Zobrazeno 1 - 10
of 189
pro vyhledávání: '"William Lijinsky"'
Autor:
Graziella Filippini, A. H. Cardy, Raphael Peris-Bonet, Margaret R. E. McCredie, William Lijinsky, Beth A. Mueller, Julian Little, N. Won Choi, Elizabeth A. Holly, Flora Lubin, Sylvanie Cordier, Susan Preston-Martin, Annie Arslan, Roberta McKean-Cowdin
Publikováno v:
International Journal of Cancer
International Journal of Cancer, Wiley, 2006, 118 (5), pp.1302-8. ⟨10.1002/ijc.21482⟩
International Journal of Cancer, 2006, 118 (5), pp.1302-8. ⟨10.1002/ijc.21482⟩
International Journal of Cancer, Wiley, 2006, 118 (5), pp.1302-8. ⟨10.1002/ijc.21482⟩
International Journal of Cancer, 2006, 118 (5), pp.1302-8. ⟨10.1002/ijc.21482⟩
International audience; N-nitroso compounds (NOC) have been associated with carcinogenesis in a wide range of species, including humans. There is strong experimental data showing that nitrosamides (R(1)NNO.COR(2)), a type of NOC, are potent neuro-car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6df79acf4321fa8bc4ed7f346ccbdc
https://doi.org/10.1002/ijc.21482
https://doi.org/10.1002/ijc.21482
Autor:
William Lijinsky
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 443:129-138
N-Nitroso compounds were known almost 40 years ago to be present in food treated with sodium nitrite, which made fish meal hepatotoxic to animals through formation of nitrosodimethylamine (NDMA). Since that time, N-nitroso compounds have been shown i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fc09bf9cded425a13477b56b9355cf
https://doi.org/10.1016/s1383-5742(99)00015-0
https://doi.org/10.1016/s1383-5742(99)00015-0
Autor:
William Lijinsky
Publikováno v:
Carcinogenesis. 16:675-681
Tumors induced in approximately 2000 F344 rats by a number of carcinogenic N-nitroso compounds have been examined for their propensity to metastasize. The objective was to discover relations between the structure of the carcinogen, the tumor induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8687a8f11ea8fe5e11b45b816855b4
https://doi.org/10.1093/carcin/16.4.675
https://doi.org/10.1093/carcin/16.4.675
Publikováno v:
Japanese Journal of Cancer Research : Gann
Many alkylating agents are potent carcinogens and there is considerable evidence that the formation of O6-alkylguanine in DNA can lead to mutations and the initiation of neoplastic growth. The repair of O6-methyl- or O6-ethylguanine in DNA is known t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17816b31e3be1e930173f282c2c7ad05
http://europepmc.org/articles/PMC5919443
http://europepmc.org/articles/PMC5919443
Publikováno v:
Journal of Toxicology and Environmental Health. 39:527-538
The incidence of a set of neoplasms arising "spontaneously" in Fischer 344 (F344) rats was determined in control and carcinogen-treated animals. Data were obtained from approximately 9000 rats (4000 males and 5000 females) used to study the carcinoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ccd12ffb33357ba8a36817a798c3e6
https://doi.org/10.1080/15287399309531769
https://doi.org/10.1080/15287399309531769
Publikováno v:
Carcinogenesis. 14:1189-1193
Metabolites produced by enzymic oxidation are believed to be responsible for the mutagenicity and carcinogenicity of N-nitrosamines. Although alpha-hydroxy compounds are often considered, a related and more stable oxidation product, the alpha-carbony
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d01fb1ddf1321bdd748f202cfb8e936
https://doi.org/10.1093/carcin/14.6.1189
https://doi.org/10.1093/carcin/14.6.1189
Autor:
Robert M. Kovatch, William Lijinsky
Publikováno v:
Toxicology and Industrial Health. 8:267-271
The industrial chemical glycidol is a directly acting mutagen and a broadly acting carcinogen in rats. It was administered to Syrian golden hamsters (20 male and 20 female) by gavage of 12 mg twice a week for 60 weeks. The total dose per animal was 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d228e3c75f33afaff9215af020f7f08b
https://doi.org/10.1177/074823379200800504
https://doi.org/10.1177/074823379200800504
Publikováno v:
Cancer Letters. 63:101-107
Two N-nitroso compounds that are derivatives of N,N-dimethylethylenediamine and are therefore strongly basic, were tested for carcinogenic activity. They were methylnitrosamino-N,N-dimethylethylamine (MNDMEA) and N,N-dimethylaminoethylnitrosoethylure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3558fb4f1bcf444fe34d207bc49c8c0
https://doi.org/10.1016/0304-3835(92)90059-5
https://doi.org/10.1016/0304-3835(92)90059-5
Publikováno v:
Cancer Letters. 61:1-5
To compare the susceptibilities of the skin of different strains of mice to the carcinogenic effect of a directly acting alkylating agent, groups of 20 mice were treated twice a week with 25 μl of a solution of methylnitrosourea in methanol. The sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5efd0d5562d6313bce3955957a1586
https://doi.org/10.1016/0304-3835(91)90069-t
https://doi.org/10.1016/0304-3835(91)90069-t
Publikováno v:
Japanese Journal of Cancer Research : Gann
Several nitrosamines and an azoxyalkane have been administered intravesically to groups of 12 female F344 rats, twice a week for 20 or 30 weeks. Many of the nitrosamines were as efficacious in giving rise to the same tumors of internal organs as when
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e16cc7677d201dacde24aba9bf2888
http://europepmc.org/articles/PMC5918600
http://europepmc.org/articles/PMC5918600