Výsledky vyhledávání - "William L. Neumann"

Akademický článek

Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents

Autor: Timothy M. Doyle, Mark R. Hutchinson, Kathryn Braden, Kali Janes, Vicky Staikopoulos, Zhoumou Chen, William L. Neumann, Sarah Spiegel, Daniela Salvemini

Publikováno v: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-8 (2020)

Abstract Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 r

Externí odkaz: https://doaj.org/article/aa30603a92e14637a5ad0de991f3f7b6

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Akademický článek

2-Chlorofatty acids induce Weibel-Palade body mobilization[S]

Autor: Celine L. Hartman, Mark A. Duerr, Carolyn J. Albert, William L. Neumann, Jane McHowat, David A. Ford

Publikováno v: Journal of Lipid Research, Vol 59, Iss 1, Pp 113-122 (2018)

Endothelial dysfunction is a hallmark of multiple inflammatory diseases. Leukocyte interactions with the endothelium have significant effects on vascular wall biology and pathophysiology. Myeloperoxidase (MPO)-derived oxidant products released from l

Externí odkaz: https://doaj.org/article/e65af01ee7db40ca9ae78ebbd606e3b2

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Akademický článek

Targeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicity

Autor: Samson Jamesdaniel, Rajamani Rathinam, William L. Neumann

Publikováno v: Redox Biology, Vol 10, Iss C, Pp 257-265 (2016)

Cisplatin-induced ototoxicity remains a primary dose-limiting adverse effect of this highly effective anticancer drug. The clinical utility of cisplatin could be enhanced if the signaling pathways that regulate the toxic side-effects are delineated.

Externí odkaz: https://doaj.org/article/2798e4ddd679459e953ec0b91e10995f

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Akademický článek

Chlorinated lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal

Autor: Dhanalakshmi S. Anbukumar, Laurie P. Shornick, Carolyn J. Albert, Melissa M. Steward, Raphael A. Zoeller, William L. Neumann, David A. Ford

Publikováno v: Journal of Lipid Research, Vol 51, Iss 5, Pp 1085-1092 (2010)

Neutrophils are important in the host response against invading pathogens. One chemical defense mechanism employed by neutrophils involves the production of myeloperoxidase (MPO)-derived HOCl. 2-Chlorohexadecanal (2-ClHDA) is a naturally occurring li

Externí odkaz: https://doaj.org/article/1a255333c0304906b69adedcb9e82b5d

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