Zobrazeno 1 - 10
of 212
pro vyhledávání: '"William M Abraham"'
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224764 (2019)
The purpose of this investigation was to ascertain whether nitric oxide (NO) released into the circulation by a noninvasive technology called whole body periodic acceleration (WBPA) could increase mucociliary clearance (MCC). It was based on observat
Externí odkaz:
https://doaj.org/article/1d0dbdb5959f41369b05b1140d0724ac
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53932 (2013)
INTRODUCTION: Acute metabolic acidosis impairs cardiovascular function and increases the mortality of critically ill patients. However, the precise mechanism(s) underlying these effects remain unclear. We hypothesized that targeting pH-regulatory pro
Externí odkaz:
https://doaj.org/article/a06c57cc99a943f8b80cd1fd44c02de0
Autor:
Patrick F Dillon, Robert Root-Bernstein, N Edward Robinson, William M Abraham, Catherine Berney
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15130 (2010)
RATIONALE: Previous in vitro research demonstrated that ascorbate enhances potency and duration of activity of agonists binding to alpha 1 adrenergic and histamine receptors. OBJECTIVES: Extending this work to beta 2 adrenergic systems in vitro and i
Externí odkaz:
https://doaj.org/article/f9ca3886e6854b52b0d76abf8c6b8319
Autor:
Allan Goodman, Jennifer R. McCall, Henry M. Jacocks, Alysha Thompson, Daniel Baden, William M. Abraham, Andrea Bourdelais
Publikováno v:
Marine Drugs, Vol 12, Iss 4, Pp 1839-1858 (2014)
Brevenal is a ladder frame polyether produced by the dinoflagellate Karenia brevis. This organism is also responsible for the production of the neurotoxic compounds known as brevetoxins. Ingestion or inhalation of the brevetoxins leads to adverse eff
Externí odkaz:
https://doaj.org/article/62902a7e8922420082b37eb3c9adab7e
Autor:
Sebastian F. Salathe, Nathalie Baumlin, Philip L. Whitney, Juan R. Sabater, Matthias Salathe, Michael D. Kim, Adam Wanner, Frank T. Horrigan, Juliette Sailland, William M. Abraham, John Dennis, Deepika Polineni, Joseph K. David, Charles A. Peloquin, Makoto Yoshida
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 201:313-324
Rationale: Despite therapeutic progress in treating cystic fibrosis (CF) airway disease, airway inflammation with associated mucociliary dysfunction remains largely unaddressed. Inflammation reduces the activity of apically expressed large-conductanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bd04dfe0cfb6fdd7abb028bd678e736
https://doi.org/10.1164/rccm.201905-0990oc
https://doi.org/10.1164/rccm.201905-0990oc
Autor:
William M. Abraham, Sebastian F. Salathe, Phillip L Whitney, Juan R. Sabater, Samuel Chung, Nathalie Baumlin, Robert B. Moore, John S. Dennis, Michael D Kim, Matthias Salathe
Publikováno v:
Am J Respir Crit Care Med
Rationale: Electronic cigarette (e-cig) use has been widely adopted under the perception of safety. However, possibly adverse effects of e-cig vapor in never-smokers are not well understood. Objectives: To test the effects of nicotine-containing e-ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9854a5d1224a099818bddf0125ae45
https://doi.org/10.1164/rccm.201811-2087oc
https://doi.org/10.1164/rccm.201811-2087oc
Autor:
Mehmet Kesimer, Jerome Carpenter, Juliana I. Sesma, Boris Reidel, Patrick J. Moore, Alaina L. Garland, Robert Tarran, Christine S. Kim, Juan R. Sabater, David W. Scott, Scott H. Randell, Robert C. Fellner, William J. Arendshorst, William M. Abraham, Shawn T Terryah, Saira Ahmad
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 314:L192-L205
In cystic fibrosis (CF) lungs, epithelial Na+ channel (ENaC) hyperactivity causes a reduction in airway surface liquid volume, leading to decreased mucocilliary clearance, chronic bacterial infection, and lung damage. Inhibition of ENaC is an attract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b42219e59688ffee272ba234b91e8ff
https://doi.org/10.1152/ajplung.00546.2016
https://doi.org/10.1152/ajplung.00546.2016
Autor:
William M. Abraham, Dale J. Christensen, Juan R. Sabater, David W. Scott, Matthew P. Walker, Bryant Wu, Timothy J. Stuhlmiller, Juliana I. Sesma, Robert Tarran, Timothy M. Crowder
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 196:734-744
Rationale: Cystic fibrosis (CF) lung disease is caused by the loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) combined with hyperactivation of the epithelial sodium channel (ENaC). In the lung, ENaC is responsible f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64f2e08f65d7323841ff070db75eccca
https://doi.org/10.1164/rccm.201612-2445oc
https://doi.org/10.1164/rccm.201612-2445oc
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 11, p e0224764 (2019)
PLoS ONE, Vol 14, Iss 11, p e0224764 (2019)
The purpose of this investigation was to ascertain whether nitric oxide (NO) released into the circulation by a noninvasive technology called whole body periodic acceleration (WBPA) could increase mucociliary clearance (MCC). It was based on observat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e179c1c8385f2a3202329691a45dbc
http://europepmc.org/articles/PMC6837306
http://europepmc.org/articles/PMC6837306
Autor:
Henri Doods, Malarvizhi Gurusamy, Birgit Jung, Saeed Nasseri, William M. Abraham, Dongwon Lee, Gilson Khang, Dongmei Wu, Hana Lee
Publikováno v:
Pharmacological Research. 104:132-139
Kinin B1 receptors are implicated in asthmatic airway inflammation. Here we tested this hypothesis by examining the anti-inflammatory effects of BI113823, a novel non-peptide orally active kinin B1 receptor antagonist in mice sensitized to ovalbumin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738b9cb04306e1e9516764366f3f9638
https://doi.org/10.1016/j.phrs.2015.12.017
https://doi.org/10.1016/j.phrs.2015.12.017