Zobrazeno 1 - 10
of 88
pro vyhledávání: '"William M Old"'
Autor:
Andrew B Morgenthaler, Wallis R Kinney, Christopher C Ebmeier, Corinne M Walsh, Daniel J Snyder, Vaughn S Cooper, William M Old, Shelley D Copley
Publikováno v:
eLife, Vol 8 (2019)
New enzymes often evolve by gene amplification and divergence. Previous experimental studies have followed the evolutionary trajectory of an amplified gene, but have not considered mutations elsewhere in the genome when fitness is limited by an evolv
Externí odkaz:
https://doaj.org/article/4eadcc7a4c55458a92354cb207467c04
Autor:
JohnCarlo Kristofich, Andrew B Morgenthaler, Wallis R Kinney, Christopher C Ebmeier, Daniel J Snyder, William M Old, Vaughn S Cooper, Shelley D Copley
Publikováno v:
PLoS Genetics, Vol 14, Iss 8, p e1007615 (2018)
Synonymous mutations do not alter the specified amino acid but may alter the structure or function of an mRNA in ways that impact fitness. There are few examples in the literature, however, in which the effects of synonymous mutations on microbial gr
Externí odkaz:
https://doaj.org/article/13324c5830f64e058f7351d732925e53
Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir
Autor:
Alex C Stabell, Nicholas R Meyerson, Rebekah C Gullberg, Alison R Gilchrist, Kristofor J Webb, William M Old, Rushika Perera, Sara L Sawyer
Publikováno v:
eLife, Vol 7 (2018)
Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not reach high titers in primate models. This presents a unique opportunity to examine the genetics of spillover versus reservoir hosts. The dengue virus 2 (DENV2) -
Externí odkaz:
https://doaj.org/article/43a1738476414835bfbd06fdae5b31d1
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182804 (2017)
Understanding the pathophysiology of Alzheimer disease has relied upon the use of amyloid peptides from a variety of sources, but most predominantly synthetic peptides produced using t-butyloxycarbonyl (Boc) or 9-fluorenylmethoxycarbonyl (Fmoc) chemi
Externí odkaz:
https://doaj.org/article/969df48db4b54b45a1ff335a847df2be
Autor:
Jennifer S Avena, Shannon Burns, Zulin Yu, Christopher C Ebmeier, William M Old, Sue L Jaspersen, Mark Winey
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004666 (2014)
Duplication of centrosomes once per cell cycle is essential for bipolar spindle formation and genome maintenance and is controlled in part by cyclin-dependent kinases (Cdks). Our study identifies Sfi1, a conserved component of centrosomes, as the fir
Externí odkaz:
https://doaj.org/article/465ba8b744de49d0ac008a624402374a
Autor:
Arijit Chakraborty, Arunava Bandyopadhaya, Vijay K Singh, Filip Kovacic, Sujin Cha, William M Oldham, A Aria Tzika, Laurence G Rahme
Publikováno v:
eLife, Vol 13 (2024)
How bacterial pathogens exploit host metabolism to promote immune tolerance and persist in infected hosts remains elusive. To achieve this, we show that Pseudomonas aeruginosa (PA), a recalcitrant pathogen, utilizes the quorum sensing (QS) signal 2
Externí odkaz:
https://doaj.org/article/d545ff885eb5410092dedd196b9b7566
Autor:
Cheryl N. Miller, Jong-Duk Park, Jeremy Jacobsen, Kyuho Moon, David DeShazer, Dainan Mao, Fei Xu, Christopher C. Ebmeier, Mohammad R. Seyedsayamdost, Jessica Rose, William M. Old
Publikováno v:
ACS Chemical Biology. 15:1195-1203
Burkholderia thailandensis has emerged as a model organism for investigating the production and regulation of diverse secondary metabolites. Most of the biosynthetic gene clusters encoded in B. thailandensis are silent, motivating the development of
Autor:
Tetsuya Kawaguchi, William M. Old, Christopher C. Ebmeier, Andres A. Morera, Mahta Moinpour, Jacob C. Schwartz, Matthew Rollins
Publikováno v:
Journal of Proteome Research
The RNA-binding proteins TDP-43 and FUS are tied as the third leading known genetic cause for amyotrophic lateral sclerosis (ALS), and TDP-43 proteopathies are found in nearly all ALS patients. Both the natural function and contribution to pathology
Autor:
Westley Heydeck, Daniela Nicastro, Amy S. Fabritius, Brian A. Bayless, Christopher C. Ebmeier, Chidambaram Nachiappan, Justen B. Whittall, Tess Gunnels, Daniel Stoddard, David A. Agard, William M. Old, Sam Li, Lauren Anderson, Mark Winey
Publikováno v:
Molecular biology of the cell, vol 32, iss 21
The core structure of motile cilia and flagella, the axoneme, is built from a stable population of doublet microtubules. This unique stability is brought about, at least in part, by a network of microtubule inner proteins (MIPs) that are bound to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e13b1603954313603a5c841f3313da
https://escholarship.org/uc/item/681594gj
https://escholarship.org/uc/item/681594gj
Autor:
Kristofor J. Webb, Kerri A. Ball, Xiaoyun Ding, William M. Old, Yonghui Ding, Yu Gao, Michael H. B. Stowell, Angelo D'Alessandro
Thermal shift assays (TSAs) have been extensively used to study thermodynamics of proteins and provide an efficient means to assess protein-ligand binding or protein-protein interactions. However, existing TSAs have limitations, such as being time co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895149b96e7e9e92dbf229f06d89507b
http://arxiv.org/abs/2108.04935
http://arxiv.org/abs/2108.04935