Lead Exposure Induces Telomere Instability in Human Cells.

Autor: Géraldine Pottier, Muriel Viau, Michelle Ricoul, Grace Shim, Marion Bellamy, Corina Cuceu, William M Hempel, Laure Sabatier

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e67501 (2013)

Lead (Pb) is an important environmental contaminant due to its widespread use over many centuries. While it affects primarily every organ system of the body, the most pernicious effects of Pb are on the central nervous system leading to cognitive and

Externí odkaz: https://doaj.org/article/12d04e554f2d45038048d3a9f8a3a816

Transmission of Induced Chromosomal Aberrations through Successive Mitotic Divisions in Human Lymphocytes after In Vitro and In Vivo Radiation

Autor: Akram Kaddour, Bruno Colicchio, Diane Buron, Elie El Maalouf, Eric Laplagne, Claire Borie, Michelle Ricoul, Aude Lenain, William M. Hempel, Luc Morat, Mustafa Al Jawhari, Corina Cuceu, Leonhard Heidingsfelder, Eric Jeandidier, Georges Deschênes, Alain Dieterlen, Michèle El May, Theodore Girinsky, Annelise Bennaceur-Griscelli, Patrice Carde, Laure Sabatier, Radhia M’kacher

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract The mechanisms behind the transmission of chromosomal aberrations (CA) remain unclear, despite a large body of work and major technological advances in chromosome identification. We reevaluated the transmission of CA to second- and third-div

Externí odkaz: https://doaj.org/article/4d919127e5124bc98a5cd9b87f10782d

Benefit of an association of an antioxidative substrate and a traditional chinese medicine on telomere elongation

Autor: Michel Frey, Bruno Colicchio, Mustafa Al Jawhari, Eric Jeandidier, Henry Puget, Lionel Breton, Radhia M'kacher, William M. Hempel

Publikováno v: Cellular and Molecular Biology. 65:54-58

Telomere shortening is involved in age-related disorders, such as cancer and cardiovascular diseases. Recently, telomerase re-activation strategies have been proposed to counteract telomere shortening and its consequences. Here, we investigated the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51088d9ca4db1c2fc29a300239dc0dc3
https://doi.org/10.14715/cmb/2019.65.8.9

Telomere and Centromere Staining Followed by M-FISH Improves Diagnosis of Chromosomal Instability and Its Clinical Utility

Autor: Wendy Kerbrat, Annelise Bennaceur-Griscelli, Philippe Voisin, Kevin Soehnlen, Wala Najar, Valentine Marquet, Marguerite Miguet, Andreas Plesch, Claire Borie, William M. Hempel, Nadège Wilhelm-Murer, Catherine Yardin, Anne-Claude Tabet, Noufissa Oudrhiri, Georges Deschenes, Michael Fenech, Bruno Colicchio, Micheline Fontaine Arnoux, Eric Jeandidier, Radhia M'kacher, Catherine Ferrapie, Alain Dieterlen, Theodore Girinsky, Leonhard Heidingsfelder, Patrice Carde, Steffen Junker

Publikováno v: Genes
Volume 11
Issue 5
M’kacher, R, Colicchio, B, Borie, C, Junker, S, Marquet, V, Heidingsfelder, L, Soehnlen, K, Najar, W, Hempel, W M, Oudrhiri, N, Wilhelm-Murer, N, Miguet, M, Arnoux, M, Ferrapie, C, Kerbrat, W, Plesch, A, Dieterlen, A, Girinsky, T, Voisin, P, Deschenes, G, Tabet, A C, Yardin, C, Bennaceur-Griscelli, A, Fenech, M, Carde, P & Jeandidier, E 2020, ' Telomere and centromere staining followed by m-fish improves diagnosis of chromosomal instability and its clinical utility ', Genes, vol. 11, no. 5, 475 . https://doi.org/10.3390/genes11050475
Genes, Vol 11, Iss 475, p 475 (2020)

Dicentric chromosomes are a relevant marker of chromosomal instability. Their appearance is associated with telomere dysfunction, leading to cancer progression and a poor clinical outcome. Here, we present Telomere and Centromere staining followed by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e01b6535156e46bc1fa6cc62b2d0903

A new tool for genotoxic risk assessment: Reevaluation of the cytokinesis-block micronucleus assay using semi-automated scoring following telomere and centromere staining

Autor: Mustafa Al Jawhari, Olivier Cariou, Bruno Colicchio, Patrice Carde, Leonhard Heidingsfelder, William M. Hempel, Besma Bel Hadj Jrad, Alain Dieterlen, Philippe Voisin, Eric Laplagne, Radhia M'kacher, Narjes Zaguia, Eric Jeandidier

Publikováno v: Mutation research. Genetic toxicology and environmental mutagenesis.

Background The cytokinesis-block micronucleus (CBMN) assay is an internationally recognized method for measuring DNA damage after exposure to genotoxic agents, as well as a biomarker for DNA repair and chromosomal instability. The high baseline level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1aa8f9a56b299b4434b0f4734112cf
https://pubmed.ncbi.nlm.nih.gov/32247554