Výsledky vyhledávání - "William L. Garbrecht"

(8.beta.)-6-Methylergoline amide derivatives as serotonin antagonists: N1-substituent effects on vascular 5HT2 receptor activity

Autor: Marlene L. Cohen, Kathleen R. Whitten, Jerry W. Misner, Marzoni Gifford P, William L. Garbrecht

Publikováno v: Journal of Medicinal Chemistry. 33:652-656

A series of (8 beta)-6-methylergoline amide derivatives was synthesized with various alkyl substituents in the N1-position in order to evaluate their effectiveness in blocking vascular 5HT2 receptors. The influence of both the N1 substituent and amid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124f46d93da8a39c6b9823d48fd344c2
https://doi.org/10.1021/jm00164a029

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6-Methylergoline-8-carboxylic acid esters as serotonin antagonists: N1-substituent effects on 5HT2 receptor affinity

Autor: William L. Garbrecht, Pawel Fludzinski, Gifford P. Marzoni, Marlene L. Cohen

Publikováno v: Journal of Medicinal Chemistry. 30:1823-1826

Three series of 6-methylergoline-8-carboxylic acid esters with various alkyl substituents in the N1-position were prepared and their 5HT2 receptor affinities measured. Some overlap occurred in the 5HT2 receptor affinities of the different ester serie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f4c0de82a5b18aa121fb50b15829ea
https://doi.org/10.1021/jm00393a024

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[14C] - radiolabeling of {[trans-(8β)]-6-methyl-1-(1-methylethyl) ergoline-8-carboxylic acid, 4-methoxycyclohexyl ester (Z)-2-butenedioate [(1:1)]. A potent and selective 5ht2-receptor antagonist

Autor: William J. Wheeler, Gifford P. Marzoni, William L. Garbrecht

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 25:429-438

[14C]-Labeled {[trans-(8 β)]-6-methyl-1-(1-methylethyl)ergoline-8-carboxylic acid, 4-methoxycyclohexyl ester (Z)-2-butenedioate (1:1)} (LY281067) (10) was synthesized from unlabeled 6-methyl-1-(1-methylethyl)ergoline-8-carboxylic acid (2). The [14C]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97460db6cc07d4eb9e4143d21d77b0c9
https://doi.org/10.1002/jlcr.2580250409

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N 1-Alkylation of Dihydrolysergic Acid

Autor: Gifford Marzoni, William L. Garbrecht

Publikováno v: Synthesis. 1987:651-653

The present invention provides a process for N-alkylating dihydrolysergic acid with a substituted benzenesulfonate derivative.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b0d758b6e52f8ba6fb2a60c9b3ad9a6
https://doi.org/10.1055/s-1987-28037

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