1644 (2020)
NAFLD is an important public health issue closely associated with the pervasive epidemics of diabetes and obesity. Yet, despite NAFLD being among the most common of chronic liver diseases, the biological factors responsible for its transition from be
Externí odkaz:
https://doaj.org/article/f22dc345203d48c1bae1f66f709fdca2
Autor:
William M. Pandak, Genta Kakiyama
Publikováno v:
Liver Research, Vol 3, Iss 2, Pp 88-98 (2019)
Over the last two decades, the prevalence of obesity, and metabolic syndromes (MS) such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), have dramatically increased. Bile acids play a major role in the digestion, abso
Externí odkaz:
https://doaj.org/article/fb8f2d218a3d4218a405103292cfb80c
Autor:
Daniel Rodriguez-Agudo, Leonel Malacrida, Genta Kakiyama, Tavis Sparrer, Carolina Fortes, Michael Maceyka, Mark A. Subler, Jolene J. Windle, Enrico Gratton, William M. Pandak, Gregorio Gil
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 6, Pp 1087-1098 (2019)
How plasma membrane (PM) cholesterol is controlled is poorly understood. Ablation of the gene encoding the ER stress steroidogenic acute regulatory-related lipid transfer domain (StarD)5 leads to a decrease in PM cholesterol content, a decrease in ch
Externí odkaz:
https://doaj.org/article/b9c9fc18d2e84c2ebc2b6623be3dd211
Autor:
Yanyan Wang, Yun-Ling Tai, Derrick Zhao, Yuan Zhang, Junkai Yan, Genta Kakiyama, Xuan Wang, Emily C. Gurley, Jinze Liu, Jinpeng Liu, Jimin Liu, Guanhua Lai, Phillip B. Hylemon, William M. Pandak, Weidong Chen, Huiping Zhou
Publikováno v:
Cells, Vol 10, Iss 2, p 210 (2021)
Background and Aims: The disease progression of nonalcoholic fatty liver disease (NAFLD) from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) is driven by multiple factors. Berberine (BBR) is an ancient Chinese medicine and has various
Externí odkaz:
https://doaj.org/article/196a8eaf79bc4c698900c2d12f6a79c8