Zobrazeno 1 - 10
of 474
pro vyhledávání: '"William M Gallagher"'
Autor:
Sofie Olsson Hau, Sara Wahlin, Sophie Cervin, Vilgot Falk, Björn Nodin, Jacob Elebro, Jakob Eberhard, Bruce Moran, William M Gallagher, Emelie Karnevi, Karin Jirström
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 1, Pp 65-77 (2022)
Abstract The outlook for patients with pancreatic cancer remains dismal. Treatment options are limited and chemotherapy remains standard of care, leading to only modest survival benefits. Hence, there is a great need to further explore the mechanisti
Externí odkaz:
https://doaj.org/article/636b8c745cbd42caa4d4e025acbae2fc
Autor:
Alex J Eustace, Neil T Conlon, Martina S J McDermott, Brigid C Browne, Patrick O’Leary, Frankie A Holmes, Virginia Espina, Lance A Liotta, Joyce O’Shaughnessy, Clair Gallagher, Lorraine O’Driscoll, Sweta Rani, Stephen F Madden, Neil A O’Brien, Charles Ginther, Dennis Slamon, Naomi Walsh, William M Gallagher, Radoslaw Zagozdzon, William R Watson, Norma O’Donovan, John Crown
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background Lapatinib has clinical efficacy in the treatment of trastuzumab-refractory HER2-positive breast cancer. However, a significant proportion of patients develop progressive disease due to acquired resistance to the drug. Induction of
Externí odkaz:
https://doaj.org/article/5de7181f330d45b98eeaa2bf7e64c819
Autor:
Alice C O'Farrell, Rhys Evans, Johanna M U Silvola, Ian S Miller, Emer Conroy, Suzanne Hector, Maurice Cary, David W Murray, Monika A Jarzabek, Ashwini Maratha, Marina Alamanou, Girish Mallya Udupi, Liam Shiels, Celine Pallaud, Antti Saraste, Heidi Liljenbäck, Matti Jauhiainen, Vesa Oikonen, Axel Ducret, Paul Cutler, Fionnuala M McAuliffe, Jacques A Rousseau, Roger Lecomte, Suzanne Gascon, Zoltan Arany, Bonnie Ky, Thomas Force, Juhani Knuuti, William M Gallagher, Anne Roivainen, Annette T Byrne
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169964 (2017)
Sunitinib is a tyrosine kinase inhibitor approved for the treatment of multiple solid tumors. However, cardiotoxicity is of increasing concern, with a need to develop rational mechanism driven approaches for the early detection of cardiac dysfunction
Externí odkaz:
https://doaj.org/article/a50b8f08c3d74280a693b5b4bb9f1718
Autor:
Lorraine Burke, Clare T. Butler, Adrian Murphy, Bruce Moran, William M Gallagher, Jacintha O'Sullivan, Breandán N. Kennedy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 4 (2016)
Colorectal cancer is the third most common cancer worldwide and is associated with significant morbidity and mortality. Current pharmacotherapy options include cytotoxic chemotherapy, anti-VEGF and anti-EGFR targeting drugs, but these are limited by
Externí odkaz:
https://doaj.org/article/2c5f16fdaf7f40b5a9679f037c072895
Autor:
Kate Connor, Emer Conroy, Kieron White, Liam P. Shiels, Simon Keek, Abdalla Ibrahim, William M. Gallagher, Kieron J. Sweeney, James Clerkin, David O’Brien, Jane B. Cryan, Philip J. O’Halloran, Josephine Heffernan, Francesca Brett, Philippe Lambin, Henry C. Woodruff, Annette T. Byrne
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Here, we establish a CT-radiomics based method for application in invasive, orthotopic rodent brain tumour models. Twenty four NOD/SCID mice were implanted with U87R-Luc2 GBM cells and longitudinally imaged via contrast enhanced (CE-CT) imag
Externí odkaz:
https://doaj.org/article/f5502ff7e06945ad8173541c1ee43f95
Autor:
Gillian O'Hurley, Christer Busch, Linn Fagerberg, Björn M Hallström, Charlotte Stadler, Anna Tolf, Emma Lundberg, Jochen M Schwenk, Karin Jirström, Anders Bjartell, William M Gallagher, Mathias Uhlén, Fredrik Pontén
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0133449 (2015)
To better understand prostate function and disease, it is important to define and explore the molecular constituents that signify the prostate gland. The aim of this study was to define the prostate specific transcriptome and proteome, in comparison
Externí odkaz:
https://doaj.org/article/59ff769d9ca449d28ad14f11428ec800
Autor:
Elton Rexhepaj, Margrét Agnarsdóttir, Julia Bergman, Per-Henrik Edqvist, Michael Bergqvist, Mathias Uhlén, William M Gallagher, Emma Lundberg, Fredrik Ponten
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62070 (2013)
AimsImmunohistochemistry is a routine practice in clinical cancer diagnostics and also an established technology for tissue-based research regarding biomarker discovery efforts. Tedious manual assessment of immunohistochemically stained tissue needs
Externí odkaz:
https://doaj.org/article/0b0093dc71424933a9e09b0c9152cdd8
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e5001 (2009)
Alternative splicing (AS) is an intrinsic regulatory mechanism of all metazoans. Recent findings suggest that 100% of multiexonic human genes give rise to splice isoforms. AS can be specific to tissue type, environment or developmentally regulated. S
Externí odkaz:
https://doaj.org/article/ee407ed5692a44268a82065db8168e9c
Autor:
Ian S. Miller, Sonja Khan, Liam P. Shiels, Sudipto Das, Alice C. O' Farrell, Kate Connor, Adam Lafferty, Bruce Moran, Claudio Isella, Paul Loadman, Emer Conroy, Susan Cohrs, Roger Schibli, Robert S. Kerbel, William M. Gallagher, Elisabetta Marangoni, Kathleen Bennett, Darran P. O' Connor, Róisín M. Dwyer, Annette T. Byrne
Publikováno v:
Cancer Medicine, Vol 11, Iss 20, Pp 3820-3836 (2022)
Abstract Backgorund Prior data suggest pre‐diagnostic aspirin use impacts breast tumour biology and patient outcome. Here, we employed faithful surgical resection models of HER2+ and triple‐negative breast cancer (TNBC), to study outcome and resp
Externí odkaz:
https://doaj.org/article/1f5177ae512441ffab056e955c214925
Autor:
Kayleigh Slater, Rosa Bosch, Kaelin Francis Smith, Chowdhury Arif Jahangir, Sandra Garcia-Mulero, Arman Rahman, Fiona O’Connell, Josep M. Piulats, Valerie O’Neill, Noel Horgan, Sarah E. Coupland, Jacintha O’Sullivan, William M. Gallagher, Alberto Villanueva, Breandán N. Kennedy
Publikováno v:
Frontiers in Medicine, Vol 9 (2023)
Uveal melanoma (UM) is an intraocular cancer with propensity for liver metastases. The median overall survival (OS) for metastatic UM (MUM) is 1.07 years, with a reported range of 0.84–1.34. In primary UM, high cysteinyl leukotriene receptor 1 (Cys
Externí odkaz:
https://doaj.org/article/eac8866d1abb4c86aceb6f7196a8a3cd