Zobrazeno 1 - 8
of 8
pro vyhledávání: '"William Leonard Wishart"'
Autor:
J. Fraser Glickman, Gabriele Hofmann, Marjo Götte, Anne-Isabelle Michou-Gallani, William Leonard Wishart, Daniela Gabriel
Publikováno v:
Journal of Neuroscience Methods. 192:7-16
The development of high-content screening technologies including automated immunostaining, automated image acquisition and automated image analysis have enabled higher throughput of cellular imaging-based assays. Here we used high-content imaging to
Autor:
Pierre Martin, Dieter Huesken, Jonathan Hall, Gabriele Dorn, Francois Natt, Jan Weiler, Joerg Lange, William Leonard Wishart
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 22:641-644
Functional genomics is inundating the pharmaceutical industry with large numbers of potential gene targets from several sources such as gene expression profiling experiments (DNA microchips, proteomics) or database mining. Oligonucleotide-based RNA-k
Autor:
Gabriele Dorn, Glen Wotherspoon, Jonathan Hall, Stuart Bevan, Sadhana Patel, Samir Abdel'Al, Pam Ganju, Francois Natt, Janet Winter, Alyson Fox, L. H. Eunson, William Leonard Wishart, Sarah Moffatt, Jane Barclay
Publikováno v:
The Journal of Neuroscience. 22:8139-8147
The excitation of nociceptive sensory neurons by ATP released in injured tissue is believed to be mediated partly by P2X(3)receptors. Although an analysis of P2X(3) knock-out mice has revealed some deficits in nociceptive signaling, detailed analysis
Autor:
Marta Cortes-Cros, Danilo Guerini, Luis M. Craveiro, Maribel Osinde, William Leonard Wishart, Klaus Seuwen, Rajeev Sivasankaran, Martin E. Schwab, Youngah Shin, Florian Mullershausen, Michaela Thallmair, Kumlesh K. Dev, Frederic Bassilana
Publikováno v:
Journal of neurochemistry. 102(4)
Sphingosine-1-phosphate (S1P) receptors are widely expressed in the central nervous system where they are thought to regulate glia cell function. The phosphorylated version of fingolimod/FTY720 (FTY720P) is active on a broad spectrum of S1P receptors
Autor:
Maja Hemmings-Mieszczak, Gabriele Dorn, William Leonard Wishart, Francois Natt, Jonathan Hall
Synthetic 21-bp-long short interfering RNAs (siRNA) can stimulate sequence-specific mRNA degradation in mammalian cell cultures, a process referred to as RNA interference (RNAi). In the present study, the potential of RNAi was compared to the traditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e402c6eb985f5237a1c9dfaea5d02cc0
https://europepmc.org/articles/PMC153750/
https://europepmc.org/articles/PMC153750/
Autor:
Gabriele Dorn, Samir Abdel'Al, Ingeborg Meigel, Francois Natt, Johannes Mosbacher, Jonathan Hall, William Leonard Wishart, Jan Weiler
Publikováno v:
Antisensenucleic acid drug development. 11(3)
P2X3 is one receptor of a family of seven ligand-gated ion channels responding to purines. Increasing evidence indicates its involvement in neuronal signaling and in pain. However, there is currently no selective inhibitor known for this subtype. In
Autor:
Michael Beverly, Armin Beyerbach, Karine Litherland, David Morrissey, Julien A. Boos, Mari-Luz Piccolotto, Piet Swart, Juerg Hunziker, Andre Dattler, Werner Zuercher, Thomas Faller, Sandro Gfeller, David W. Kirk, Iwan Beuvink, Fabian Von Arx, Esther van de Kerkhof, Jesper Christensen, Philippe Neuner, William Leonard Wishart
Publikováno v:
Nucleic Acids Research
Efficient tissue-specific delivery is a crucial factor in the successful development of therapeutic oligonucleotides. Screening for novel delivery methods with unique tissue-homing properties requires a rapid, sensitive, flexible and unbiased techniq
Autor:
Jane Barclay, Maja Hemmings-Mieszczak, Alyson Fox, Stuart Bevan, Pam Ganju, Gabriele Dorn, William Leonard Wishart, Pierre Martin, Jonathan Hall, Sadhana Patel, Glen Wotherspoon, Francois Natt
Publikováno v:
King's College London
Nucleic Acids Research, 32 (5)
Nucleic Acids Research, 32 (5)
Double stranded, short interfering RNAs (siRNA) of 21–22 nt length initiate a sequence-specific, post-trancriptional gene silencing in animals and plants known as RNA interference (RNAi). Here we show that RNAi can block a pathophysiological pain r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2110f6702fa3a60a1bdb2d2e704e2f
https://kclpure.kcl.ac.uk/portal/en/publications/sirna-relieves-chronic-neuropathic-pain(7cd69fba-9922-4a6b-8150-9ce14f3ba4a5).html
https://kclpure.kcl.ac.uk/portal/en/publications/sirna-relieves-chronic-neuropathic-pain(7cd69fba-9922-4a6b-8150-9ce14f3ba4a5).html