Zobrazeno 1 - 6
of 6
pro vyhledávání: '"William L. Watts"'
Publikováno v:
Chirality. 34:1078-1093
While not initially a focus or priority, in recent decades, an emphasis has been placed on the activity of individual enantiomers of widely used pesticides. Of particular note are organophosphorus-based pesticides like fenamiphos and profenofos, as e
Autor:
Tony Q. Yan, William L. Watts, Frank Riley, James Lee, Jeannie T. Lee, Yun Huang, Jim Bradow, Mark Hardink, Joseph Barendt, Pilar Franco
Publikováno v:
Journal of Chromatography A. 1374:238-246
Polysaccharide-derived selectors are often used in the separation of enantiomers by supercritical fluid chromatography (SFC). Their recognition patterns are normally investigated with alcohols and acetonitrile as modifiers. The present paper describe
Autor:
Li Di, Leonard A. McDonald, Mairead Young, Lisa Nogle, Dahui Zhou, Brian L. Marquez, Mei-Yi Zhang, William L. Watts, Frank E. Koehn, Alvin C. Bach, Yanxuan Cai, Alan G. Sutherland, Neal Byrne, Guy T. Carter, Michael Z. Kagan, Edward H. Kerns, Mark Tischler, Carl J. Balibar, Oliver J. McConnell, Igor Goljer, Gerhard Schlingmann, Yanan He, Don Herold, Douglas M. Ho, Michael Chlenov, Christopher J. Petucci, R. Thomas Williamson, Gregory J. Tawa, Yingru Zhang, Vasilios Marathias, Christina M. Kraml, Kristi Fan
Publikováno v:
Chirality. 19:658-682
The application of Chiral Technology, or the (extensive) use of techniques or tools for the determination of absolute stereochemistry and the enantiomeric or chiral separation of racemic small molecule potential lead compounds, has been critical to s
Autor:
Paige E. Mahaney, Puwen Zhang, Casey C. McComas, Eugene John Trybulski, Ani Sarkahian, Nicole R. Sullivan, Liza Leventhal, Albert J. Uveges, Lisa Nogle, William L. Watts, An T. Vu
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:8455-8466
Compounds with a combination of norepinephrine and serotonin reuptake inhibition have been approved in the US and Europe for a number of indications, including major depressive disorder and pain disorders such as diabetic neuropathy and fibromyalgia.
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 40:901-909
A direct preparative purification of all four isomers of the unnatural amino acid β-methylphenylalanine was achieved using supercritical fluid chromatography (SFC) with stacked-injection. Final purification of the Cbz-methyl ester derived isomers wa
Publikováno v:
Journal of Chromatography A. 1049:75-84
A novel strategy for rapid chiral method development has been developed using multi-column parallel screening and circular dichroism (CD) signal pooling. Described is the first use of a customized HPLC system that integrates an HPLC auto-sampler, one