Zobrazeno 1 - 10
of 68
pro vyhledávání: '"William M Clark"'
Publikováno v:
J Grad Med Educ
Background Graduate medical education (GME) has emphasized the assessment of trainee competencies and milestones; however, sufficient in-person assessment is often constrained. Using mobile hands-free devices, such as Google Glass (GG) for telemedici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b1b825c5431afd9aa447104f7a13d4
https://doi.org/10.4300/jgme-d-19-00148.1
https://doi.org/10.4300/jgme-d-19-00148.1
Publikováno v:
1998 Annual Conference Proceedings.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f5369da36a23fb3413442716c12e2aa
https://doi.org/10.18260/1-2--7370
https://doi.org/10.18260/1-2--7370
Publikováno v:
JAMA Ophthalmology. 139:1321
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb63346ec184ecf675f311703adbc48e
https://doi.org/10.1001/jamaophthalmol.2021.1461
https://doi.org/10.1001/jamaophthalmol.2021.1461
Autor:
Brett J Schneider, Robert E. O'Connor, Brian S. Gunnell, Jack Cote, George M Lindbeck, Haydon M. Pitchford, Debra G. Perina, Nicole A Chiota-McCollum, William M Clark, Sherita N Chapman Smith, Andrew M. Southerland, Bradford B. Worrall, Nina J Solenski
Publikováno v:
Stroke. 48
Introduction: Modern advances in acute stroke care place an added emphasis on accurate prehospital diagnosis and triage. As part of the Improving Treatment with Rapid Evaluation of Acute Stroke via mobile Telemedicine (iTREAT) study, we assessed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93207f079f9d7a485b234db9cdbfaad3
https://doi.org/10.1161/str.48.suppl_1.tp246
https://doi.org/10.1161/str.48.suppl_1.tp246
Publikováno v:
Bioresource Technology. 136:771-774
Quantification of a pH change that was observed over the course of the transesterification reaction that converts vegetable oil to biodiesel may provide a simple method to monitor the reaction. Transesterification of canola oil at 6:1 methanol to oil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07d5e068e84f153cb95cbb460b278a9
https://doi.org/10.1016/j.biortech.2013.03.089
https://doi.org/10.1016/j.biortech.2013.03.089
Autor:
Mark A. Lindblad, William M. Clark
Publikováno v:
Separation Science and Technology. 46:1546-1554
Numerical modeling results for electrophoresis in aqueous two-phase systems are shown to agree with experimental results in both batch and flow devices. A previously discovered polarization effect due to the phase partitioning is further investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::408ee82289e994927011c7a460d2fa88
https://doi.org/10.1080/01496395.2011.573518
https://doi.org/10.1080/01496395.2011.573518
Publikováno v:
Organic Process Research & Development. 15:123-130
In developing the manufacturing route for the cathepsin K inhibitor SB-462795, the oxidation of a secondary alcohol for the final chemical stage is described. Prospective conditions were limited by several factors, particularly general safety concern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ba1adeff8dc4fe4f109595897c937c2
https://doi.org/10.1021/op100266s
https://doi.org/10.1021/op100266s
Publikováno v:
Journal of Molecular Structure. 984:246-261
An unusual electrocyclized photo-degradation product of an EP 1 antagonist drug candidate, 6-(2-(5-chloro-2-(2,4-difluorobenyzloxy) phenyl) cyclopent-1-enyl) picolinic acid, is characterized by liquid chromatography (LC) with mass spectrometry (MS) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e06e8febf439463e57bc8cc6c2361096
https://doi.org/10.1016/j.molstruc.2010.09.036
https://doi.org/10.1016/j.molstruc.2010.09.036
Autor:
William M. Clark, Huan Wang, Doan Brian Daniel, Xi Ouyang, Hayao Matsuhashi, Steven N. Goodman
Publikováno v:
Tetrahedron. 65:6291-6303
Two stereoselective syntheses of SB-462795, a highly potent cathepsin K inhibitor, are described. Both routes feature a C5–C6 disconnection by ring closing metathesis to construct an azepane ring and are amenable to large-scale manufacturing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f446df72477928a1704261f785712192
https://doi.org/10.1016/j.tet.2009.06.022
https://doi.org/10.1016/j.tet.2009.06.022
Publikováno v:
Organic Process Research & Development. 12:226-234
The development of a robust and high-yielding ring-closing metathesis (RCM) reaction and its demonstration on multikilogram scale are described. A detailed understanding of the impact of impurities on the RCM reaction was achieved using a variety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28b670e8921565bc5b4f40f086f00f62
https://doi.org/10.1021/op700288p
https://doi.org/10.1021/op700288p