Zobrazeno 1 - 10
of 37
pro vyhledávání: '"William L. McPheat"'
Autor:
Vijay Gottipati, Anna Marley, William L. McPheat, Bronson A. Haynes, Lindsey Glenn, Jerry L. Nadler, Göran I. Hansson, Ryan W. Huyck, Anca D. Dobrian
Publikováno v:
Prostaglandins & Other Lipid Mediators. 136:23-32
The 12-lipoxygenase (12LO) pathway is a promising target to reduce islet dysfunction, adipose tissue (AT) inflammation and insulin resistance. Optimal pre-clinical models for the investigation of selective12LO inhibitors in this context have not yet
Autor:
Alexander K. Smárason, David Griffiths, Catrin E. Moore, William L. McPheat, Shelley Segal, Derrick W. Crook, Nicholas P. J. Day, Adrian V. S. Hill, Kyle Knox, S. Roy, Kenneth I. Welsh
Summary Background Streptococcus pneumonias is a major cause of morbidity and mortality in developed and developing countries. No common genetic determinants of susceptibility have been defined. Mannose-binding lectin (MBL) is a key mediator of innat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31dbb18283dc8611517aa01adcd4ec6
https://doi.org/10.1016/s0140-6736(02)08516-1
https://doi.org/10.1016/s0140-6736(02)08516-1
Autor:
William L. McPheat, Clinton S. Robbins, Jiadai Zou, Ralf Gilsbach, Peter Stachon, Natalie Hoppe, Sonja Hergeth, Timo Heidt, Peter Libby, Florian Willecke, Jan Kornemann, Kelly Daryll Blanz, Andreas Zirlik, Lutz Hein, Shaun Hawley, Filip K. Swirski, Bianca Dufner, Carmen Härdtner, Constantin von zur Mühlen, Dennis Wolf, Louisa M.S. Gerhardt, Nathaly Anto-Michel, Ingo Hilgendorf, Christoph Bode, A Lindau, Martin Braddock, Serjosha Geis
Publikováno v:
Basic Research in Cardiology
Macrophages in the arterial intima sustain chronic inflammation during atherogenesis. Under hypercholesterolemic conditions murine Ly6Chigh monocytes surge in the blood and spleen, infiltrate nascent atherosclerotic plaques, and differentiate into ma
Publikováno v:
Expert Opinion on Investigational Drugs. 16:1879-1893
The 5-lipoxygenase pathway is responsible for the production of leukotrienes--inflammatory lipid mediators that have a role in innate immunity, but that can also have pathological effects in inflammatory diseases. Recently, a potential link between l
Autor:
Stefan Pierrou, Wisam Khider, Birgitta M. Gleeson, Erika Cavallin, Kenneth Martin, Arun H.S. Kumar, Mohammed T. Ali, Carl J. Vaughan, Noel M. Caplice, Elizebeth C. Turner, William L. McPheat, Chien-Ling Huang
Publikováno v:
Biomaterials. 69
We evaluated the therapeutic efficacy of a novel drug eluting stent (DES) inhibiting inflammation and smooth muscle cell (SMC) proliferation. We identified CX3CR1 as a targetable receptor for prevention of monocyte adhesion and inflammation and in-st
Autor:
Ellen Knutsen Rydberg, Alexandra Krettek, Ann-Cathrine Jönsson-Rylander, Bertil G. Ohlsson, William L. McPheat, Karin Ekström, Per-Arne Svensson, Christina Ullström, Göran I. Hansson, Lena M. S. Carlsson, Olov Wiklund, Lillemor Mattsson Hultén
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 24:2040-2045
Objective— Macrophage-mediated oxidation of low-density lipoprotein (LDL) by enzymes, such as the lipoxygenases, is considered of major importance for the formation of oxidized LDL during atherogenesis. Macrophages have been identified in hypoxic a
Autor:
Kittipan Rerkasem, Baiping Zhang, Philip C. Calder, Per Eriksson, Clifford P. Shearman, Shu Ye, Angharad R. Morgan, Patrick J. Gallagher, William L. McPheat, G.E. Morris, Robert F. Grimble
Publikováno v:
Stroke. 35:1310-1315
Background and Purpose— Previous studies have shown that atherosclerotic lesions express a number of matrix metalloproteinases (MMPs). Here we investigated whether transcript levels of MMP-1, -3, -7, -9, and -12 in carotid atherosclerotic plaques w
Autor:
Adriano Henney, Claire A. Minshull, Derek Barratt, Siân Rowsell, David Waterson, Richard A. Pauptit, Holly Jepson, Paul Hawtin, Anthony M. Slater, William L. McPheat, S.M. Brockbank
Publikováno v:
Journal of Molecular Biology. 319:173-181
Matrix metalloproteinases (MMPs) and their inhibitors are important in connective tissue re-modelling in diseases of the cardiovascular system, such as atherosclerosis. Various members of the MMP family have been shown to be expressed in atherosclero
Autor:
William L. McPheat, Anne Teresa J. Vie, L. Patricia Londono, Xiao M. Gao, Huw B. Jones, Gordon Dougan, George Booth
Publikováno v:
FEMS Immunology & Medical Microbiology. 27:117-125
Mice harbouring a null deletion mutation in the IFNgamma receptor gene were used to study the role of IFNgamma responsiveness during experimental systemic candidiasis of mucosal or haematogenous origin. After intravenous (i.v.) or intranasal (i.n.) c
Publikováno v:
DNA Sequence. 11:315-319
We have identified an Aspergillus nidulans gene encoding a RecQ family helicase which we have therefore named recQ. The A. nidulans recQ protein is most closely related in sequence to human recQ helicase 5. Like the latter polypeptide, A. nidulans re