STAT-6 mediates TRAIL induced RANK ligand expression in stromal/preosteoblast cells

Autor: Yuvaraj Sambandam, Sundaravadivel Balasubramanian, Kumaran Sundaram, Sakamuri V. Reddy, Balakrishnan Pillai, William L. Ries, Christina Voelkel-Johnson

Publikováno v: Bone. 71:137-144

Receptor activator of nuclear factor kappa-B ligand (RANKL) is a critical osteoclastogenic factor expressed in bone marrow stromal/osteoblast lineage cells. Tumor necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL) levels are elevated in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb94a29bdc6cbd63b981c12e0e953ad
https://doi.org/10.1016/j.bone.2014.10.016

Factors that affect postnatal bone growth retardation in the twitcher murine model of Krabbe disease

Autor: Srinivasan Shanmugarajan, Gonzalo Arboleda, Inderjit Singh, William L. Ries, Miguel A. Contreras, Avtar K. Singh

Publikováno v: Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2010, 1802 (7-8), pp.601. ⟨10.1016/j.bbadis.2010.04.006⟩

Krabbe disease is an inherited lysosomal disorder in which galactosylsphingosine (psychosine) accumulates mainly in the central nervous system. To gain insight into the possible mechanism(s) that may be participating in the inhibition of the postnata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccc85d3f106de09287e0f661c0b0cc5

Osteoclast inhibitory peptide‐1 (OIP‐1) inhibits measles virus nucleocapsid protein stimulated osteoclast formation/activity

Autor: Parmita Pati, Srinivasan Shanmugarajan, D. Sudhaker Rao, William L. Ries, Sakamuri V. Reddy, Rimon F. Youssef

Publikováno v: Journal of Cellular Biochemistry. 104:1500-1508

Paget's disease (PD) of bone is characterized by increased activity of large abnormal osteoclasts (OCLs) which contain paramyxoviral nuclear and cytoplasmic inclusions. MVNP gene expression has been shown to induce pagetic phenotype in OCLs. We previ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e32e71f3fa520dd71d9dc09509d50b9
https://doi.org/10.1002/jcb.21723

RANK ligand expression in heat shock factor-2 deficient mouse bone marrow stromal/preosteoblast cells

Autor: Masahiro Ito, Ivor J. Benjamin, Hiroshi Kajiya, William L. Ries, Hayato Ohshima, Sakamuri V. Reddy, Shin Ichi Kenmotsu

Publikováno v: Journal of Cellular Biochemistry. 97:1362-1369

Heat Shock Proteins (HSP) are molecular chaperones activated upon cellular stress/stimuli. HSP gene expression is regulated by Heat Shock Factors (HSF). We have recently demonstrated a functional role for heat shock factor-2 (HSF-2) in fibroblast gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597f9739e00e02f25b080b21ee749d41
https://doi.org/10.1002/jcb.20737

IFN-γ Enhances Osteoclast Generation in Cultures of Peripheral Blood from Osteopetrotic Patients and Normalizes Superoxide Production

Autor: Prema R. Madyastha, William L. Ries, Su Yang, L. Lyndon Key

Publikováno v: Journal of Interferon & Cytokine Research. 20:645-652

Interferon-gamma (IFN-gamma) treatment increases osteoclastic bone resorption in vivo in patients with malignant osteopetrosis (OP). The treatment effect was studied in vitro in osteoclasts generated by culturing peripheral white blood cells (PWBC) f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be93b48f9aa763653e703a201efff6f8
https://doi.org/10.1089/107999000414826