Výsledky vyhledávání - "William L. Fitch"

Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy

Autor: Robert K. Leśniak, R. Jeremy Nichols, Marcus Schonemann, Jing Zhao, Chandresh R. Gajera, William L. Fitch, Grace Lam, Khanh C. Nguyen, Mark Smith, Thomas J. Montine

Publikováno v: European journal of medicinal chemistry. 229

Mutations in the Leucine Rich Repeat Protein Kinase 2 gene (LRRK2) are the most common genetic causes of Parkinson's Disease (PD). The G2019S mutation is the most common inherited LRRK2 mutation, occurs in the kinase domain, and results in increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643144c274ffd8f416b88301b9674c66
https://pubmed.ncbi.nlm.nih.gov/34992038

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Tunable Enzymatic Synthesis of the Immunomodulator Lipid IVA To Enable Structure–Activity Analysis

Autor: Chaitan Khosla, William L Fitch, Camilla M. Kao, Curt R. Fischer, Brad A. Palanski, Abrahim El Gamal, Karthik Sankaranarayanan, Xirui X Antaris

Publikováno v: Journal of the American Chemical Society. 141:9474-9478

The Lipid A family of glycolipids, found in the outer membranes of all Gram-negative bacteria, exhibits considerable structural diversity in both lipid and glycan moieties. The lack of facile methods to prepare analogues of these natural products rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::327a7a09334a6a64d764c2ac0e414c79
https://doi.org/10.1021/jacs.9b03066

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Using LC Retention Times in Organic Structure Determination: Drug Metabolite Identification

Autor: Cyrus Khojasteh, William L. Fitch, Ignacio Aliagas, Kevin M. Johnson

Publikováno v: Drug Metabolism Letters

Background: There is a continued need for improvements in the efficiency of metabolite structure elucidation. Objective: We propose to take LC Retention Time (RT) into consideration during the process of structure determination. Methods: Herein, we d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfcc42959da9123b16c70ea611efc7a4
https://doi.org/10.2174/1872312812666180802093347

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In vitro and in vivo metabolite identification of a novel benzimidazole compound ZLN005 by liquid chromatography/tandem mass spectrometry

Autor: William L. Fitch, Hongxiang Tang, Edgar G. Engleman, Khoa Dinh Nguyen, Samuel D. Banister, Xiaolan Zhang, Lewis Yu, Wenchao Sun, Jayakumar Rajadas

Publikováno v: Rapid Communications in Mass Spectrometry. 32:480-488

Rationale A novel benzimidazole compound ZLN005 was previously identified as a transcriptional activator of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) in certain metabolic tissues. Upregulation of PGC-1α by ZLN005 has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3026acc6997e63667273f95819870978
https://doi.org/10.1002/rcm.8060

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Tunable Enzymatic Synthesis of the Immunomodulator Lipid IV

Autor: Karthik, Sankaranarayanan, Xirui X, Antaris, Brad A, Palanski, Abrahim, El Gamal, Camilla M, Kao, William L, Fitch, Curt R, Fischer, Chaitan, Khosla

Publikováno v: J Am Chem Soc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e24a9828f061d157726c72d463f8136d
https://pubmed.ncbi.nlm.nih.gov/31184877

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RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials

Publikováno v: Expert opinion on investigational drugs, vol 26, iss 1
Oronsky, B; Paulmurugan, R; Foygel, K; Scicinski, J; Knox, SJ; Peehl, D; et al.(2017). RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials. Expert Opinion on Investigational Drugs, 26(1), 109-119. doi: 10.1080/13543784.2017.1268600. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/9c1501w2

© 2016 Informa UK Limited, trading as Taylor & Francis Group. Introduction: According to Hanahan and Weinberg, cancer manifests as six essential physiologic hallmarks: (1) self-sufficiency in growth signals, (2) insensitivity to growth-inhibitory si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca7b04d469bcced5e4d092f188c206b
https://escholarship.org/uc/item/9c1501w2

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Development of methods for the bioanalysis of RRx-001 and metabolites

Autor: Vance Cooper, Jan Scicinski, Rebecca Cosford, Bryan Oronsky, Thomas Fleischmann, William L. Fitch, Rebecca Hadar, Michael D. Taylor, Michael S. Alexander

Publikováno v: Bioanalysis. 6:947-956

Background: Bioanalytical methods were required to study the novel anticancer drug, RRx-001 preclinically and for clinical pharmacokinetic analysis; however, RRx-001 quickly and completely disappeared on intravenous administration in preclinical spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89bd97600ff7ef81599b481100d717f0
https://doi.org/10.4155/bio.13.331

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Identification of drug targets by chemogenomic and metabolomic profiling in yeast

Autor: Gary Peltz, David L. Dill, Sofia Aronova, Ming Zheng, Robert P. St.Onge, Ulrich Schlecht, Stephan Baumann, William L. Fitch, Ronald W. Davis, Manhong Wu, Sundari Suresh, Weiruo Zhang

Publikováno v: Pharmacogenetics and Genomics. 22:877-886

Objective To advance our understanding of diseasebiology, the characterization of the molecular targetfor clinically proven or new drugs is very important.Because of its simplicity and the availability of strainswith individual deletions in all of it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0626ae415ba2db5ec6eaa6dfe07293c4
https://doi.org/10.1097/fpc.0b013e32835aa888

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