Výsledky vyhledávání - "William L. Zeile"

Maternal phenylketonuria syndrome: studies in mice suggest a potential approach to a continuing problem

Autor: William L. Zeile, Roberto T. Zori, Charles A. O'Neill, Philip J. Laipis, Laurie S. Tsuruda, Brian J. O'Donnell, Donald G. Musson, Helen McCune

Publikováno v: Pediatric Research

Background Untreated phenylketonuria (PKU), one of the most common human genetic disorders, usually results in mental retardation. Although a protein-restricted artificial diet can prevent retardation, dietary compliance in adults is often poor. In p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43987121373a8f6bbbe21765c744d73f
https://pubmed.ncbi.nlm.nih.gov/29278642

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Partial rescue of neuropathology in the murine model of PKU following administration of recombinant phenylalanine ammonia lyase (pegvaliase)

Autor: Marc H. Goldfinger, William L. Zeile, Laurie S. Tsuruda, Jonathan D. Cooper, Carley R. Corado, Charles A. O'Neill, Philip J. Laipis

Publikováno v: Goldfinger, M, Zeile, W L, Corado, C R, O'Neill, C A, Tsuruda, L S, Laipis, P J & Cooper, J D 2017, ' Partial rescue of neuropathology in the murine model of PKU following administration of recombinant phenylalanine ammonia lyase (pegvaliase) ', MOLECULAR GENETICS AND METABOLISM . https://doi.org/10.1016/j.ymgme.2017.04.013

Pegylated recombinant phenylalanine ammonia lyase (pegvaliase) is an enzyme substitution therapy being evaluated for the treatment of phenylketonuria (PKU). PKU is characterized by elevated plasma phenylalanine, which is thought to lead to a deficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1884664ea52fdf1e2f5b6e0d1631d102
https://pubmed.ncbi.nlm.nih.gov/28506393

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Listeria's right-handed helical rocket-tail trajectories: Mechanistic implications for force generation in actin-based motility

Autor: Fangliang Zhang, William L. Zeile, Richard B. Dickinson, Daniel L. Purich

Publikováno v: Cell Motility and the Cytoskeleton. 60:121-128

Listeria monocytogenes forms right-handed helical rocket tail trajectories during actin-based motility in cell-free extracts, and this stereochemical feature is consistent with actoclampin's affinity-modulated, clamped-filament elongation model [Dick

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05186b644d4bd2a0e216934a05748f46
https://doi.org/10.1002/cm.20050

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Actin-based endosome and phagosome rocketing in macrophages: activation by the secretagogue antagonists lanthanum and zinc

Autor: William L. Zeile, Frederick S. Southwick, Daniel L. Purich, Fangliang Zhang, Wei Li

Publikováno v: Cell Motility and the Cytoskeleton. 54:41-55

Although motile endocytic vesicles form actin-rich rocket tails [Merrifield et al., 1999: Nature Cell Biol 1:72-74], the mechanism of intracellular organelle locomotion remains poorly understood. We now demonstrate that bone marrow macrophages treate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b15cef64e3254fc8cd71f95c2e073c6
https://doi.org/10.1002/cm.10083

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Guidance of actin filament elongation on filament-binding tracks

Autor: Daniel L. Purich, Gary E. McGuire, Richard B. Dickinson, Kimberly A. Interliggi, William L. Zeile, Suzanne A. Ciftan-Hens

Publikováno v: Langmuir : the ACS journal of surfaces and colloids. 23(23)

Biomolecular motors, which convert chemical energy into mechanical work in intracellular processes, have high potential in bionanotechnology in vitro as molecular shuttles or nanoscale actuators. In this context, guided elongation of actin filaments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914b31df6a2c36e755349cec2ab6ae57
https://pubmed.ncbi.nlm.nih.gov/17929952

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Vaccinia locomotion in host cells: Evidence for the universal involvement of actin-based motility sequences ABM-1 and ABM-2

Autor: Jackie I. Lewis, Richard C. Condit, Daniel L. Purich, Frederick S. Southwick, William L. Zeile

Vaccinia uses actin-based motility for virion movement in host cells, but the specific protein components have yet to be defined. A cardinal feature of Listeria and Shigella actin-based motility is the involvement of vasodilator-stimulated phosphopro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4cb5bc6b1f6e1b2723bf67f0d102a6a
https://europepmc.org/articles/PMC24964/

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Recognition of two classes of oligoproline sequences in profilin-mediated acceleration of actin-based Shigella motility

Autor: William L. Zeile, Frederick S. Southwick, Daniel L. Purich

Publikováno v: The Journal of Cell Biology

The gram negative rod Shigella flexneri uses it surface protein IcsA to induce host cell actin assembly and to achieve intracellular motility. Yet, the IcsA protein lacks the oligoproline sequences found in ActA, the surface protein required for loco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebcbef3c325b961f35cd6fecf0d9966
https://pubmed.ncbi.nlm.nih.gov/8601612

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Akademický článek

Guidance of Actin Filament Elongation on Filament-Binding Tracks.

Autor: Kimberly A. Interliggi, William L. Zeile, Suzanne A. Ciftan-Hens, Gary E. McGuire, Daniel L. Purich, Richard B. Dickinson

Publikováno v: Langmuir; Nov2007, Vol. 23 Issue 23, p11911-11916, 6p

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Akademický článek

Listeria's right-handed helical rocket-tail trajectories: Mechanistic implications for force generation in actin-based motility.

Autor: William L. Zeile, Fangliang Zhang, Richard B. Dickinson, Daniel L. Purich

Publikováno v: Cell Motility & the Cytoskeleton; Feb2005, Vol. 60 Issue 2, p121-128, 8p

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